Dr Gavin Pinniger
Anatomy, Physiology and Human Biology, School of
- Contact details
- School of Anatomy, Physiology and Human Biology
The University of Western Australia (M311)
35 Stirling Highway
CRAWLEY WA 6009
- +61 8 6488 3380
- +61 8 6488 1025
- Room 1.06A, Physiology Building, Perth campus
- BSc PhD W'gong
- Dr Gavin Pinniger completed his undergraduate and PhD studies in the Department of Biomedical Science at the University of Wollongong in New South Wales. He then received a Travelling Research Fellowship from The Wellcome Trust to conduct his post-doctoral research at the University of Bristol in the United Kingdom before coming to UWA.
- Key research
- Dr Pinniger’s research focuses on the physiological investigation of skeletal muscle function in health and disease. He is particularly interested in the molecular mechanisms underlying muscle contraction and the evaluation of medical treatments for muscular weakness and diseases such as Duchenne muscular dystrophy. Dr Pinniger's recent research has focused on the effects of common, clinically relevant antenatal exposures on preterm diaphragm function.
- 1.Song, Y., Demmer, D.L., Pinniger, G.J., Lavin, T., MacMillan, M.V., Pillow, J.J., & Bakker, A.J. Effect of maternal steroid on developing diaphragm integrity. PLOS ONE. March 28, 2014. DOI: 10.1371/journal.pone.0093224
2. Sitparan, P.K., Pagel, C.N., Pinniger, G.J., Yoo, H.J., Mackie, E.J. & Bakker, A.J. The contractile properties of slow and fast skeletal muscles from protease activated receptor-1 null mice. Muscle & Nerve. 2014. DOI: 10.1002/mus.24256.
3.Song, Y., Pinniger, G.J., Bakker, A.J., Moss T.J.M., Noble, P.B., Berry & Pillow, J.J. (2013). Lipopolysaccharide-induced weakness in the preterm diaphragm is associated with mitochondrial electron transport chain dysfunction and oxidative stress. PLoS ONE 8(9): e73457. doi:10.1371/journal.pone.0073457.
4.Song, Y., Karisnan, K., Noble, P.B., Berry, C.A., Lavin, T., Moss T.J.M., Bakker, A.J., Pinniger, G.J.* & Pillow, J.J.* (2013). In utero lipopolysaccharide exposure impairs preterm diaphragm contractility. American Journal of Respiratory Cell and Molecular Biology, (in press). * joint senior authors.
5.Lavin, T., Song, Y., Bakker, A.J., McLean, C.J., Macdonald, W.A., Noble, P.B., Berry, C.A., Pillow, J.J. & Pinniger, G.J. (2013). Developmental changes in diaphragm muscle function in the preterm and postnatal lamb. Pediatric Pulmonology, 48(7):640-648.
6.Pinniger, G.J., Lavin, T. & Bakker, A.J. (2012). Skeletal muscle weakness caused by carrageenan-induced inflammation. Muscle & Nerve, 46:413-420.
7.Rubenson, J., Pires, N.J., Loi, H.O., Pinniger, G.J. & Shannon, D. (2012). On the ascent: the soleus operating length is conserved to the ascending limb of the force-length curve across gait mechanics in humans. Journal of Experimental Biology, 215, 3539-3551.
8.Roots, H., Pinniger, G.J., Offer, G.W. & Ranatunga, K.W. (2012). Mechanism of force enhancement during and after lengthening of active muscle; a temperature dependence study. Journal of Muscle Research and Cell Motility, 33(5):313-325.
9.Piers, A.T., Lavin, T., Radley-Crabb, H.G., Bakker, A.J., Grounds, M.D. & Pinniger, G.J. (2011). Blockade of TNF in vivo using cV1q antibody reduces contractile dysfunction of skeletal muscle in response to eccentric exercise in dystrophic mdx and normal mice. Neuromuscular Disorders, 21:132-141.
10.Ranatunga, K.W., Roots, H., Pinniger, G.J., & Offer, G.W. (2010). Crossbridge and non-crossbridge contributions to force in shortening and lengthening muscle. Advances in Experimental Medicine and Biology, 1, Volume 682, Muscle Biophysics, Pages 207-221. ed Rassier, D.E., Springer, New York.
11.Ramsey, K.A., Bakker, A.J., & Pinniger, G.J. (2010). Fibre-type dependence of stretch-induced force enhancement in mammalian skeletal muscle. Muscle & Nerve, 42:769-777.
12.Palmisano, S., Pinniger, G.J., Ash, A., & Steele, J.R. (2009). Effects of simulated viewpoint jitter on visually induced postural sway. Perception, 38:442-453.
13.Ridgley, J.A., Pinniger, G.J., Hamer, P.W. & Grounds, M.D. (2009). The physiological effects of IGF-1 (class 1:Ea transgene) over-expression on exercise-induced muscle damage and adaptation in dystrophic muscles of mdx mice. Pflugers Archive – European Journal of Physiology, 457:1121–1132.
14.*Ranatunga, K.W., Coupland, M.E., Pinniger, G.J., Roots, H. & Offer, G.W. (2007). Force generation examined by laser temperature-jumps in shortening and lengthening mammalian (rabbit psoas) muscle fibres. Journal of Physiology, 585(1):263-277.
15.Pinniger, G.J. & Cresswell, A.G. (2007). Residual force enhancement after lengthening is present during submaximal plantar flexion and dorsiflexion actions in humans. Journal of Applied Physiology, 102(1):18-25.
16.Pinniger, G.J., Ranatunga, K.W. & Offer, G.W. (2006). Crossbridge and non-crossbridge contributions to tension in lengthening muscle: force-induced reversal of the power stroke. Journal of Physiology, 573(3):627-643.
17.Bruton, J.D., Pinniger, G.J., Lännergren, J. & Westerblad, H. (2006). The effects of the myosin-II inhibitor N-benzyl-p-toluene sulphonamide (BTS) on fatigue in mouse single intact toe muscle fibres. Acta Physiologica, 186:59-66.
18.Pinniger, G.J., Bruton, J.D., Westerblad, H. & Ranatunga, K.W. (2005). Effects of a myosin-II inhibitor (N-benzyl-p-toluene sulphonamide, BTS) on contractile characteristics of intact fast-twitch mammalian muscle fibres. Journal of Muscle Research and Cell Motility, 26:135-141.
19.Coupland, M.E., Pinniger, G.J. & Ranatunga, K.W. (2005). Endothermic force generation, temperature-jump experiments and effects of increased [MgADP] in rabbit psoas muscle fibres. Journal of Physiology, 567(2):471-492.
20.Coupland, M.E., Pinniger, G.J. & Ranatunga, K.W. (2005). Tension responses to rapid (laser) temperature-jumps during twitch contractions in intact rat muscle fibres. Journal of Muscle Research and Cell Motility, 26:113-122.
21.Pinniger, G.J., Steele, J.R. & Cresswell, A.G. (2003). The force-velocity relationship of the human soleus muscle during submaximal voluntary lengthening actions. European Journal of Applied Physiology, 90(1-2):191-198.
22.Pinniger, G.J., Nordlund, M.M., Steele, J.R. & Cresswell, A.G. (2001). H-reflex modulation during lengthening and shortening actions of the human triceps surae. Journal of Physiology, 534(3):913-923.
23.Pinniger, G.J., Steele, J.R., Thorstensson, A., & Cresswell, A.G. (2000). Tension regulation during lengthening and shortening actions of the human soleus muscle. European Journal of Applied Physiology, 81(5):375-383.
24.Pinniger, G.J., Steele, J.R., & Groeller, H. (2000). Does fatigue induced by repeated dynamic efforts affect hamstring muscle function? Medicine and Science in Sports and Exercise, 32(3):647-653.
- Funding received
- NHMRC Project Grants
NHMRC Equipment Grants
Raine Priming Grant
UWA Research Grant
- The Australian Physiological Society
The Physiological Society (UK)
European Society for Muscle Research
- Honours and awards
- New Investigator Award in Clinical Science
Guest Research Scholarship for the Swedish Institute
NSW Sporting Injuries Committee Best New Research Talent in Science and Medicine in Sport
- Dr Pinniger is the Physiology Honours coordinator and course coordinator for PHYL3001 Muscles, Membranes and Signalling.
He also lectures in the following courses:
PHYL3002 Physiology of Cardiovascular and Respiratory Systems
PHYL3003 Physiology of Nutrition and Metabolism
PHYL2002 Physiology of Cells
SCIE1106 Molecular Biology of the Cell
DENT4101 Anatomy, Physiology and Cell Biology
DENT4107 Introduction to Pain Control
ANHB4103 Normal Systems I
PODI4107 Normal Systems II
- Current projects
- •The susceptibility to ventilator-induced diaphragm dysfunction in the pre-term lamb.
•Skeletal muscle physiology - molecular mechanisms of stretch-induced force enhancement and adaptation to exercise-induced muscle damage;
•Physiological evaluation of therapeutic and genetic treatments for muscular dystrophy;
•The role of protein thiol oxidation and inflammatory cytokines in muscle weakness associated with injury, ageing and disease.
Prof Jane Pillow, Centre for Neonatal Research and Education, and School of Anatomy, Physiology and Human Biology, UWA.
Dr Anthony Bakker, School of Anatomy, Physiology and Human Biology, UWA
Assoc Prof Peter Arhtur, School of Chemistry and Biochemistry, UWA
Prof. Miranda Grounds, School of Anatomy, Physiology and Human Biology, UWA
Prof. Steve Wilton & Dr Sue Fletcher, Australian Neuromuscular Research Institute (ANRI)
- Research profile
Research profile and publications