Professor Howard Mitchell
Senior Honorary Research Fellow
Anatomy, Physiology and Human Biology, School of
- Contact details
- School of Anatomy, Physiology and Human Biology
The University of Western Australia (M309)
35 Stirling Highway
CRAWLEY WA 6009
- PhD W.Aust.
- Professor Howard Mitchell sat his membership examinations for the Institute of Biology at London Polytechnic and Chelsea College. He completed his PhD at UWA before taking a Fellowship position at the John Curtin School of Medical Research at the Australian National University. Prof Mitchell then lectured at the University of Sheffield in England. He moved back to UWA in 1984 to continue his teaching and reseach. Prof Mitchell was recently an invited speaker at a number of specialist international meetings and most recently gave a Keynote Address at the International Symposium on Smooth Muscle.
Prof Mitchell has taken sabbatical leave at the Univeristy of Pennsylvania, Philadelphia, Kings College London, and the National Heart and Lung Institute, London.
- Key research
- As a respiratory physiologist, Prof Mitchell researches the control of the bronchial tree and airways, especially in diseases such as athsma. His interests include structure-function relationships, neural and pharmacological control of airway smooth muscle and the lung development.
- Healthy people subconciously control their airways by taking a deep breath every few minutes to keep the airways open. However, this does not occur in people with asthsma or other lung diseases. Prof Mitchell's current research aims to understand exactly how and why this occurs. Most reseach up to this point has been undertaken on animal models, but research is now beginning that will test out some of their hypotheses of lung disease using lungs donated by surgical patients. This could potentially lead to improved understanding and treatment of lung disease.
- Dr Peter McFawn, Lecturer, Discipline of Physiology, BBCS, UWA
- Prof Alan James, adjunct Associate Professor in Medicine and Pharmacology and consultant physician at QEII
- Prof Kenneth Lutchen, Department of Biomedical Engineering, University of Boston
- Woisin, F.E. Herd, C.M., Douglas, G.J., Raynor, K., Spina, D., Mitchell, H.W., Page, C.P. Relationship of airway responsiveness with airway morphometry in normal and immunized rabbits, Pulmonary Pharmacology and Therapeutics 14: pp 75-83 (2001)
Turner, D.T., Gray, P., Taylor, S., Thomas, J., Mitchell, H.W. Physiological responses of the airway wall and lung in hyperresponsive pigs, European Respiratory Journal, 18: pp 935-941 (2001)
Noble, P.B., Turner, D.J., Mitchell, H.W. Relationship of airway narrowing, compliance, and cartilage in isolated bronchial segments, Journal of Applied Physiology 92: pp 1119-1124 (2002)
Turner, D.J., Noble, P.B., Mitchell, H.W. Decreased airway narrowing and smooth muscle contraction in hyperresponsive pigs, Journal of Applied Physiology 93: pp 1296-1300 (2002)
Noble, P. B., McFawn, P. K. and Mitchell, H. W. Intralumenal pressure oscillation enhances subsequent airway contraction in isolated bronchial segments, Journal of Applied Physiology 96: pp 1161-1165 (2004)
Mitchell, H.W., Turner, D.J., Noble, P.B. Cholinergic responsiveness of the individual airway after allergen instillation in sensitised pigs. Pulmonary Pharmacology and Therapeutics 17(2): pp 81-8 (2004)
Khangure, S. R., Noble, P. B., Sharma, A., Chia, P. Y., McFawn, P. K. Mitchell, H. W. Cyclical elongation regulates contractile responses of isolated airways, Journal of Applied Physiology, 97: pp 913-919 (2004)
Bai, T.R., Bates, J.H., Brusasco, V., Camoretti-Mercado, B., Chitano, P., Dowell, M., Fabry, B., Ford, L.E., Fredberg, J.J., Gerthoffer, W.T., Gilbert, S.S., Gunst, S.J., Hai, C.M., Halayko, A.J., Hirst, S.J., James, A.L., Janssen, L.J., Jones, K.A., King, G.G., Lakser, O.J.,Lambert, R.K., Lauzon, A.M., Lutchen, K.L., Maksym, G.N., Meiss, R.A., Mitchell, H.W., Mitchell, R.W. Mitzner, W., Murphy, T.M., Paré, P.D., Schellenberg, R.R., Seow, C.Y., Sieck, G.C., Smith, P.G., Smolensky, A.V., Solway, J., Stephens, N.L., Stewart, A.G., Tang, D.D., Wang, L. On the terminology for describing the length-force relationship and its changes in airway smooth muscle, Journal of Applied Physiology, 97:2029-34 (2004)
Noble, P.B., Sharma, A., McFawn, P.K., Mitchell, H.W. Airway narrowing in porcine bronchi with and without lung parenchyma, European Respiratory Journal, 26: pp 804-11 (2005)
Noble, P. B., Sharma, A., McFawn, P. K. and Mitchell, H. W. Elastic properties of the bronchial mucosa: epithelial unfolding and stretch in response to airway inflation, Journal of Applied Physiology, 99: pp 2061-6 (2005)
Sharma, A., Goh, H. L., Asokananthan, N., Bakker, A., Stewart, G. A., and Mitchell, H. W. Delayed and persistent suppression of bronchoconstriction by trypsin in the airway lumen, European Respiratory Journal, 27: pp 20-8 (2006)
An, S.S., Bai, T.R., Bates, J.H.T., Black, J.L., Brown, R.H., Brusasco, V., Chitano, P., Deng, L., Dowell, M., Eidelman, D.H., Fabry, B., Fairbank, N.J., Ford, L.E., Fredberg, J.J., Gerthoffer, W.T., Gilbert, S.H., Gosens, R., Gunst, S.J., Halayko, A.J., Ingram, R.H., Irvin, C.G., James, A.L., Janssen, L.J., King, G.G., Knight, D.A., Lauzon, A.M., Lakser, O.J., Ludwig, M.S., Lutchen, K.R., Maksym, G.N., Martin, J.G., Mauad, T., McParland, B.E., Mijailovich, S.M., Mitchell, H.W., Mitchell, R.W., Mitzner, W., Murphy, T.M., Paré, P.D., Pellegrino, R., Sanderson, M.J., Schellenberg, R.R., Seow, C.Y., Silveira, P.S.P., Smith, P.G., Solway, J., Stephens, N.L., Sterk, P..J, Stewart, A.G., Tang, D.D., Tepper, R.S., Tran, T., Wang, L. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma, European Respiratory Journal, 29: pp 834-60 (2007)
Noble, P.B., McFawn, P.K., Mitchell, H.W.Responsiveness of the isolated airway during simulated deep inspirations: effect of airway smooth muscle stiffness and strain, Journal of Applied Physiology, 103: pp 787-95 (2007)
Laprad, A.S., West, A.R., Noble, P.B., Lutchen, K.R., Mitchell, H.W. Maintenance of airway caliber in isolated airways by deep inspiration and tidal strains, Journal of Applied Physiology, Epub ahead of print (2008)
- Funding received
- The laboratory has received nearly continuous funding from NH&MRC since the late 1980's. Further support has been provided by the Asthma Foundation of WA.
- British Phamalogical Society
American Thoracic Society
European Respiratory Society
- PHYL2255 Physiology of Human Body Systems
PHYL3350 Physiological Control Methods
IMED1100 Normal Systems
- Research profile
Research profile and publications