The University of Western Australia

UWA Staff Profile

Ipsum Lorem

Peter LeSouëf

Professor Peter LeSouëf

Head of School/Professor (Asthma Genetics Research)
Paediatrics

Contact details
Address
Paediatrics
The University of Western Australia (M561)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 9340 8173
Fax
+61 8 9388 2097
Email
peter.lesouef@uwa.edu.au
Qualifications
MD W.Aust., MRCP(UK), FRACP
Biography
Education and training
•MBBS (UWA) 1966-71, MRCP(UK) 1976, FRACP 1980, MD 1984
•paediatrics: University College Hospital, London 1974-75, neonatal research fellow 1976-77
•respiratory physiology research fellow: Hospital for Sick Children, Toronto 1981-82
•respiratory research fellow: Royal Children’s Hospital, Melbourne 1983-84
•molecular genetics sabbatical: University of Oxford, UK 1991

Employment
•Winthrop Professor of Paediatrics, University of Western Australia (UWA); 1998-present.
•Head, School of Paediatrics and Child Health (SPACH), UWA: 1998-2001, 2004 to present
•Head, Immunogenetics Research Group, SPACH, UWA
•Respiratory Physician, Founding Head, Department of Respiratory Medicine, PMH, Perth, WA
Key research
Previous research profile and leadership include establishing several new research initiatives:
•infant respiratory function: designed/implemented innovative techniques: single breath technique in neonates and raised volume forced expiratory method for measuring infant lung function
•Perth Children’s Aerosol Research Group: founded this group which has made the greatest international contribution to outlining the science of aerosol drug delivery in children.
•Immunogenetics Research Group: from 1992 with Prof Jack Goldblatt - all aspects of asthma genetics research; this expertise has led to vaccine, measles, malaria and HIV research in Africa
•human evolution: defined effect of geoclimatic factors on human immune system evolution
•raised > $15 million in competitive research grants and grants from industry
Current research profile and leadership
•current studies focus on mechanisms involved in acute respiratory virus infections in early life, and how these affect the immune system, airway microbiome and the later development of asthma
•asthma in children: viruses, immunology and microbiome – team has discovered that human rhinovirus group C is: main cause of severe children’s asthma; causes majority of acute attacks; most common cause of wheeze in < 2yr olds; only respiratory virus related to atopy
•immunogenetics: asthma, allergy, HIV (Gates grant - Africa), early respiratory infections (Africa)
•epigenetics: Finland/Russia, Greenland/Denmark Inuits, maternal in utero contribution to infant
Publications
230 publications in peer-reviewed journals
24 book chapters
SELECTED RECENT PUBLICATIONS
202.Zhang G, Candelaria P, Mäkelä M, Khoo S-K, Hayden C, Hertzen L, Laatikainen T, Vartiainen E, Goldblatt J, Haahtela T, Le Souëf PN. Disparity of innate immunity-related gene effects on asthma and allergy in Karelia. Pediatric Allergy and Immunology 2011 Sep;22(6):621-30.
204.Hayden CM, Zhang G, Judge PK, Khoo S-K, Laing IA, Turner SW, Goldblatt J, Holt PG, Le Souëf PN. Regulatory role of genetic variations in the IL-10 promoter on allergen-induced Th2 cytokine responses in children. J Allergy Clin Immunol 2011; 128:237-239
207.Bizzintino J, Lee W-M, Laing IA, Vang F, Pappas T, Zhang G, Geelhoed GC, Goldblatt J, Gern JE, Le Souëf PN. Association between human rhinovirus C and severity of acute asthma in children. Eur Resp J 2011; 37:1037-42
210.Rueter K, Bizzintino J, Martin AC, Zhang G, Geelhoed GC, Goldblatt J, Laing IA, Le Souëf PN. Symptomatic viral infection is associated with impaired response to treatment in children with acute asthma. J Pediatr 2012 Jan;160:82-7.
222.Clifford HD, Hayden CM, Khoo SK, Naniche D, Mandomando IM, Zhang G, Richmond P, Le Souëf PN. Polymorphisms in key innate immune genes and their effects on measles vaccine responses and vaccine failure in children from Mozambique. Vaccine 2012;30(43):6180-5.
229.Cox CW, Bizzintino J, Ferrari G, Khoo S-K, Zhang G, Whelan S, Lee WM, Bochkov YA, Geelhoed GC, Goldblatt J, Gern JE, Laing IA, Le Souëf PN. HRV-C Infection in Young Children with Acute Wheeze is Associated with Increased Acute Respiratory Hospital Admissions. Am J Respir Crit Care Med (in press – accepted 2 August 2013).
Roles, responsibilities and expertise
•Head, School of Paediatrics and Child Health (SPACH), UWA: 1998-2001, 2004 to present
•Head, Immunogenetics Research Group, SPACH, UWA
Future research
Mechanisms of acute viral respiratory infections in children
Immunogenetics of HIV infections in adults and children
Predictions of population growth of health in children
Funding received
Current NHMRC funding:
•51.Sly PD, Holt PG, Le Souëf PN, Tang M “Winter-only treatment with omalizumab to prevent asthma exacerbations in children” NHMRC #APP1021316
$738,329 NHMRC project grant2012-14
•52. Le Souëf PN, Goldblatt J, Currie A, Landau L, Hayden C. “Longitudinal characterization of respiratory and immune development from birth to adulthood” NHMRC # APP1031635 $510,373 NHMRC project grant2012-14
•54. Le Souëf PN, Currie A, Bizzintino J, Smith D, Cookson W, Gern J, Geelhoed G, Hales B, Khoo S-K. “Investigation into host susceptibility and immune responses in young children with acute wheezing due to human rhinovirus group C infection” NHMRC # APP1045760
$658,890 NHMRC project grant2013-15

Current non-NHMRC funding: includes:
•55.Naniche D, Blanco J,…. Le Souëf P. ‘Development of novel biomarkers distinguishing early HIV infection from longstanding infection in Sub-Saharan Africa”
Bill & Melinda Gates: total: $US1,013,466 Le Souëf component $US 191,452 2013-15
Industrial relevance
Has held 34 industry grants
Languages
English
Memberships
MEMBERSHIP OF PROFESSIONAL SOCIETIES

•American Thoracic Society
•Australian Medical Association
•Australasian Society of Clinical Immunology & Allergy
•European Respiratory Society
•International Society for Aerosols in Medicine
•Royal Australasian College of Physicians
•Thoracic Society of Australia and New Zealand
Honours and awards
AWARDS:
NATIONAL AWARD:
John Sands Medal 2007
Royal Australasian College of Physicians
for: “outstanding contribution to College affairs”
Presented in Melbourne6 May 2007

INTERNATIONAL AWARDS:
CIPP Founder President’s Award
for: “Distinguished Achievements in Pediatric Respiratory Sciences”
Congres International de Pneumologie Pediatrique
Presented in Nice, France 20 February 2002

International Society for Aerosols in Medicine (ISAM) Medal
for: role as President of the Organizing Committee of the
15th International Congress of ISAM 17 March 2005
Previous positions
EMPLOYMENT RECORD:
1972Resident Medical Officer - intern year
1973Senior Resident Medical Officer - ICU, anaesthetics
QUEEN ELIZABETH MEDICAL CENTRE, PERTH, WA

1973Senior Resident Medical Office - paediatrics
PRINCESS MARGARET HOSPITAL FOR CHILDREN, PERTH, WA

1974 - 1975House Physician - paediatrics (Prof LB Strang)
1975Senior House Officer - neonatology (Prof EOR Reynolds)
1976 - 1977Research Registrar - neonatology (Prof EOR Reynolds)
UNIVERSITY COLLEGE HOSPITAL, LONDON, UK

1978Senior Registrar - neonatology
KING EDWARD MEMORIAL HOSPITAL FOR WOMEN, PERTH, WA

1979Medical Registrar - paediatrics
1979 - 1980Senior Registrar - emergency, developmental, neonatology
PRINCESS MARGARET HOSPITAL FOR CHILDREN, PERTH, WA

1981 - 1983Research Fellow - respiratory physiology (Prof AC Bryan)
THE HOSPITAL FOR SICK CHILDREN, TORONTO, CANADA

1983 - 1984Research Fellow - paediatric respiratory medicine (Prof PD Phelan)
ROYAL CHILDREN'S HOSPITAL, MELBOURNE, VICTORIA

1984 - 1998Founding Head of Department
Department of Respiratory Medicine
PRINCESS MARGARET HOSPITAL FOR CHILDREN, PERTH, WA

1984 - presentConsultant Respiratory Physician
Department of Respiratory Medicine
PRINCESS MARGARET HOSPITAL FOR CHILDREN, PERTH, WA

1985 - 1992Senior Lecturer
Department of Paediatrics
UNIVERSITY OF WESTERN AUSTRALIA

1987 - 1990Head of Department
Department of Paediatrics
UNIVERSITY OF WESTERN AUSTRALIA

1991Visiting Research Fellow, Asthma Genetics Group
OXFORD UNIVERSITY, UK

1992 - 1993Acting Head of Department
Department of Paediatrics
UNIVERSITY OF WESTERN AUSTRALIA

1992 - 1998Associate Professor
Department of Paediatrics
UNIVERSITY OF WESTERN AUSTRALIA

1993 - presentHonorary Research Fellow
INSTITUTE OF CHILD HEALTH RESEARCH, PERTH, WA

1998 - 2001Head of Department
Department of Paediatrics
UNIVERSITY OF WESTERN AUSTRALIA

1998 - 2009Professor of Paediatrics
School of Paediatrics and Child Health
UNIVERSITY OF WESTERN AUSTRALIA

2004 - presentHead of School
School of Paediatrics and Child Health
UNIVERSITY OF WESTERN AUSTRALIA

2009 - presentWinthrop Professor of Paediatrics
School of Paediatrics and Child Health
UNIVERSITY OF WESTERN AUSTRALIA
Current projects
Mechanisms of acute viral respiratory infections in children
Immunogenetics of HIV infections in adults and children
Longitudinal assessment of the Perth Infant Asthma Follow-up Cohort - 24 yrs
Research profile
Research profile and publications
 

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Last updated:
Tuesday, 3 November, 2015 2:39 PM