The University of Western Australia

UWA Staff Profile

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Peter Noble

Dr Peter Noble

Senior Lecturer
Human Sciences, School of

Contact details
School of Human Sciences
The University of Western Australia (M309)
35 Stirling Highway
+61 8 6488 3314
+61 8 6488 1025

Senior Research Fellow
Neonatal Research and Education, Centre for

Contact details
Centre for Neonatal Research and Education
The University of Western Australia (M309)
35 Stirling Highway
+61 8 6488 3314
+61 8 6488 1025
BSc PhD W.Aust.
Dr Noble is an Assistant Professor in the School of Anatomy, Physiology and Human Biology (UWA, 2013-2016). His present research interests include the mechanisms and early life origins of obstructive airway disease including asthma and COPD, and the neonatal disorders, tracheobronchomalcia and bronchopulmonary dysplasia. Current funding includes an NHMRC Career Development Fellowship (2013-2016) and an NHMRC Project Grant.
Key research
Premature birth
Ventilator Induced Lung Injury
Bronchopulmonary dysplasia
1.Noble PB, Jones RL, Cairncross A, Elliot JG, Mitchell HW, James AL, et al. Airway narrowing and bronchodilation to deep inspiration in bronchial segments from subjects with and without reported asthma. J Appl Physiol. 2013; 114(10): 1460-71.
2.Lavin T, Song Y, Bakker AJ, McLean CJ, Macdonald WA, Noble PB, et al. Developmental changes in diaphragm muscle function in the preterm and postnatal lamb. Pediatr Pulmonol. 2013.
3.Chin L, Yang X, McLaughlin RA, Noble PB, Sampson DD. En face parametric imaging of tissue birefringence using polarization-sensitive optical coherence tomography. J Biomed Opt. 2013; 18(6): 66005.
4.Ansell TK, McFawn PK, Mitchell HW, Noble PB. Bronchodilatory response to deep inspiration in bronchial segments: the effects of stress versus strain. J Appl Physiol. 2013.
5.Wong RS, Larcombe AN, Fernandes LB, Zosky GR, Noble PB. The mechanism of deep inspiration-induced bronchoprotection: evidence from a mouse model. Eur Respir J. 2012; 40(4): 982-9.
6.West AR, Needi ET, Mitchell HW, McFawn PK, Noble PB. Airways dilate to simulated inspiratory but not expiratory manoeuvres. Eur Respir J. 2012; 40(2): 455-61.
7.Noble PB, Ansell TK, James AL, McFawn PK, Mitchell HW. Airway Smooth Muscle Dynamics and Hyperresponsiveness: In and outside the Clinic. J Allergy (Cairo). 2012; 2012: 157047.
8.McLaughlin RA, Yang X, Quirk BC, Lorenser D, Kirk RW, Noble PB, et al. Static and dynamic imaging of alveoli using optical coherence tomography needle probes. J Appl Physiol. 2012; 113(6): 967-74.
9.Quirk BC, McLaughlin RA, Curatolo A, Kirk RW, Noble PB, Sampson DD. In situ imaging of lung alveoli with an optical coherence tomography needle probe. J Biomed Opt. 2011; 16(3): 036009.
10.Noble PB, Jones RL, Needi ET, Cairncross A, Mitchell HW, James AL, et al. Responsiveness of the human airway in vitro during deep inspiration and tidal oscillation. J Appl Physiol. 2011; 110(6): 1510-8.
11.Zosky GR, Noble PB, Sly PD. Commentaries on Viewpoint: Standards for quantitative assessment of lung structure. Instillation fixation and overinflation of the mouse lung. J Appl Physiol. 2010; 109(3): 935; author reply 7.
12.Williamson JP, Armstrong JJ, McLaughlin RA, Noble PB, West AR, Becker S, et al. Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography. Eur Respir J. 2010; 35(1): 34-41.
13.Noble PB, West AR, McLaughlin RA, Armstrong JJ, Becker S, McFawn PK, et al. Airway narrowing assessed by anatomical optical coherence tomography in vitro: dynamic airway wall morphology and function. J Appl Physiol. 2010; 108(2): 401-11.
14.Noble PB, McLaughlin RA, West AR, Becker S, Armstrong JJ, McFawn PK, et al. Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography. Respir Res. 2010; 11: 9.
15.Noble PB, Hernandez JM, Mitchell HW, Janssen LJ. Deep inspiration and airway physiology: human, canine, porcine, or bovine? J Appl Physiol. 2010; 109(3): 938-9; author reply 40-1.
16.Cooper PR, McParland BE, Mitchell HW, Noble PB, Politi AZ, Ressmeyer AR, et al. Airway mechanics and methods used to visualize smooth muscle dynamics in vitro. Pulm Pharmacol Ther. 2009; 22(5): 398-406.
17.Ansell TK, Noble PB, Mitchell HW, West AR, Fernandes LB, McFawn PK. Effects of simulated tidal and deep breathing on immature airway contraction to acetylcholine and nerve stimulation. Respirology. 2009; 14(7): 991-8.
18.Ansell TK, McFawn PK, Noble PB, West AR, Fernandes L, Mitchell HW. Potent bronchodilation and reduced stiffness by relaxant stimuli under dynamic conditions. Eur Respir J. 2009; 33(4): 844-51.
19.LaPrad AS, West AR, Noble PB, Lutchen KR, Mitchell HW. Maintenance of airway caliber in isolated airways by deep inspiration and tidal strains. J Appl Physiol. 2008; 105(2): 479-85.
20.Noble PB, McFawn PK, Mitchell HW. Responsiveness of the isolated airway during simulated deep inspirations: effect of airway smooth muscle stiffness and strain. J Appl Physiol. 2007; 103(3): 787-95.
21.Noble PB, Sharma A, McFawn PK, Mitchell HW. Elastic properties of the bronchial mucosa: epithelial unfolding and stretch in response to airway inflation. J Appl Physiol. 2005; 99(6): 2061-6.
22.Noble PB, Sharma A, McFawn PK, Mitchell HW. Airway narrowing in porcine bronchi with and without lung parenchyma. Eur Respir J. 2005; 26(5): 804-11.
23.Noble PB, McFawn PK, Mitchell HW. Intraluminal pressure oscillation enhances subsequent airway contraction in isolated bronchial segments. J Appl Physiol. 2004; 96(3): 1161-5.
24.Mitchell HW, Turner DJ, Noble PB. Cholinergic responsiveness of the individual airway after allergen instillation in sensitised pigs. Pulm Pharmacol Ther. 2004; 17(2): 81-8.
25.Khangure SR, Noble PB, Sharma A, Chia PY, McFawn PK, Mitchell HW. Cyclical elongation regulates contractile responses of isolated airways. J Appl Physiol. 2004; 97(3): 913-9.
26.Turner DJ, Noble PB, Lucas MP, Mitchell HW. Decreased airway narrowing and smooth muscle contraction in hyperresponsive pigs. J Appl Physiol. 2002; 93(4): 1296-300.
27.Noble PB, Turner DJ, Mitchell HW. Relationship of airway narrowing, compliance, and cartilage in isolated bronchial segments. J Appl Physiol. 2002; 92(3): 1119-24.

Roles, responsibilities and expertise
Assistant Research Professor
PhD supervisor
Funding received
2013-2016, Career Development Fellowship (APP1045824, $404,884), ‘Structural and mechanical determinants of airway hyperresponsiveness’
2012-2014, Project grant (APP1027218, $396,250), ‘Airway smooth muscle and asthma’
2008-2011, Fellowship (APP513921, $286,016), ‘Investigation on whether changes in lung stretch contributes to respiratory disease’
2008-2010, Project grant (APP513842, $281,037), ‘Response of Human Airways to Deep Inflation in Health and Disease’
2011, Equipment grant ($52,000), ‘Casmed ForeSight monitor X2 for absolute cerebral and tissue oximetry’
2011, Equipment grant ($45,000), ‘Visiopharm new CAST software and stereology microscope’
2007, Equipment grant ($37,000), ‘Leica ASP-200 automated vacuum tissue processor’

2013-2015, BrightSpark Foundation Fellowship ($437,595.4) NB: fellowship returned following receipt of NHMRC CDF
2012, MHRIF – infrastructure grant ($14,321)
2011, UWA Near miss grant ($70,000)
2010, UWA Research development award ($23,052)
2007-2008, Raine medical research foundation ($129,458)

Thoracic Society of Australia and New Zealand
American Thoracic Society
NHMRC Postdoctoral Reference Group

Honours and awards
2010 Raine Research Prize
‘Elastic properties of the bronchial mucosa: Epithelial unfolding and stretch in response to airway inflation’
Previous positions
Research Fellow, Telethon Institute for Child Health Research
Research profile
Research profile and publications

The University of Western Australia

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Last updated:
Tuesday, 3 November, 2015 2:39 PM