The University of Western Australia

UWA Staff Profile

Ipsum Lorem

David Hunt

Professor David M Hunt

Honorary Research Fellow
Animal Biology, School of

Contact details
Address
School of Animal Biology
The University of Western Australia (M085)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 6488 3044
Fax
+61 8 6488 7527
Email
david.hunt@uwa.edu.au
Location
Old AVA Building adjacent to Zoology Building, Perth campus
Qualifications
BSc PhD Sheff.
Biography
Professor David Hunt graduated with a BSc in Zoology in 1964 followed by a PhD in Genetics in 1967, both from the University of Sheffield, UK. After several moves, he took a lectureship in 1974 at Queen Mary College, University of London, but it was not until 1988 that he moved his research interest into the field of visual science. This led to a move in 1992 to the UCL Institute of Ophthalmology in London, with a final move to the University of Western Australia in 2010. His early work in vision was largely confined to the molecular evolution of primate colour vision but he has subsequently looked at colour vision in a range of animal species that include the lampreys, a number of deep sea fish species, limbless amphibians, snakes, several species of birds, and a number of mammals. The latter extend from new and old world monkeys, lemurs and dolphins to the monotremes (platypus) and marsupials. He has also worked closely with Moorfields Eye Hospital in London and has been responsible for the identification of the genes and mutations that are responsible for a number of inherited blinding disorders in human patients.
Key research
1. Molecular genetics of inherited retinal diseases - identification of disease genes and mutations and functional analysis of mutant proteins using a combination of in vitro analysis and mouse modelswhole animal studies.
2. Comparative studies on the evolution of vision in vertebrates. Studies extend from colour vision defects in humans, the molecular evolution of colour vision in primates, marsupials, monotremes, rodents and cetaceans, the visual pigment evolution in snakes, the molecular basis for dim light vision, and the origin of colour vision and the different components of the visual cycle in early vertebrates.
Publications
Books

1.Stewart, A. and Hunt, D. M. (1983) The Genetic Basis of Development. Blackie, Glasgow.
2.Röhl, J. C. G., Warren, M. J. and Hunt, D. M. (1998) Purple Secret. Genes,‘Madness’, and the Royal Houses of Europe. Bantam Press, London.

Book chapters

3.Fitzgibbon, J. and Hunt, D. M. (1995) Drosophila visual transduction, a model system for human eye disease? In Degenerative Diseases of the Retina (Edited by Anderson, Holyfield and Le Vail), pp. 255-261. Plenum Press: New York.
4.Govardovskii, V., Shukolyukov, S., Zueva, L., Sideleva, V. G., Smirnova, O. G., Bowmaker, J. K. and Hunt, D. M. (1996) Photoreceptors and visual pigments of Baikal Cottoidei. In "XI Conference on Evolutionary Physiology", pp. 49-50. Nauka: St Petersburg.
5.Mollon, J. D., Dulai, K. and Hunt, D. M. (1997) Dalton's colour blindness: an essay in molecular biography, in John Dalton’s Colour Vision Legacy (eds C. Dickinson, I. Murray and D. Carden), pp. 15-33, Taylor and Francis, London.
6.Bowmaker, J. K., Hunt, D. M. and Mollon, J. D. (1997) Primate visual pigments: their spectral distribution and evolution, in John Dalton’s Colour Vision Legacy (eds C. Dickinson, I. Murray and D. Carden), pp. 37-46, Taylor and Francis, London.
7.Bowmaker, J. K. and Hunt, D. M. (1999) Genetics of photoreceptor sensitivity adaptation. In Adaptive mechanisms in the ecology of vision, Archer, S. N., Djamgoz, M. B. A., Loew, E., Partridge, J. C. and Vallerga, S. (eds), Chapman and Hall, London.
8.Hunt, D. M. (2001) Color Blindness In S. Brenner and J. H. Miller (eds), Encylcopedia of Genetics, Academic Press.
9.Newbold, R., Deery, E. C., Payne, A., Wilkie, S. E., Hunt, D. M. and Warren, M. J. (2002), Guanylate cyclase-activating proteins, guanylate cyclase and disease. In Photoreceptors and Calcium, Baehr, W. and Palczewski, K. (eds.). pp 411- 421. Kluwer Academic/Plenum Publishers, New York.
10.Douglas, R. H., Hunt, D. M. and Bowmaker, J. K. (2003) Spectral sensitivity tuning in the deep-sea. In: S.P Collin & N. J. Marshall (eds), Sensory Processing of the Aquatic Environment, pp. 323-342. Springer-Verlag, New York.
11.Hunt, D. M., Jacobs, G. H. and Bowmaker, J. K. (2005) The genetics of primate visual pigments. In: J. Kremers (ed), The Primate Visual System: A Comparative Approach, pp. 73-97. John Wiley & Sons, Ltd, Chichester.
12.Hunt, D. M. and Bowmaker, J. K. (2006) Visual pigments and visual communication in deepwater environments. In: F. Ladich, S. P. Collin, P. Moller and B. G. Kapoor (eds), Communication in Fishes, pp. 453-479. Science Publishers, Inc., USA.
13.Beazley, L. D., Arrese, C. and Hunt, D. M. (2010) Visual system. In The Neurobiology of Australian Marsupials, K. W. S. Ashwell, editor. Pp 155-166. Oxford University Press, Oxford.
14.Hunt, D. M. (2013) Color vision and color blindness. In S. Maloy and K. Hughes (eds.), Brenner's Online Encyclopedia of Genetics 2E, Academic Press. (In press).
15.Hunt, D. M., Hart, N. S. and Collin, S. P. (2013) Sensory systems. In F. Trischitta, Y. Takei and A. Damasceno-Oliveira (eds), Eel Physiology, Science Publishers, Enfield, New Hampshire, USA.

Biography

16.Lewis, D. and Hunt, D. M. (1984) Hans Grüneberg. Memoirs of the Royal Society 30, 225-248.

Peer-reviewed Conference Proceedings, Invited Reviews and Commissioned Reports

17.Hunt, D. M. (1980) Copper and neurological function. In Biological roles of copper. Ciba Symposium 79, 247-260.
18.Joshua, S., Hunt, D. M. and Parker, J. S. (1989) Solution to bird sex. Cock or Hen? Feathers hold the key. Cage and Aviary Birds.
19.Bowmaker, J. K. and Hunt, D. M. (1990) Genes and colour blindness. Lancet 335, 263-264.
20.Hunt, D. M. (1992) The application of DNA fingerprinting in aviculture. Avicultural and Veterinary Conference, 73-80.
21.Dulai, K. S., Mollon, J. D. and Hunt, D. M. (1995) Molecular biography of John Dalton: The chemical basis of his color blindness. Biosystems Reporter 25, 3-4.
22.Warren, M. J., Jay, M., Hunt, D. M., Elder, G. and Rohl, J. (1996) The maddening business of King George III and porphyria. Trends in Biochemistry 21, 229- 234
23.Ali, R. R., Reichel, M. B., Kanuga, N., Clarke, A. R., Luthert, P. J., Bhattacharya, S. S. and Hunt, D. M. (1998) Gene therapy for inherited retinal degeneration. British J. Ophthalmology 81, 795-801.
24.David-Gray, Z. K., Gurnell, J. and Hunt, D. M. (1998) An investigation into the use of DNA fingerprinting in determining the mating system and reproductive success of the grey squirrel, Sciurus carolinensis, in The Ecology and Evolutionary Biology of Tree Squirrels (eds. M. A. Steele, J. F. Merritt and D. A. Zegers), pp 320, Special Publication, Virginia Museum of Natural History.
25.Reichel, M. B., Ali, R. R., Hunt, D. M. and Bhattacharya, S. S. (1998) Gene therapy for retinal degeneration. Ophthalmic Research 29, 261-268.
26.Bowmaker, J. K., Wilkie, S. E. and Hunt, D. M. (1999). Photoreceptors and molecular genetics of visual pigments in birds. In Adams, N. J., Slotow, R. H. (ed.) Proceedings of the 22nd International Ornithological Congress, Durban. Johannesburg: Bird Life South Africa, 2729-2742.
27.Hunt, D. M. (2001) Molecular evolution of trichromacy in primates. The Biologist 48, 67-71.
28.Hunt, D. M., Wilkie, S. E., Bowmaker, J. K. and S. Poopalasundaram (2001) Vision in the Ultraviolet. Cellular and Molecular Life Sciences 58, 1583-1598.
29.Michaelides, M., Hunt, D. M. and Moore, A. T. (2003) The genetics of inherited macular dystrophies. Journal of Medical Genetics 40, 641-650.
30.Hunt, D. M., Wilkie, S. E., Newbold, R., Deery, E., Warren, M. J., Bhattacharya, S. S. and Zhang, K. (2004) Dominant cone and cone-rod dystrophies: functional analysis of mutations in retGC1 and GCAP1. In Retinal dystrophies: functional genomics to gene therapy. Novartis Foundation Symposium no. 255, pp37-50.
31.Hunt, D. M., Cowing, J. A., Wilkie, S. E., Parry, J., Poopalasundaram, S. and Bowmaker, J. K. (2004) Divergent mechanisms for the tuning of shortwave sensitive visual pigments in vertebrates. Photochemical and Photobiological Sciences 3, 713 - 720.
32.Michaelides, M., Hardcastle, A. J., Hunt, D. M. and Moore, A. T. (2006) Progressive cone and cone-rod dystrophies: Phenotypes and underlying molecular genetic basis. Survey of Ophthalmology 51, 232-258.
33.Bowmaker, J. K. and Hunt, D.M. (2006) Evolution of visual pigments. Current Biology 16, R484-489.
34.Hart, N. J. and Hunt, D. M. (2007) Avian visual pigments: characteristics, spectral tuning and evolution. American Naturalist 169, S7–S26.
35.Hunt, D. M., Carvalho, L. S., Cowing, J. A., Parry, J. W. L., Wilkie, S. E., Davies, W. L. and Bowmaker, J. K. (2007) Spectral tuning of shortwave-sensitive visual pigments in vertebrates. Photochemistry and Photobiology 83, 303-310.
36.Davies, W. L., Carvalho, L. S. and Hunt, D. M. (2009) SPLICE: a technique for generating in vitro spliced coding sequences from genomic DNA. Biotechniques Protocol Guide 67- 72.
37.Hunt, D. M., Carvalho, L. S., Davies, W. L. and Cowing, J. A. (2009) Evolution and spectral tuning of visual pigments in birds and mammals. In Evolution of Phototransduction and Eyes, Philosophical Transactions B. 364, 2941-2955.
38.Collin, S. P., Davies, W. L., Hart, N. S. and Hunt, D. M. (2009) The evolution of early vertebrate photoreceptors. In Evolution of Phototransduction and Eyes, Philosophical Transactions B. 364, 2925-2940.
39.Hunt, D. M., Michelaides, M. and Buch, P. (2009) Guanylate cyclase activity and inherited eye disease. In Guanylate cyclase: Past, present and future (ed. R K Sharma). Molecular and Cellular Biochemistry 334, 157-168.
40.Davies, W. L., Collin, S. P., and Hunt, D. M. (2012) Molecular ecology and adaptation of visual photopigments in craniates. Molecular Ecology 21, 3121-3158.
41.Hunt, D. M. and Peichl, L. (2014) S cones: Evolution, retinal distribution, development and spectral sensitivity. Visual Neuroscience 31, 115-138.

Refereed articles/papers

42.Hunt, D. M. (1967) Physiological genetics of the eyeless and eyegone mutants of Drosophila melanogaster. Ph.D. Thesis.
43.Hunt, D. M. and Burnet, B. (1969) Gene-environment interactions of the eyeless mutant in Drosophila melanogaster. Genetical Research 13, 251-265.
44.Hunt, D. M. and Burnet, B. (1969) Gene-environment interactions of the eyegone mutant in Drosophila melanogaster. Genetical Research 13, 313-320.
45.Hunt, D. M. (1970) Lethal interactions of the eyeless and eyegone mutants in Drosophila melanogaster. Genetical Research 15, 29-34.
46.Hunt, D. M. (1970) A comparison of the effect of acid amides supplemented to yeasted and sterile synthetic culture on the Bar phenotype. Drosophila Information Service 45, 137.
47.Hunt, D. M. (1971) A haemolymph protein anomaly associated with the lethal-giant larvae mutant in Drosophila melanogaster. Drosophila Information Service 47, 119-120.
48.Hunt, D. M. (1971) The physiological control of gene action in the eyeless and eyegone mutants of Drosophila melanogaster. Genetical Research 17, 195-208.
49.Hunt, D. M. and Johnson, D. R. (1971) Abnormal spermiogenesis in two pink-eyed sterile mutants in the mouse. J. Embryology and Experimental Morphology 26, 111-121.
50.Johnson, D. R. and Hunt, D. M. (1971) Hop-sterile, a mutant gene affecting sperm tail development in the mouse. J. Embryology and Experimental Morphology 25, 223-236.
51.Hunt, D. M. and Johnson, D. R. (1972) Aromatic amino acid metabolism in brindled (Mobr) and viable-brindled (Movbr), two alleles at the mottled locus in the mouse. Biochemical Genetics 6, 31-40.
52.Hunt, D. M. and Johnson, D. R. (1972) An inherited deficiency in noradrenaline biosynthesis in the brindled mouse. Journal of Neurochemistry 19, 2811-2819.
53.Crawfurd, M. d'A., Dean, M. F., Hunt, D. M., Johnson, D. R., MacDonald, R. R., Muir, H. and Payling-Wright, C. R. (1973) Early pre-natal diagnosis of Hurler's syndrome with termination of pregnancy and confirmatory findings on the foetus. Journal of Medical Genetics 10, 144-153.
54.Hunt, D. M. (1974) Primary defect in copper transport underlies mottled mutants in the mouse. Nature 249, 852-854.
55.Johnson, D. R. and Hunt, D. M. (1974) Biochemical observations on the cartilage of achondroplastic (can) mice. J. Embryology and Experimental Morphology 31, 319-328.
56.Johnson, D. R. and Hunt, D. M. (1974) Endocrinological findings in sterile pink-eyed mice. J. Reproduction and Fertility 42, 51-58.
57.Sewell, D. R., Hunt, D. M. and Burnet, B. (1975) Biogenic amines in Drosophila melanogaster selected for differences in larval feeding behaviour. Behavioural Biology 15, 213-217.
58.Hunt, D. M. (1976) A study of copper transport and tissue copper levels in the murine congenital copper deficiency, mottled. Life Sciences 19, 1913-1920.
59.Hunt, D. M. (1977) Catecholamine biosynthesis and the activity of a number of copper-dependent enzymes in the copper deficient mottled mouse mutants. Comparative Biochemistry and Physiology 57C, 79-83.
60.Hunt, D. M. and Port, A. E. (1979) Trace element binding in the copper deficient mottled mutants in the mouse. Life Science 24, 1453-1466.
61.Port, A. E. and Hunt, D. M. (1979) A study of the copper-binding proteins in liver and kidney tissue of neonatal normal and mottled mutant mice. Biochemical Journal 183, 721-730.
62.Blass, D. and Hunt, D. M. (1980) Pyrimidine biosynthesis in the dumpy mutants of Drosophila melanogaster. Molecular and General Genetics 178, 437-442.
63.Hunt, D. M. and Port, A. E. (1982) The distribution of copper in neonatal mottled mutant mice after exposure to copper and penicillamine. Life Science 31, 417-427.
64.Hunt, D. M. and Mhlanga, T. (1983) Genetic studies on metallothionein synthesis in the mouse. The induction of metallothionein by cadmium in inbred strains. Biochemical Genetics 21, 609-627.
65.Crane, I. and Hunt, D. M. (1983) A study of intestinal copper-binding proteins in mottled mice. Chemical-biological Interactions 45, 113-124.
66.Hunt, D. M. and Clarke, R. (1983) Metallothionein and the development of the mottled disorder in the mouse. Biochemical Genetics 21, 1175-1194.
67.Hunt, D. M., Wake, S., Mercer, J., Stephenson, T. and Danks, D. M. (1986) A study of the role of metallothionein in the inherited copper toxicosis of dogs. Biochemical J. 236, 409-415.
68.Movaghar, M. and Hunt, D. M. (1987) Tyrosinase activity and the production of phaeomelanin in agouti mice. J. Experimental Zoology 243, 473-480.
69.Prince, S. D., Willson, P., Hunt, D. M. and Halstead, P. (1988) An integrated camera and radiometer for aerial monitoring of vegetation. International J. of Remote Sensing 9, 303-318.
70.Farr, C. and Hunt, D. M. (1989) Genetic differences in zinc and copper induction of liver metallothionein in inbred strains of the mouse. Biochemical Genetics 27, 199-217.
71.Bowmaker, J. K., Astell, S., Hunt, D. M. and Mollon, J. D. (1991) Photosensitive and photostable pigments in the retinae of Old World monkeys. J. Experimental Biology 156, 1-19.
72.Balding, D. J., Nichols, R. A. and Hunt, D. M. (1992) Detecting gene conversion: primate visual pigment genes. Proceedings of the Royal Society B 249, 275-280.
73.Ibbotson, R. E., Hunt, D. M., Bowmaker, J. K. and Mollon, J. D. (1992) Sequence divergence and copy number of the middle- and long-wave photopigment genes in Old World monkeys. Proceedings of the Royal Society B 247, 145-154.
74.Williams, A. J., Hunt, D. M., Bowmaker, J. K. and Mollon, J. D. (1992) The polymorphic photopigments of the marmoset: spectral tuning and genetic basis. European Molecular Biology Organisation Journal 11, 2039-2045.
75.Hunt, D. M., Williams, A. J., Bowmaker, J. K. and Mollon, J. D. (1993) Structure and evolution of the polymorphic photopigment gene of the marmoset. Vision Research 33, 147-154.
76.Morris A., Bowmaker, J.K. and Hunt, D. M. (1993) The molecular basis of a spectral shift in the visual pigments of two species of squid from different photic environments. Proceedings of the Royal Society B 254, 233-240.
77.Fitzgibbon, J., Appukuttan B., Gayther, S., Wells, D., Delhanty, J. and Hunt, D. M. (1994) Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32. Human Genetics 93, 79-80.
78.Bowmaker, J. K., Govardovskii, V. I., Shukolyukov, S. A., Zueva, L. V., Hunt, D. M., Sideleva, V. G. and Smirnova, O. G. (1994) Visual pigments and the photic environment: the cottoid fish of Lake Baikal. Vision Research 34, 591-606.
79.Evans, K., Fryer, A., Inglehearn, C., Duvall-Young, J., Whittaker, J., Gregory, C. Y., Ebenezer, N., Hunt, D. M. and Bhattacharya, S. (1994) Genetic linkage of cone-rod retinal degeneration to chromosome 19q and evidence for segregation distortion. Nature Genetics 6, 210-213.
80.Fitzgibbon, J, Pilz, A., Gayther, S., Appukuttan, B., Dulai, K. S., Delhanty, J. D. A., Helmkamp, Jr, G. M., Yarbrough, L. R. and Hunt, D. M. (1994) Localization of the human phosphatidylinositol transfer protein (PITPN) to 17p13.3: a gene showing homology to the Drosophila retinal degeneration B gene (rdgB). Cytogenetics and Cell Genetics 67, 205-207.
81.Dulai, K. S., Bowmaker, J. K., Mollon, J. D. and Hunt, D. M. (1994) Sequence divergence, polymorphism and evolution of the middle-wave and long-wave visual pigment genes of Great Apes and Old World monkeys. Vision Research 34, 2483-2491.
82.Hunt, D. M., Dulai, K., Bowmaker, J. K. and Mollon, J. D. (1995) The Chemistry of John Dalton's Color Blindness. Science 267, 984-988.
83.Pilz, A., Schaap, D., Hunt, D. M. and Fitzgibbon, J. (1995) Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene. Genomics 26, 599-601.
84.Hunt, D. M., Cowing, J. A., Patel, R., Appukuttan, B., Bowmaker, J. K. and Mollon, J. D. (1995) Sequence and evolution of the blue cone pigment gene in Old and New World primates. Genomics 27, 535-538.
85.Fitzgibbon, J., Hope, A., Slobodyanyuk, S., Bellingham, J., Bowmaker, J. K. and Hunt, D. M. (1995) The rhodopsin gene of bony fish lacks introns. Gene 164, 273-277.
86.Shyue, S-K., Hewett-Emmett, D., Sperling, H. G., Hunt, D. M., Bowmkaker, J. K., Mollon, J. D. and Li, W-H. (1995) Adaptive evolution of color vision genes in higher primates. Science 269, 1265-1267.
87.Kelsell, R., Godley, B. F., Evans, K., Tiffin, P. A. C., Gregory, C. Y., Plant, C., Moore, A. T., Bird, A. C. and Hunt, D. M. (1995) Localization of a gene for progressive bifocal chorioretinal atrophy (PBCRA) to chromsome 6q. Human Molecular Genetics 4, 1653-1656.
88.Morris, A. G., Gaitonde, E., McKenna, P. J., Mollon, J. D. and Hunt, D. M. (1995) CAG repeat expansions and schizophrenia: association with disease in females and with early age-at-onset. Human Molecular Genetics 4, 1957-1961.
89.Fitzgibbon, J., Wells, D., Pilz, A., Delhanty, J., Kai, M., Kanoh, H. and Hunt, D. M. (1995) Localization of the gene encoding diacylglycerol kinase 3 (DAGK3) to human chromosome 3q28 and mouse chromosome 16. Current Eye Research 14, 1041-1043.
90.Yeh, T., Lee, B. B., Kremers, J., Cowing, J. A., Hunt, D. M., Martins, P. R. and Troy, J. B. (1995) Visual responses in the lateral geniculate nucleus of dichromatic and trichromatic marmosets (Callithrix jacchus). J. Neuroscience 15, 7892-7904.
91.Hunt, D. M., Fitzgibbon, J., Slobodyanyuk, S. and Bowmaker, J. K. (1996) Spectral tuning and molecular evolution of rod visual pigments in the species flock of Cottoid fish in Lake Baikal. Vision Research 36, 1217-1224.
92.Ali, R. R., Reichel, M. B., Thrasher, A. J., Levinsky, R. J., Kinnon, C., Kanuga, N., Hunt, D. M. and Bhattacharya, S. S. (1996) Gene transfer into the mouse retina mediated by an adeno-associated viral vector. Human Molecular Genetics 5, 591-594.
93.Fitzgibbon, J., Wells, D., Delhanty, J., Katsanis, N., Vallins, W. and Hunt, D. M. (1996) Human guanylate kinase (GUK1): cDNA sequence and chromosomal localisation. FEBS Letters 385, 185-188.
94.Godley, B. F., Tiffin, P. A. C., Evans, K., Kelsell, R. E., Hunt, D. M. and Bird, A. C. (1996) Clinical features of progressive bifocal chorioretinal atrophy: a retinal dystrophy linked to chromosome 6q. Ophthalmology 103, 893-898.
95.Gaitonde, E., Morris, A. G., Sivagnanasundaram, S., McKenna, P. J., Hunt, D. M. and Mollon, J. D. (1996) Assessment of association of D3 dopamine receptor MscI polymorphism with schizophrenia: Analysis of symptom ratings, family history, age at onset, and movement disorders. American Journal of Medical Genetics, 67, 455-458.
96.Hope, A. J., Partridge, J. C., Dulai, K. S. and Hunt, D. M. (1997) Mechanisms of wavelength tuning in the rod opsins of deep-sea fishes. Proceedings of the Royal Society B 264, 155-163.
97.Heath, L. A., Wilkie, S. E., Bowmaker, J. K. and Hunt, D. M. (1997) The rod and green cone opsins of two avian species, the budgerigar, Melopsittacus undulatus, and the mallard duck, Anas platyrhynchus. Gene 204, 121-126.
98.Gaitonde, E. J., Sivagnanasundaram, S., Morris, A. G., McKenna, P. J., Mollon, J. D. and Hunt, D. M. (1997) The number of triplet repeats in five brain-expressed loci with CAG expansions is not associated with schizophrenia. Schizophrenia Research 25, 111-116.
99.Bellingham, J., Wilkie, S. E., Morris, A. G., Bowmaker, J. K. and Hunt, D. M. (1997) Characterisation of ultraviolet-sensitive opsin gene in the honey-bee (Apis mellifera). European J Biochemistry 243, 775-781.
100.Kelsell, R., Evans, K., Gregory, C. Y., Moore, A. T., Bird, A. C. and Hunt, D. M. (1997) Localization of a gene for dominant cone-rod dystrophy (CORD6) to chromosome 17p. Human Molecular Genetics 6, 597-600.
101.Bowmaker, J. K., Heath, L. A., Wilkie, S. E. and Hunt, D. M. (1997) Visual pigments and oil droplets from six classes of photoreceptor in the retinas of birds. Vision Research 37, 2183-2194.
102.Hunt, D. M., Fitzgibbon, J., Slobodyanyuk, S. J. and Bowmaker, J. K. (1997) Molecular evolution of the cottoid fish endemic to Lake Baikal deduced from nuclear DNA evidence. Molecular Phylogenetics and Evolution 8, 415-422.
103.Boissinot, S., Zhou, Y-H., Qiu, L., Dulai, K. S., Neiswanger, K., Schneider, H., Sampaio, I., Hunt, D. M., Hewett-Emmett, D. and Li, W-H. (1997) Origin and molecular evolution of the X-linked duplicate color vision genes in Howler monkeys. Zoological Studies 36, 360-369.
104.Reichel, M. B., Ali, R. R., Hunt, D. M. and Bhattacharya, S. S. (1997) Gene therapy for retinal degeneration. Ophthalmic Research 29, 261-268.
105.Reichel, M. B., Ali, R. R., D’Esposito, F., Clarke, A. R., Luthert, P. J., Bhattacharya, S. S. and Hunt, D. M. (1998) High frequency of hyperplastic primary vitreous in p53-deficient mice. Cell Death and Differentiation 5, 156-162.
106.Wilkie, S. E., Vissers, P. M., Das, D., Degrip, W. J., Bowmaker, J. K. and Hunt, D. M. (1998) The molecular basis for UV vision in birds: spectral characteristics, cDNA sequence and retinal localization of the UV-sensitive visual pigment of the budgerigar (Melopsittacus undulatus). Biochemical Journal 15, 541-547.
107.Reichel, M. B., Ali, R. R., Thrasher, A. J., Hunt, D. M., Bhattacharya, S. S. and Baker, D. (1998) Immune responses limit adenovirally-mediated gene expression in the adult mouse eye. Gene Therapy 5, 1038-1046.
108.Ali, R. R., Reichel, M. B., de Alwis, M., Kanuga, N., Kinnon, C., Levinsky, R. J., Hunt, D. M., Bhattacharya, S. S. and Thrasher, A. J. (1998) Adeno-associated virus gene transfer to mouse retina. Human Gene Therapy 9, 81-86.
109.Hunt, D. M., Dulai, K. S., Cowing, J. A., Julliot, C., Mollon, J. D., Bowmaker, J. K., Li, W-H. and Hewett-Emmett, D. (1998) Molecular evolution of trichromacy in primates. Vision Research 38, 3299-3306.
110.Silveira, L. C. L., Lee, B. B., Yamada, E. S., Kremers, J. and Hunt, D. M. (1998) Post-receptoral mechanisms of colour vision in New World primates. Vision Research 38, 3329-3337
111.Fasick, J. L., Cronin, T. W., Hunt, D. M. and Robinson, P. R. (1998) The visual pigments of the bottlenose dolphin (Tursiops truncatus). Visual Neuroscience 15, 643-652.
112.Reichel, M.B., Kelsell, R.E., Fan, J., Gregory, C.Y., Evans, K., Moore, A.T., Hunt, D.M., Fitzke, F.W. and Bird, A.C. (1998) Phenotype of a British North Carolina macular dystrophy family linked to chromosome 6q. Brit. J. Ophthalmol. 82, 1162-1168.
113.Kelsell, R.E., Evans, K., Gregory, C.Y., Jay, M.R., Holder, G. E., Moore, A.T., Bird, A.C. and Hunt, D.M. (1998) Localisation of a gene (CORD7) for dominant cone-rod dystrophy to chromosome 6q. American Journal of Human Genetics 63, 274-279.
114.Gehrig, A., Felbor, U., Kelsell, R. E., Hunt, D. M., Maumenee, I. H. and Weber, B. H. F. (1998) Assessment of interphotoreceptor matrix proteoglycan-1 (IMPG1) gene localized to 6q13-q15 in autosomal dominant Stargardt-like disease (ADSTGD), progressive bifocal chorioretinal atrophy (PBCRA), and North Carolina macular dystrophy (MCDR1). Journal of Medical Genetics 35, 641-645.
115.Kelsell, R.E., Yang, R-B., Gregory-Evans, K., Payne, A. M., Kaplan, J., Perrault, I., Garbers, D. L., Bird, A.C., Moore, A.T. and Hunt, D.M. (1998) Mutations in the retinal guanylate cyclase (RETGC-1) gene in dominant cone-rod dystrophy. Human Molecular Genetics 7, 1179-1184.
116.Douglas, R. H., Partridge, J. C., Dulai, K. S., Hunt, D. M, Mullineaux, C., Tauber, A. Y. and Hynninen, P. H. (1998) Dragon fish see using chlorophyll. Nature 393, 423-424.
117.David-Gray, Z. K., Gurnell, J. and Hunt, D. M. (1998) DNA fingerprinting reveals high levels of genetic diversity within British populations of the introduced non-native grey squirrel, Sciurus carolinensis. Journal of Zoology 246, 443-445.
118.Bellingham, J., Morris, A. G. and Hunt, D. M. (1998) The rhodopsin gene of the cuttlefish, Sepia officinalis: cDNA sequence, gene structure and spectral tuning. Journal of Experimental Biology 201, 2299-2306.
119.Shyue, S-K., Boissinot, S., Schneider, H., Sampaio, I., Schneider, M. P., Abee, C. R., Williams, L., Hewett-Emmett, D., Sperling, H. G., Cowing, J. A., Dulai, K. S., Hunt, D. M. and Li, W-H. (1998) Molecular genetics of spectral tuning in New World monkey color vision. Journal of Molecular Evolution 46, 697-702.
120.Ali, R. R., Reichel, M. B., Kanuga, N., Clarke, A. R., Luthert, P. J., Bhattacharya, S. S. and Hunt, D. M. (1998) Retinal degeneration is delayed in p53-deficient rds mice. Current Eye Research 17, 917-923.
121.Perrault, I., Rozet, J-M., Gerber, S., Kelsell, R.E., Souied, E., Cabot, A., Hunt, D.M., Munnich, A. and Kaplan, J. (1998) A retGC-1 mutation in autosomal dominant cone-rod dystrophy. American Journal of Human Genetics 63, 651-654.
122.Reichel, M. B., Ali, R. R., Thrasher, A. J., Hunt, D. M., Bhattacharya, S. S. and Baker, D. (1998) Immune responses limit adenovirally-mediated gene expression in the adult mouse eye. Gene Therapy 5, 1038-1046..
123.Halford, S., Dulai, K. S., Fitzgibbon, J. and Hunt, D. M. (1998) Isolation and chromosomal localisation of two human CDP-diacylglycerol synthase (CDS) genes. Genomics 54, 140-144.
124.Silveira, L. C. L., Lee, B. B., Yamada, E. S., Kremers, J. and Hunt, D. M. (1998) Post-receptoral mechanisms of colour vision in new world primates. Vision Research 38, 3329-3337.
125.Ali, R. R., Reichel, M. B., Baker, D., Byrnes, A. P., Kanuga, N., Hunt, D. M. and Bhattacharya, S. S. (1998) Co-injection of adenovirus expressing CTLA4-Ig prolongs adenovirally-mediated LacZ reporter gene expression in the mouse retina. Gene Therapy 11, 1561-1565.
126.Silveira, L. C. L., Lee, B. B., Yamada, E. S., Kremers, J., Hunt, D. M., Martin, P. R. and Gomes, F. L. (1999) Ganglion cells of a short wavelength sensitive cone pathway in New World monkeys: morphology and physiology. Visual Neuroscience 16, 333-343.
127.Douglas, R. H., Partridge, J. C., Dulai, K. S., Hunt, D. M., Mullineaux, C. W. and Hynninen, P. H. (1999) Enhanced retinal longwave sensitivity using a chlorophyll-derived photosensitiser in Malacosteus niger, a deep-sea dragon fish with far-red bioluminescence. Vision Research 39, 2817-2832.
128.Das, D., Wilkie, S. E., Hunt, D. M. and Bowmaker, J. K. (1999) Visual pigments and oil droplets in the retina of a passerine bird, the canary Serinus canaria: microspectrophotometry and opsin sequences. Vision Research 39, 2801-2815.
129.Dulai, K. S., von Dornum, M., Mollon, J. D. and Hunt, D. M. (1999) The evolution of trichromatic colour vision by opsin gene duplication in New World and Old World primates. Genome Research 9, 629-638.
130.David-Gray, Z. K., Gurnell, J. and Hunt, D. M. (1999) Estimating relatedness in a population of grey squirrels, Sciurus carolinensis. Acta Theriologica 44, 3.
131.Tucker, C. L., Woodcock, S. C., Kelsell, R. E., Ramamurthy, V., Hunt, D. M. and Hurley, J. B. (1999) Biochemical analysis of a dimerization domain mutation in RetGC-1 associated with dominant cone-rod dystrophy. Proceeding of the National Academy of Science, USA, 96, 9039-9044.
132.Small, K. W., Yelchits, S., Udar, N., Klein, R., Garcia, C., Gallardo, G., Puech, B., Puech, V., Saperstein, D., Lin, J., Flaxel, C., Weber, B., Sauer, C., Kelsell, R. E., Hunt, D. M., Evans, K., Lennon, F. and Pericak-Vance, M. (1999) North Carolina macular dystrophy (MCDR1) locus: a fine resolution genetic map and haplotype analysis. Molecular Vision 5, 38.
133.Gregory-Evans, K., Kelsell, R.E., Gregory-Evans, C.Y., Downes, S., Fitzke, F. W., Holder, G. E., Simunovic, M., Mollon, J. D., Taylor, R., Hunt, D.M., Bird, A.C. and Moore, A.T. (2000) Autosomal dominant cone-rod retinal dystrophy (CORD6) from heterozygous mutation of GUCY2D, which encodes retinal guanylate cyclase. Ophthalmology 107, 55-61.
134.Sivagnanasundaram, S., Morris, A. G, Gaitonde, E. J., McKenna, P. J., Mollon, J. D. and Hunt, D. M. (2000) A cluster of single nucleotide polymorphisms in the 5'-leader of the human dopamine D3 receptor gene (DRD3) and their relationship with schizophrenia. Neuroscience Letters 279, 13-16.
135.Halford, S.,Spencer, P., Greenwood, J., Winton, H., Hunt, D. M. and Adamson, P. (2000) Assignment of claudin-1 (CLDN1) to human chromosome 3q28-29 with somatic cell hybrids. Cytogenetics and Cell Genetics 88, 217.
136.Ali, R. R., Sarra, G. M., Stephens, C., de Alwis, M., Bainbridge, J. B. L., Munro, P. M., Fauser, S., Reichel, M. B., Kinnon, C., Hunt, D. M., Bhattacharya, S. S. and Thrasher, A. J. (2000) Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy. Nature Genetics 25, 306-310.
137.Wilkie, S. E., Robinson, P. R., Cronin, T. W., Popoolasundarum, S., Bowmaker, J. K. and Hunt, D. M. (2000) Spectral tuning of avian violet- and ultraviolet-sensitive visual pigments. Biochemistry 39, 7895-7901.
138.Lee, B. B., Silveira, L. C. L., Yamada, E. S., Hunt, D. M., Kremers, J., Martin, P. R., Troy, J. B. and da Silva-Filho, M. (2000) Visual responses of ganglion cells of a New-World primate, the capuchin monkey, Cebus apella. Journal of Physiology 528, 573-590.
139.Wilkie, S. E.,Newbold, R. J., Raux, E., Walker, C. E., Stinton, I., Visvanathan, R., Hurley, J. B., Bhattacharya, S. S., Warren, M. J. and Hunt, D. M. (2000) Functional characterisation of missense mutations at codon 838 in retinal guanylate cyclase correlates with disease severity in patients with autosomal dominant cone-rod dystrophy. Human Molecular Genetics 9, 3065-3073.
140.Newbold, R. J., Deery, E., Walker, C. E.,Wilkie, S. E., Srinivasan, N., Hunt, D. M., Bhattacharya, S. S. and Warren, M. J. (2001) A cone-rod dystrophy caused by the destabilisation of human GCAP1 by a proline to leucine mutation. Human Molecular Genetics 10, 47-54.
141.Downes, S. M., Payne, A. M., Kelsell, R. E., Fitzke, F. W., Holder, G. E., Hunt, D. M., Moore, A. T., and Bird, A. C. (2001) Autosomal dominant cone-rod dystrophy with mutations in the guanylate cyclase 2D gene encoding retinal guanylate cyclase-1. Archives of Ophthalmology 119, 1667-1673.
142.Halford, S., Bellingham, J., Freedman, M. S., Inglis, S. L., Poopalasundaram, S., Foster, R and Hunt, D. M. (2001) Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43. Genomics 72, 203-208.
143.Ramamurthy, V., Tucker, C., Wilkie, S. E., Daggett, V., Hunt, D. M. and Hurley, J. B. (2001) Interactions within the coiled-coil domain of RetGC-1 guanylyl cyclase are optimized for regulation rather than for high affinity. Journal of Biological Chemistry 276, 26218-26229.
144.Payne, A. M., Morris, A. G., Downes, S. M., Bird, A. C., Moore, A. T., Bhattacharya, S. S. and Hunt, D. M. (2001) Clustering of mutations in the retinal guanylate cyclase (GUCY2D) gene in patients with dominant cone-rod macular dystrophies. Journal of Medical Genetics 38, 611-614.
145.Hunt, D. M., Dulai, K. S., Cottrill, P. B., Partridge, J. C. and Bowmaker, J. K. (2001) The molecular basis for spectral tuning of rod visual pigments in deep sea fish. Journal of Experimental Biology 204, 3333-3344.
146.Vithana, E. N., Abu-Safieh, L., Allen, M. J., Carey, A., Papaioannou, M., Chakarova, C., Al-Maghtheh, M., Ebenezer, N. D., Willis, C., Moore, A. T., Bird, A. C., Hunt, D. M. and Bhattacharya, S. S. (2001) A human homologue of yeast pre mRNA-splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4. Molecular Cell 8, 375-381.
147.Wilkie, S. E., Li, Y., Deery, E. C., Newbold, R. J., Garibaldi, D., Bateman, B., Zhang, H., Lin, W., Bhattacharya, S. S., Warren, M. J., Hunt, D. M. and Zhang, K. (2001) Identification and functional consequences of a new mutation (E155G) in GCAP1 causing autosomal dominant cone dystrophy. American Journal of Human Genetics 69, 671-680.
148.Halford, S., Bellingham, J., Ocaka, L., Fox, M., Johnson, S., Foster, R.G. and Hunt, D.M. (2001) Assignment of panopsin (OPN3) to human chromosome band 1q44 by in situ hybridisation and somatic cell hybrids. Cytogenetics and Cell Genetics 95, 234-235.
149.Chakarova, C. F., Hims, M. M., Bolz, H., Abu-Safieh, L., Patel, R. J., Papaioannou, M. G., Inglehearn, C. F, Keen, T. J., Willis, C., Moore, A. T., Rosenberg, T., Webster, A. R., Bird, A. C., Gal, A., Hunt, D., Vithana, E. M. and Bhattacharya, S. S. (2002) Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa. Human Molecular Genetics 11, 87-92.
150.Cowing, J. A., Poopalasundarum, S., Wilkie, S. E., Robinson, P. R., Bowmaker, J. K. and Hunt, D. M. (2002) Spectral tuning and evolution of short wave-sensitive cone pigments in cottoid fish from Lake Baikal. Biochemistry 41, 6019-6025.
151.Wilkie, S. E., Stinton, I., Cottrill, P., Derry, E. C., Newbold, R. J., Warren, M. J., Bhattacharya, S. S. and Hunt, D. M. (2002) Characterisation of two genes for guanylate cyclase activator protein (GCAP1 and GCAP2) in the Japanese Pufferfish, Fugu rubripes. Biochimica et Biophysica Acta 1577, 73-80.
152.Ayton, A., Morris, A. G., Tyson, P. J., Hunt, D., Mortimer, A. M. and Cottrell, D. (2002) Early Development and Unstable Genes in Schizophrenia: Preliminary Results. European Psychiatry 17, 332-338.
153.Halford, S., Inglis, S., Gwiliam, R., Spencer, P., Mohammed, M., Ebenezer, N. and Hunt, D. M. (2002) Genomic organisation of human CDS2 and evaluation as a candidate gene for corneal hereditary endothelial dystrophy 2 (CHED2) on chromosome 20p13. Experimental Eye Research 75, 619-623.
154.Cowing, J. A., Poopalasundaram, S., Wilkie, S. E., Robinson, P. R., Bowmaker, J. K. and Hunt, D. M. (2002) The molecular mechanism for the spectral shifts between vertebrate ultraviolet- and violet-sensitive cone visual pigments. Biochemical Journal 367, 129-135.
155.Aligianis, I. A., Forshew, T., Johnson, S., Michaelides, M., Johnson, C. A., Trembath, R. C., Hunt, D. M., Moore, A. T. and Maher, E. R. (2002) Mapping of a novel locus for achromatopsia (ACHM4) to 1p and identification of a germline mutation in the α subunit of cone transducin (GNAT2). Journal of Medical Genetics 39, 656-600.
156.Deery, E. C., Vithana, E. N., Newbold, R. J., Gallon, V. A., Bhattacharya, S. S., Warren, M. J., Hunt, D. M. and Wilkie, S. E. (2002) Disease mechanism for retinitis pigmentosa (RP11) caused by mutations in the splicing gene PRPF31. Human Molecular Genetics 11, 3209-3219.
157.Newbold, R. J., Deery, E. C., Payne, A. M., Wilkie, S. E., Hunt, D. M. and Warren, M. J. (2002) Guanylate cyclase activating proteins, guanylate cyclase and disease. Adv Exp Med Biol 514, 411-38.
158.Michaelides, M., Johnson, S., Poulson, A., Bradshaw, K., Bellman, C., Hunt, D. M. and Moore, A. T. (2003) An autosomal dominant bull’s eye macular dystrophy (MCDR2) that maps to the short arm of chromosome 4. Investigative Ophthalmology and Visual Science 44, 1657-62.

159.Michaelides, M., Johnson, S., Tekriwal, A. K., Woodruff, G., Holder, G., Bellmann, C., Kinning, E., Trembath, R. C., Hunt, D. M. and Moore, A. T. (2003) An early onset autosomal dominant macular dystrophy (MCDR3) resembling North Carolina macular dystrophy maps to chromosome 5. Investigative Ophthalmology and Visual Science 44, 2178-2183.
160.Johnson, S., Halford, S., Morris, A. G., Patel, R., Wilkie, S. E., Hardcastle, A. J., Moore, A. T., Zhang, K. and Hunt, D. M. (2003) Genomic organisation and alternate splicing of human RIM1, a gene implicated in autosomal dominant cone-rod dystrophy (CORD7). Genomics 81, 304-314.
161.Francis, P. J., Johnson, S., Edmunds, B., Kelsell, R., Sheridan, E., Garrett, C., Hunt, D.M. and Moore, A. T. (2003) Genetic linkage analysis of a novel syndrome comprising North Carolina-like macular dystrophy and progressive sensorineural hearing loss. British Journal of Ophthalmology 87, 893-898.
162.Michaelides, M., Aligianis, I. A., Holder, G. E., Simunovic, M., Mollon, J. D., Maher, E. R., Hunt, D. M. and Moore, A. T. (2003) Cone dystrophy phenotype associated with a frameshift mutation (M280fsX291) in the α-subunit of cone-specific transducin (GNAT2). British Journal of Ophthalmology 87, 1317-1320.
163.Vithana, E. N., Abu-Safieh, L., Pelosini, L., Winchester, E., Hornan, D., Bird, A. C., Hunt, D. M., Bustin, S. A. and Bhattacharya, S. S. (2003) Expression of PRPF31 mRNA in patients with autosomal dominant retinitis pigmentosa: a molecular clue for incomplete penetrance? Investigative Ophthalmology and Visual Science 44, 4204-4209.
164.Collin, S. P., Knight, M. A., Davies, W. L., Potter, I. C., Hunt, D. M. and Trezise, A. E. O. (2003) Ancient colour vision: multiple opsin genes in the ancestral vertebrates. Current Biology 13, R864-R865.
165.Hunt, D. M., Arrese, C. A., von Dornum, M., Rodger, J., Oddy, A., Cowing, J. A., Ager, E. I., Bowmaker, J. K., Beazley, L. D. and Shand, J. (2003) The rod opsin pigments from two marsupial species, the South American bare-tailed woolly opossum and the Australian fat-tailed dunnart. Gene 323, 157-162.
166.Johnson, S., Michaelides, M., Aligianis, I. A., Ainsworth, J. R., Maher, E. R., Mollon, J. D., Moore, A. T. and Hunt, D. M. (2004) Achromatopsia caused by novel mutations in both CNGA3 and CNGB3. Journal of Medical Genetics 41, e21.
167.Michaelides, M., Holder, G. E., Bradshaw, K., Hunt, D. M., Mollon, J. D. and Moore, A. T. (2004) Oligocone trichromacy: a rare and unusual cone dysfunction syndrome. British Journal of Ophthalmology 88, 497-500.
168.Michaelides, M., Aligianis, I. A., Johnson, S., Good, P., Ainsworth, J. R., Mollon, J. D., Maher, E. R., Moore, A. T. and Hunt, D. M. (2004) Progressive cone dystrophy associated with mutation in CNGB3. Investigative Ophthalmology and Visual Science 45, 1975-1982.
169.Michaelides, M., Bloch-Zupan, A., Holder, G. E., Hunt, D. M. and Moore, A. T. (2004) An autosomal recessive cone-rod dystrophy associated with amelogenesis imperfecta. Journal of Medical Genetics 41, 468-473.
170.Parry, J. W. L., Poopalasundaram, S., Bowmaker, J. K. and Hunt, D. M. (2004) A novel amino acid substitution is responsible for spectral tuning in a rodent violet-sensitive visual pigment. Biochemistry 43, 8014-8020.
171.Gallon, V. A, Wilkie, S. E., Deery, E. C., Newbold, R. J., Sohocki, M. M., Bhattacharya, S. S., Hunt, D. M. and Warren, M. J. (2004) Purification, characterisation and intracellular localisation of aryl hydrocarbon interacting protein-like 1 (AIPL1) and effects of mutations associated with inherited retinal dystrophies. Biochimca et Biophysica Acta 1690, 141-149.
172.Michaelides, M., Simunovic, Johnson, S., M., Halford, S., Bradshaw, K., Mollon, J. D., Moore A. T. and Hunt, D. M. (2005) Blue cone monochromatism: a phenotype and genotype assessment with evidence of progressive loss of cone function in older individuals. Eye 19, 2-10.
173.Ocaka, L., Spalluto, C., Wilson, D. I., Hunt, D. M. and Halford, S. (2005) Chromosomal localisation, genomic organisation and evolution of the genes encoding phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3. Cytogenetic and Genome Research 108, 293-302.
174.Michaelides, M., Holder, G. E., Hunt, D. M., Bird, A. C., Fitzke, F. W. and Moore, A. T. (2005) A detailed study of the phenotype of an autosomal dominant cone-rod dystrophy (CORD7) associated with mutation in the gene for RIM1. British Journal of Ophthalmology 89, 198-206.
175.Michaelides, M., Holder, G. E., Webster, A. R., Hunt, D. M., Bird, A. C., Fitzke, F. W., Mollon, J. D. and Moore, A. T. (2005) A detailed phenotypic study of cone dystrophy with supernormal rod ERG. British Journal of Ophthalmology 89, 332-339.
176.Arrese, C. A., Oddy, A. Y., Runham, P. B., Hart, N. S., Shand, J., Hunt, D. M. and Beazley, L. D. (2005) Cone topography and spectral sensitivity in two potentially trichromatic marsupials, the quokka (Setonix brachyurus) and quenda (Isoodon obesulus). Proceedings of the Royal Society 272, 791-796.
177.Michaelides, M., Johnson, S., Simunovic, M., Halford, S., Bradshaw, K., Mollon, J. D., Moore A. T. and Hunt, D. M. (2005) X-linked cone dystrophy with myopia and protanopia. Ophthalmology 112, 1448-1454.
178.Inglis-Broadgate, S. L., Ocaka, L., Banerjee, R., Gaasenbeek, M., Chapple, J. P., Cheetham, M., Clark, B. J., Hunt, D. M. and Halford, S. (2005) Isolation and characterisation of murine Cds (CDP-diacylglycerol synthase) 1 and 2. Gene 356, 19-31.
179.Michaelides, M., Holder, G. E., Bradshaw, K., Hunt, D. M. and Moore, A. T. (2005) Cone-rod dystrophy, intrafamilial variability and incomplete penetrance associated with the R172W mutation in the Peripherin/RDS gene. Ophthalmology 112, 1592-1598.
180.Pointer, M. A., Cheng, C-H. C., Bowmaker, J. K., Jeffery, G., Parry, J. W. L., Cowing, J. A. and Hunt, D. M. (2005) Adaptations to an extreme environment: the visual system of Antarctic notothenioid fish. Journal of Experimental Biology 208, 2363-2376.
181.Michaelides, M., Wilkie, S. E., Jenkins, S., Holder, G. E., Hunt, D. M., Moore, A. T. and Webster, A. R. (2005) Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy. Ophthalmology 112, 1442-1447.
182.Carleton, K. L., Parry, J. W. L., Bowmaker, J. K., Hunt, D. M. and Seehausen, O. (2005) Colour vision and speciation in Lake Victoria cichlids from the genus Pundamilia. Molecular Ecology 14, 4341-4353.
183.Parry, J. W. L., Carleton, K. L., Spady, T., Carboo, A., Hunt, D. M. and Bowmaker, J. K. (2005) Mix and match color vision: tuning spectral sensitivity by differential opsin gene expression in Lake Malawi cichlids. Current Biology 15, 1734-1739.
184.Arora, A., Minogue, P. J., Liu, X., Reddy, M. A., Ainsworth, R., Bhattacharya, S. S., Webster, A. R., Hunt, D. M., Ebihara, L., Moore, A. T., Beyer, E. C. and Berthoud, V. M. (2006) A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract. Journal of Medical Genetics 43, e2.
185.Wilkie, S. E., Morris, K. J., Bhattacharya, S. S., Warren, M. J. and Hunt, D. M. (2006) A study of the nuclear trafficking of the splicing factor protein PRPF31 linked to autosomal dominant retinitis pigmentosa (ADRP). Biochimica Biophysica Acta 1762, 304-311.
186.Carvalho, L., Cowing, J. A., Wilkie, S. E., Bowmaker, J. K. and Hunt, D. M. (2006) Shortwave visual sensitivity in tree and flying squirrels reflects changes in life style. Current Biology 16, R81-83.
187.Nickle, B., Wilkie, S. E., Cowing, J. A., Hunt, D. M. and Robinson, P. R. (2006) Vertebrate opsins belonging to different classes vary in constitutively active properties resulting from salt-bridge mutations. Biochemistry 45, 7307-7313.
188.Arrese, C. A., Beazley, L. D., Ferguson, M. C., Oddy, A. and Hunt, D. M. (2006) Spectral tuning of the long wavelength-sensitive cone pigment in four Australian marsupials. Gene 381, 13-17.
189.Spady, T. C., Parry, J. W. L., Robinson, P. R., Hunt, D. M., Bowmaker, J. K. and Carleton, K. L. (2006) Evolution of the cichlid visual palette through ontogenetic subfunctionalization of the opsin gene arrays. Molecular Biology and Evolution 23, 1538-1547.
190.Wu, H., Cowing, J. A., Michaelides, M., Wilkie, S. E., Jeffery, G., Jenkins, S. A., Nazari, M. M. Y., Mester, V., Bird, A. C., Robson, A. G., Holder, G. E., Moore, A. T., Hunt, D. M. and Webster, A. R. (2006) Mutation in the gene KCNV2, encoding a voltage-gated potassium channel subunit cause “cone dystrophy with a supernormal rod electroretinogram” in humans. American Journal of Human Genetics 79, 574-579.
191.Davies, W. L., Carvalho, L. S., Cowing, J. A., Beazley, L. D., Hunt, D. M. and Arrese, C. A. (2007) Visual pigments of the platypus: a novel route to mammalian colour vision. Current Biology 17, R161-163.
192.Sisodiya, S. M., Thompson, P. J., Need, A., Harris, S. E., Weale, M. E., Wilkie, S. E., Michaelides, M., Free, S. L., Walley, N., Gumbs, C., Gerrelli, D., Ruddle, P., Whalley, L. J., Starr, J. M., Hunt, D. M., Goldstein, D. B., Deary, I. J., and Moore, A. T. (2007) Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation. Journal of Medical Genetics 44, 373-380.
193.Pointer, M. A., Carvalho, L. S., Cowing, J. A., Bowmaker, J. K. and Hunt, D. M. (2007) The visual pigments of the deep-sea pearleye, Scopelarchus analis. Journal of Experimental Biology 210, 2829-2835.
194.Davies, W. L., Cowing, J. A., Carvahlo, L. S., Potter, I. C. Trezise, A. E., Hunt, D. M. and Collin, S. P. (2007) Functional characterisation and regulation of visual pigment gene expression in an anadromous lamprey. FASEB Journal 21, 2713-2724.
195.Carvalho, L. S., Cowing, J. A., Wilkie, S. E., Bowmaker, J. K. and Hunt, D. M. (2007) The molecular evolution of avian ultraviolet- and violet-sensitive visual pigments. Molecular Biology and Evolution 24, 1843-1852.
196.Davies, W. L., Carvalho, L. S. and Hunt, D. M. (2007) SPLICE: a technique for generating in vitro spliced coding sequences from genomic DNA. Biotechniques 43, 785-789.
197.Bowmaker, J. K., Semo M., Hunt, D. M. and Jeffrey, G. (2008) Eel visual pigments revisited: The fate of retinal cones during metamorphosis Visual Neuroscience 25, 249-255.
198.Audo, I., Michaelides, M., Hawlina, M., Robson, A. G., Sandbach, J., Neveu, M. M., Hogg, C. R., Hunt, D. M., Moore, A. T., Bird, A. C., Webster, A. R. and Holder, G. E. (2008) Phenotypic variation in enhanced S-cone syndrome. Investigative Ophthalmology and Visual Science 49, 2082-2093.
199.Arora, A., Minogue, P. J., Liu, X., Addison, P. K., Russel-Eggitt, I., Webster, A. R., Hunt, D. M., Ebihara, L., Beyer, E. C., Berthoud, V. M. and Moore, A. T. (2008) A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts. Journal of Medical Genetics 45, 155-160.
200.Wilkie, S. E., Vaclavik, V., Wu, H., Bujakowska, K., Chakarova, C. F., Bhattacharya, S. S., Warren, M. J. and Hunt, D. M. (2008) Dual disease mechanism for retinitis pigmentosa (RP11) caused by missense mutations in the splicing factor gene PRPF31. Molecular Vision 14, 683-690.
201.Shand, S., Davies, W. L., Thomas, N., Balmer, L., Cowing, J. A., Pointer, M. A., Carvalho, L. S., Trezise, A. E., Collin, S. P., Beazley, L. D. and Hunt, D. M. (2008) The influence of ontogeny and light environment on the expression of visual pigment opsins in the retina of the black bream, Acanthopagrus butcheri. Journal of Experimental Biology 211, 1495-1503.
202.Bowmaker, J. K., Semo, M., Hunt, D. M. and Jeffery, G. (2008) Eel visual pigments revisited: the fate of cones during metamorphosis. Visual Neuroscience 25, 249-255.
203.Cowing, J. A., Arrese, C. A., Davies, W. L., Beazley, L. and Hunt, D. M. (2008) Cone visual pigments in two marsupial species, the fat-tailed dunnart, Sminthopsis crassicaudata, and the honey possum, Tarsipes rostratus. Proceeding of the Royal Society 275, 1491-1499.
204.Brindley, A. A., Pickersgill, R. W., Partridge, J. C., Dunstan, D. J., Hunt, D. M. and Warren, M. J. (2008) Enzyme sequence and its relationship to hyperbaric stability of artificial and natural fish lactate dehydrogenases. PLoS ONE 3, e2042.
205.Moradi, P., Mackay, D., Hunt, D. M. and Moore, A. T. (2008) Focus on Molecules: Retinol Dehydrogenase 12 (RDH12). Experimental Eye Research 87, 160-161.
206.Yang, Z., Chen, Y., Lillo, C., Chien, J., Yu, Z., Michaelides, M., Klein, M., Howes, K. A., Li, Y., Kaminoh, Y., Chen, H., Zhao, C., Chen, Y., Al-Sheikh, Y. T., Karan, G., Corbeil, D., Escher, P., Kamaya, S., Li, C., Johnson, S., Frederick, J. M., Zhao, Y., Wang, C., Cameron, D. J., Huttner, W. B., Schorderet, D. F., Munier, F. L., Moore, A. T., Birch, D. G., Baehr, W., Hunt, D. M., Williams, D. S. and Zhang, K. (2008) Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. Journal of Clinical Investigation 118, 2908-2916.
207.Yang, Z., Tong, Z., Chorich, L. J., Pearson, E., Yang, X., Moore, A., Hunt, D. M. and Zhang, K. (2008) Clinical characterization and genetic mapping of North Carolina macular dystrophy. Vision Research 48, 470-477.
208.Davies, W. L., Carvalho, L. S., Tay, B. H., Brenner, S., Hunt, D. M. and Venkatesh, B. (2009) Into the blue: gene duplication and loss underlie colour vision adaptations in a deep-sea chimaera, the elephant shark Callorhinchus milii. Genome Research 9, 415-426.
209.Metlapally, R., Michaelides, M., Bulusu, A., Li, Y-J., Schwartz, M., Rosenberg, T., Hunt, D. M., Moore, A. T., Zuchner, S., Bowes Rickman, C. and Young, T. L. (2009) Evaluation of the X-Linked High Grade Myopia Locus (MYP1) with cone dysfunction and color vision deficiencies. Investigative Ophthalmology and Visual Science 50, 1552-1158.
210.Hunt, D. M., Chan, J., Carvalho, L. S., Hokoc, J. N., Ferguson, M. C., Arrese, C. A. and Beazley, L. D. (2009) Visual pigments in two species of South American marsupials. Gene 433, 50-55.
211.Davies, W. L., Collin, S. P. and Hunt, D. M. (2009) Adaptive gene loss reflects differences in visual ecology in ancient vertebrates. Molecular Biology and Evolution 26, 1803-1809.
212.Davies, W. L., Cowing, J. A., Bowmaker, J. K., Carvalho, L. S., Gower, D. J. and Hunt, D. M. (2009) Shedding light on serpent sight: the visual pigments of henophidian snakes. Journal of Neuroscience 29, 7519-7525.
213.Minogue, P. J., Tong, J-J., Arora, A., Russell-Eggitt, I., Hunt, D. M., Moore, A. T., Ebihara, L., Beyer, E. C. and Berthoud, V. M. (2009) A mutant connexin50 with enhanced hemichannel function contributes leads to cell death. Investigative Ophthalmology and Visual Science 50, 5837-45.
214.Cottrill, P. B., Davies, W. L., Bowmaker, J. K., Hunt, D. M. and Jeffery, G. (2009) Developmental dynamics of cone photoreceptors in the eel. BMC Developmental Biology 9, 71.
215.Robson, A. G., Webster, A. R., Michaelides, M., Downes, S. M., Cowing, J. A., Hunt, D. M., Moore, A. T. and Holder, G. E. (2010) “Cone dystrophy with supernormal rod electroretinogram”: a comprehensive genotype/phenotype study including fundus autofluorescence and extensive electrophysiology. Retina 30, 51-62.
216.Palacios, A. G., Bozinovic, F., Vielma, A., Arrese, C. A., Hunt, D. M. and Peichl, L. (2010) Retinal photoreceptor arrangement, SWS1 and LWS opsin sequence, and electroretinography in the South American Marsupial Thylamys elegans (Waterhouse, 1839). Journal of Comparative Neurology 518, 1589-602.
217.Michaelides, M., Gaillard, M-C., Escher, P., Tiab, L., Bedell, M., Borruat, F-X., Barthelmes, D., Carmona, R., Zhang, K., White, E., McClements, M., Robson, A. G., Holder, G. E., Bradshaw, K., Hunt, D. M., Webster, A. R., Moore, A. T., Schorderet, D. F. and Munier, F. L. (2010) The PROM1 mutation p.R373C causes an autosomal dominant bull’s eye maculopathy associated with rod, rod-cone, and macular dystrophy. Investigative Ophthalmology and Visual Science 51, 4771-4780.
218.Mohun S. M., Davies W. L., Bowmaker J. K., Pisani. D., Himstedt, W., Gower, D., Hunt D.M. and Wilkinson, M. (2010) Identification and characterization of visual pigments in caecilians, a group of limb-less amphibians with rudimentary eyes from the Order Gymnophiona. Journal of Experimental Biology 213, 3586-3592.
219.Arrigoni, F. I., Matarin, M., Thompson, P. J., Michaelides, M., McClements, M. E., Redmond, E., Clarke, L., Ellins, E., Mohamed, S., Pavord, I., Hunt, D. M., Klein, N., Moore, A. T., Halcox, J. and Sisodiya, S. M. (2011) Extended extraocular phenotype of PROM1 mutation in kindreds with known autosomal dominant macular dystrophy. European Journal of Human Genetics 19, 131-137.
220.Carvalho, L.S., Knott, B., Berg, M. L., Bennett, A. T. D. and Hunt, D. M. (2011) Ultraviolet-sensitive vision in long-lived birds. Proceedings of the Royal Society B 278, 107-114.
221.Buch, P. K., Mihelec, M., Cottrill, P., Wilkie, S. E., Pearson, R. A., Duran, Y., West, E. L., Michaelides, M., Ali, R. R. and Hunt, D. M. (2011) Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/guca1a gene. PLoS One 6: e18089.
222.Hogg, C., Neveu, M., Stokkan, K-A., Folkow, L., Cottrill, P., Douglas, R., Hunt, D. M., Jeffery, G. (2011) Arctic reindeer extend their visual range into the ultraviolet. Journal of Experimental Biology 214, 2014-2019.
223.Carvalho, L. S., Davies, W. L., Robinson, P. R. and Hunt, D. M. (2012) Spectral tuning and evolution of primate short wavelength-sensitive visual pigments. Proceedings of the Royal Society B 279, 387-393.
224.Davies, W. L., Wilkie, S.. E., Cowing, J. A., Hankins, M. W., and Hunt, D. M. (2012) Anion sensitivity and spectral tuning of middle- and long-wavelength-sensitive (MWS/LWS) visual pigments. Cellular and Molecular Life Sciences 69, 2455-2464.
225.Davies, W. I. L., Tay, B-H., Zheng, L., Danks, J. A., Brenner, S., Foster, R. G., Collin, S. P., Hankins, M. W., Venkatesh, B., and Hunt, D. M. (2012) Evolution and functional characterisation of melanopsins in a deep-sea chimaera (elephant shark, Callorhinchus milii). PLoS One 7, e51276.
226.Theiss, S. M., Davies, W. I. L., Collin, S. P. and Hunt, D. M., and Hart, N. S. (2012) Cone monochromacy and visual pigment spectral tuning in wobbegong sharks. Biology Letters 8, 1019-1022.
227.Smith, K., Willie, S. E., Tebbs-Warner, J. T., Jarvis, B. J., Gallasch, L., Stocker, M. and Hunt, D. M. (2012) Functional analysis of missense mutations in Kv8.2 causing cone dystrophy with supernormal rod electroretinogram. Journal of Biological Chemistry 287, 43972-43983.
228.McClements, M., Davies, W. L., Carroll, J., Michaelides, M., Neitz, M., Mollon, J. D., MacLaren, R., Moore, A. T. and Hunt, D. M. (2013) X-linked cone dystrophy and colour vision deficiency arising from a missense mutation in a hybrid L/M cone opsin gene. Vision Research 80, 41-50.
229.Carroll, C., Dubra, A., Gardner, J. C., Mizrahi-Meissonnier, L., Cooper, R. F., Dubis, A. M., Nordgren, R., Genead, M., Connor, T. B., Jr., Stepien, K. E., Sharon, D., Hunt, D. M., Banin, E., Hardcastle, A. J., Moore, A. T., Williams, D. R., Fishman, G., Neitz, J., Neitz, M., and Michaelides, M. (2012) The Effect of Cone Opsin Mutations on Retinal Structure and the Integrity of the Photoreceptor Mosaic. Investigative Ophthalmology and Visual Research 53, 8006-8015.
230.Kempster, R. M., Hunt, D. M., Human, B. A., Egeberg, C. A. and Collin, S. P. (2013) First record of the mandarin dogfish Cirrhigaleus barbifer (Chondrichthyes: Squalidae) from Western Australia. Marine Biodiversitry Records 6, e25.
231.McClements, M., Davies, W. I, L., Carroll, J., Michaelides, M., Young, T., Neitz, M., MacLaren, R., Moore, A. T., and Hunt, D. M. (2013) Variations in opsin coding sequences disrupt opsin stability and cause X-linked cone dysfunction syndrome with myopia and dichromacy. Investigative Ophthalmology and Visual Research 54, 1361-1369.
232.Nivison-Smith, L., Collin, S. P., Zhu, Y., Ready, S., Acosta, M.L., Hunt, D. M., Potter, I. C. and Kalloniatis, M. (2013) Retinal amino acid neurochemistry of the southern hemisphere lamprey, Geotria australis. PLoS ONE 8, e58406.
233.Knott, B., Davies, W. I. L., Carvalho, L. S., Berg, M. L., Buchanan, K. L., Bowmaker, J. K., Bennett, A. T. D and Hunt, D. M. (2013) How parrots see their colours: novelty in the visual pigments of Platycercus elegans. Journal of Experimental Biology 216, 4454-4461.
Roles, responsibilities and expertise
Expertise in genetics, molecular biology and biochemistry.
Future research
1. Identification and treatment of disease genes responsible for inherited retinal disease, using mouse and zebrafish models.

2. Application of Next Generation Sequencing to the study of the evolution of the visual system in vertebrates.

3.
Funding received
1.MRC project grant (3 years): "The developmental genetics of the catecholamines and other neurotransmitters". Value £9,760. 1972-75.
2.MRC project grant (3 years): "Congenital defects in the uptake and binding of trace elements". Value £15,027. 1976-79.
3.MRC project grant (3 years): "A study of cellular copper-binding in the mottled mouse mutants". Value £31,986. 1979-82.
4.University of London Central Research Fund for £934. 1982.
5.Visiting Research Fellowship awarded by University of Melbourne, Australia. Value A$7,000. 1983.
6.Wellcome Trust project grant (3 years): "The molecular genetics of vision", with Prof J K Bowmaker and Dr J D Mollon, Department of Experimental Psychology, University of Cambridge. Value £120,000. 1987-90.
7.Project funded by Databird Internatioal (2 years) for the study of "Chromosomal and DNA sexing in birds". Value £60,000. 1990-91.
8.Queen Mary College initiative funding (1 year) for a feasibility study of "Genetic fingerprinting analysis and the behavioural ecology of wild rodents", with Dr John Gurnell. Value £2,591. 1990.
9.Royal Society travel grant for visit in April 1990 to the Limnological Institute in Irkutsk, Siberia to discuss a collaborative project to study the visual pigments of the cottoid fish species flock of Lake Baikal.
10.Royal Society travel grant for expedition to Lake Baikal in August 1990 to collect tissue for the cottoid fish visual pigment project.
11.Royal Society travel grant for second expedition to Lake Baikal in September 1991 to collect additional tissue for the cottoid fish visual pigment project.
12.Royal Society award of £5000 for initial studies on the cottoid fish visual pigment project. 1991.
13.Extension (6 months) to the Wellcome Trust project grant to study "The molecular genetics of vision". Value £12,000. 1991.
14.Leverhulme Trust project grant (3 years): "The molecular genetics of avian colour vision", with Prof J K Bowmaker. Value £78,000. 1991-94.
15.Grant from the Smith-Kline Trust for a project to study the spectral tuning of the blue visual pigments in primates. Value £2,300. 1992.
16.Wellcome Trust project grant (1 year): "Heterologous expression of opsin genes", with Prof J K Bowmaker and Dr J D Mollon, Department of Experimental Psychology, University of Cambridge. Value £35,723. 1992-93.
17.SERC project grant (3 years): "The molecular structure, evolution and ecology of the visual pigments of cottoid fish from Lake Baikal", with Prof J K Bowmaker. Value £164,000. 1993-96.
18.Royal Society travel grant for ARVO Conference. Value £450. 1993.
19.MRC project grant (2 years): "Conserved DNA regions and the regulation of cone opsin gene expression", with Prof J K Bowmaker and Dr J D Mollon, Department of Experimental Psychology, University of Cambridge. Value £220,070. 1993-95.
20.Wellcome Trust project grant (3 years): "Candidate genes in schizophrenia", with Dr J D Mollon, Department of Experimental Psychology, University of Cambridge. Value £196,000. 1993-96.
21.Wellcome prize studentship for Mr Binoy Appukuttan. Value £54,747. 1993-96.
22.Wellcome major equipment grant for the purchase of apparatus for semi-automated DNA sequencing and rapid oil-free PCR, with Prof S S Bhattacharya. Value £107,024. 1993-96.
23.SERC project grant (2 years): "The molecular evolution and spectral tuning of colour vision in hymenoptera", with Prof J K Bowmaker. Value £104,043. 1994-96.
24.MRC project grant (3 years): "Development of a delivery system for gene therapy of inherited retinal degenerations", with Prof S S Bhattacharya and Prof A C Bird (Moorfields Eye Hospital, London). Value £270,000. 1994-97.
25.Wellcome prize studentship for Miss S Sivagnanasundaram. Value £55,455. 1994-97.
26.Wellcome Trust project grant (3 years): "Cone-rod dystrophies in man; linkage and candidate genes", with Prof A C Bird (Moorfields Eye Hospital, London), Mr A Moore (Addenbrokes Hospital, Cambridge) and Dr K Evans. Value £140,465. 1995-98.
27.NERC project grant (3 years): "Evolution and molecular ecology of deep-sea fish visual pigments", with Prof J K Bowmaker and Dr J C Partridge, Department of Zoology, University of Bristol. Value £204,202. 1995-98.
28.BBSRC project grant (3 years): "Evolution, retinal distribution and spectral tuning of avian visual pigments" with Prof J K Bowmaker. Value £180,000. 1995-98.
29.Wellcome Trust project grant (1½ years): "Expression and characterisation of the cone-specific cGMP phosphodiesterase subunits" with Dr M Warren. Value £95,075. 1995-97.
30.Extension (6 months) to Wellcome Trust project grant: "Candidate genes in schizophrenia", with Dr J D Mollon, Department of Experimental Psychology, University of Cambridge. Value £26,435. 1996.
31.Wellcome Trust project grant (3 years): "A study of the role of homologues of Drosophila visual transduction and eye developmental genes in mammalian vision". Value £148,966. 1996-99.
32.Wellcome Trust project grant (1 year): "Isolation and characterisation of a schizophrenia susceptibility gene". Value £62,752. 1996-97.
33.Wellcome Trust project grant (1½ years): "Molecular biological approach to solve the porphyria hypothesis" with Dr M Warren, Prof J C G Röhl (University of Sussex), Prof G H Elder (University of Cardiff). Value £64,411. 1996-98.
34.Wellcome Trust project grant (1 year): "Expression and characterisation of proteins involved in eye development and disease" with Dr M Warren and Prof S S Bhattacharya. Value £86,758. 1997-98.
35.BBSRC project grant (3 years): “Evolution of colour vision in mammals: cone types and opsin genes in a marsupial” with Prof J K Bowmaker. Value £205,000. 1998-2001.
36.Leverhulme Trust project grant (3 years): “Sequence and functional analysis of opsin gene promoter regions in the goldfish” with Prof J K Bowmaker. Value £99,160. 1998-2001.
37.Extension (7 months) to Wellcome Trust project grant: "Cone-rod dystrophies in man; linkage and candidate genes", with Prof A C Bird (Moorfields Eye Hospital, London) and Dr A Moore (Addenbrokes Hospital, Cambridge). Value £30,041. 1998.
38.Wellcome Trust project grant (1 year): "Cone-rod dystrophies in man", with Prof A C Bird (Moorfields Eye Hospital, London) and Dr A Moore (Addenbrokes Hospital, Cambridge). Value £53,463. 1998-1999.
39.Wellcome Trust programme grant (5 years): “Expression and characterisation of proteins involved in retinal disease”, with Dr M Warren and Prof S S Bhattacharya. Value £933,987. 1998-2003.
40.BBSRC project grant (3 years): "Spectral tuning of violet- and ultraviolet-sensitive visual pigments of vertebrates” with Prof J K Bowmaker. Value £235,616. 1999-2002
41.Wellcome Trust project grant (2 years): “Gene therapy for retinal degeneration” with Dr Robin Ali and Prof S S Bhattacharya. Value £134,605. 1999-2001.
42.Extension (12 months) to Wellcome Trust project grant: "A study of the role of homologues of Drosophila visual transduction and eye developmental genes in mammalian vision". Value £51,623. 1999-2000.
43.Extension (6 months) to Wellcome Trust project grant: “Cone-rod dystrophies in man.” Value £26,189. 1999-2000.
44.BBSRC project grant (3 years): "The regulation of opsin gene expression in retinal rods", with Dr J C Partridge, Department of Zoology, University of Bristol. Value £212,080. 1999-2002.
45.Grant for a studentship (3 years) from the British Retinitis Pigmentosa Society for a project entitled “The molecular basis of cone and cone-rod dystrophy” with Prof A T Moore. Value £72,913. 1999-2002.
46.BBSRC project grant (3 years): “Structure/function of cold and pressure adapted enzymes isolated from deep sea fish” with Prof M J Warren, Queen Mary and Westfield College, London and Dr J C Partridge, School of Biology, University of Bristol. Value £171,788. 2000-2003.
47.NERC studentship (3 years): “Visual ecology of deep-sea fish”. 2000-2003.
48.MRC Cooperative Group Grant “Retinal degenerative diseases: an integrated approach from functional genomics to therapies”. 2000-2005.
49.MRC Cooperative component project grant (3 years): “Autosomal dominant retinitis pigmentosa: identification and functional analysis of the RP11 disease gene” with Prof S S Bhattacharya. Value £231,504. 2000-2003.
50.Wellcome Trust Programme Grant (3 years): “Animal models of inherited retinal diseases” with Dr Dominic Wells, Imperial College, London, Prof S S Bhattacharya and Dr R R Ali. Value £354,631. 2001-2004.
51.Guide Dogs for the Blind project grant (2 years): “Cone and cone rod dystrophies: a clinical and molecular genetic investigation” with Prof A T Moore and Prof J D Mollon. Value £91,624. 2001-2003.
52.Leverhulme Trust (3 years): “Evolution of middle-wave and long-wave sensitive cone visual pigments” with Prof J K Bowmaker. Value £119,897. 2001-2004.
53.Wellcome Trust Project Grant (3 years): “X-linked progressive cone-dystrophies: identification of the genes causing COD1 and COD2", with Dr A Hardcastle, Prof S S Bhattacharya, Dr M Cheetham and Prof A T Moore. Value £172,858. 2001-2004.
54.Co-applicant on an Australian Research Council grant entitled “The evolution of colour vision in vertebrates” with Dr Shaun Collin, Dr A E Trezise, Dr J N Marshall, and Professor I C Potts, University of Queensland. 2001-2004.
55.Supervisor for Wellcome Trust Clinical Fellowship for work on human cataract awarded to Dr Anita Arora. Value £185,777
56.EU framework grant: “PRO-AGE-RET”.Grant co-ordinator: Professor José Sahel. Value 112,000 Euros. 2002-2005.
57.Award of AU$5000 from the Distinguished Visitor Fund of the University of Western Australia, Perth, Australia, October 2003.
58.Co-applicant on an Australian Research Council grant entitled “Colour vision in marsupials” with Dr Cathy Arese and Professor L Beazley, University of Western Australia. Value AU$105,000. 2002-2005.
59.Australian Research Council grant entitled “The evolution of dim light vision in vertebrates” with Prof S.Collin, Dr ATrezise, Prof M Kalloniatis, Em/Prof I Potter. 2005-2007.
60.Australian Research Council grant (3 years) entitled “Evolution and function of colour vision in mammals” with Prof L Beazley. 2006-2009.
61.Co-applicant/supervisor on an Iris Fund Clinical Research Fellowship entitled “The identification of genes underlying dominant macular dystrophies with phenotypic similarities to AMD” with Dr Ambreen Kalhoro, Professor A T Moore, and Dr P Francis. Value £100,000. 2005-2006.
62.Grant from the British Retinitis Pigmentosa Society for a project entitled “Functional analysis of mutations in splicing factor genes linked to retinitis pigmentosa” with Professor Martin Warren, Professor Shomi Bhattacharya and Dr Susan Wilkie. Value £118,847. 2005-2007.
63.Grant from the Leverhulme Trust for a project entitled “The evolution of ultraviolet and violet sensitivity in vertebrates” with Professor James K Bowmaker. Value £127,672. 2005-2008.
64.Grant from the Macular Disease Society for a project entitled “A survey of mutation in ABCA4 in 200 juvenile macular dystrophy probands” with Mr A R Webster, Professor A T Moore, and Professor A C Bird. Value £37,108. 2005-2006.
65.Co-applicant on an Australian Research Council grant entitled “Colour vision in birds: consequences to fatal collisions with wind farms” with Dr Cathy Arese, Dr Nathan Hart and Professor L Beazley, University of Western Australia. Value AU$105,000. 2005-2008.
66.Raine Visiting Professorship - Award of AU$9000 from the Raine Medical Research Foundation, University of Western Australia, Perth, Australia, June 2005.
67.Centre Grant awarded by Foundation Fighting Blindness: Module VI “Genetic studies, functional genomics, and animal models of retinal disease” jointly with Prof S S Bhattacharya. Value £340,000. 2005-2010.
68.BBSRC project grant (3 years): "Evolution of photopic and scotopic vision in vertebrates", with Prof J K Bowmaker. Value £210,049. 2005-2008.
69.BBSRC project grant (3 years): "From light into darkness: metamorphic dynamics of the eel retina”, with Prof G Jeffery and Prof J K Bowmaker. Value £213,000. 2006-2009.
70.Grant from the British Retinitis Pigmentosa Society supported by GSK for a project entitled “The identification of genes causing autosomal recessive retinal dystrophy using autozygosity mapping of consanguineous pedigrees.” Value £140,000. 2006-2008.
71.BBSRC project grant (3 years): "A study of the role of Kv8.2, a novel potassium channel gene, in retinal physiology and phototransduction”, with Dr M Stocker, Prof R Ali, Prof T Salt and Dr A Webster. Value £420,000. 2007-2010.
72.Fight for Sight studentship (3 years): “Genetic analysis of inherited developmental macular dystrophies”. Value £92,986. 2007-2010.
73.MRC project grant (3 years): “Pathology and treatment of mouse models of dominant retinal disease” with Prof R R Ali and Dr J Bainbridge. Value £411,057. 2008-2011.
74.Australian Research Council grant (4 years) entitled “Seeing without eyes: the evolution of non-visual photoreceptors in vertebrates” with Prof S Collin, Prof R Foster and Prof I Potter. Value $345,000. 2008-2011.
75.UCLH/UCL Comprehensive Biomedical Research Centre (CBRC) grant (3 years) entitled “Understanding genetic control of brain structure and function: insights and management strategies from inherited eye diseases” with Prof Sanjay Sisodiya, Prof A T Moore and Prof F. Vargha-Khadem. Value £206,568. 2009-2012.
76.Retina Australia grant entitled “Role of a novel miRNA in the dominant syndromic disorder of macular dystrophy and split hand and foot malformation”. Value $30,000. 2011-2012.
77.Lead applicant on UWA-UQ Bilateral Research Collaboration Award entitled “'The zebrafish as a model organism for the study of visual processes and associated inherited disorders in humans” with Professor Brian Key, Professor Shaun Collin, A/Professor Nathan Hart and Dr Arnaud Gaudin. Value $11,964. 2012.
78.WA Department of Commerce grant entitled “Shark Attack Mitigation Wetsuit Design (Zebra Suit)” with Associate Professor Nathan Hart, and Professor Shaun Collin. Value $25,000. 2012.
79.Australian Research Council Discovery grant (3 years) entitled “The evolution of light detection and its impacts on early vertebrate evolution” with Prof S Collin, Prof T Lamb, Prof I Potter and A/Prof N Hart. Value $375,000. 2011-2013.
80.Lead applicant on NHMRC project grant (3 years) entitled “The Role of Potassium Channels in Photoreceptor Function” with Prof Brian Key, A/Professor Nathan Hart, and Professor Shaun Collin. Value $349,338. 2012-2014.
81.Lead applicant on NHMRC project grant (2 years) entitled “Myopia & Colour Vision” with Professor David Mackey. Value $222,450. 2012-2013.
82.Leverhulme Trust project grant (3 years) entitled “Insights from snakes into vertebrate visual evolution” with Dr David J Gower (UK Natural History Museum), A/Professor Nathan S hart, and Professor Julian Partridge (University of Bristol). Value £194,949. 2012-2015.
83.Australian Research Council Discovery grant (3 years) entitled “Transcriptome sequencing and functional characterisation of craniate non-visual sensory systems and their adaptation to diverse light environments” with A/Prof Wayne Davies, A/Prof Kim Carter, A/Prof Jan Hemmi, Prof Julian Partridge. Value $380,000. 2014-2016.
84.Lead applicant on a Australian Research Council LIEF grant to establish a zebrafish facility in WA, with Prof Ryan Lister, A/Prof Nathan Pavlos, Prof Shaun Collin, A/Prof Wayne Davies, Prof Ralph Martins, A/Prof Simon Laws and Dr Guiseppe Verdene. Value $400,000.

Languages
English
Memberships
Association for Research in Vision and Ophthalmology.
UK Genetics Society

Past treasurer of the UK Genetics Society and International Genetics Federation.
Previous positions
2010-2014Winthrop Professor, University of Western Australia
2007-Emeritus Professor, University College London
2007-2010Professorial Fellow, Institute of Ophthalmology, University College London
1996-2007Professor of Molecular Genetics, Institute of Ophthalmology, University College London
1994-96Reader in Molecular Genetics, Institute of Ophthalmology, University College London
1992-94Senior Lecturer in Molecular Genetics, Institute of Ophthalmology, University of London
1989-92Senior Lecturer in Genetics, Queen Mary & Westfield College, University of London
1974-89Lecturer in Genetics, Queen Mary College, University of London
1972-74Lecturer in Genetics, Department of Genetics, University of Glasgow
1967-72Research Associate, MRC Experimental Genetics Unit, University College London
1964-67SERC research studentship, Department of Genetics, University of Sheffield
2007-2010Professorial Fellow, Institute of Ophthalmology, University College London
1996-2007Professor of Molecular Genetics, Institute of Ophthalmology, University College London
1994-1996Reader in Molecular Genetics, Institute of Ophthalmology, University College London
1992-1994Senior Lecturer in Molecular Genetics, Institute of Ophthalmology, University of London
1989-1992Senior Lecturer in Genetics, Queen Mary & Westfield College, University of London
1974-1989Lecturer in Genetics, Queen Mary College, University of London
1972-1974Lecturer in Genetics, Department of Genetics, University of Glasgow
1967-1972Research Associate, MRC Experimental Genetics Unit, Department of Animal Genetics, University College London
Research profile
Research profile and publications
 

The University of Western Australia

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