The University of Western Australia

UWA Staff Profile

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David Mackey

Professor David Mackey

Managing Director and Chair of UWA Ophthalmology/Head of Genetics and Population Health
Ophthalmology and Visual Science, Centre for (affiliated with the Lions Eye Institute)

Contact details
Address
Centre for Ophthalmology and Visual Science (affiliated with the Lions Eye Institute)
The University of Western Australia
2 Verdun St
PERTH WA 6009
Australia
Phone
+61 8 9381 0841
Email
david.mackey@uwa.edu.au

Head—Genetics and Population Health
COVS/Research Staff/Genetics and Population Health

Contact details
Address
COVS/Research Staff/Genetics and Population Health
The University of Western Australia (M517)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 9381 0841
Email
david.mackey@uwa.edu.au
Qualifications
MB BS Tas., MD Melb. FRANZCO, FRACS
Biography
Professor David Mackey is internationally renowned as a world-leading researcher in genetic and environmental factors causing eye disease, having spent over 20 years studying the genetics of the eye. In 2005 he was awarded a Pfizer Australia Senior Research Fellowship and in 2010 was an Alcon Research Institute Awardee. Before moving to Western Australia in 2009, he was Associate Professor at the University of Melbourne’s Department of Ophthalmology and Clinical Professor at the University of Tasmania.
He coordinated an international consortium to establish the frequency of Leber Hereditary Optic Neuropathy mutations in 130 pedigrees. His work identified two of the three main mutations and established the phenotype-genotype correlations (in particular genetic and age risk for visual recovery).
In 1993 David initiated the Glaucoma Inheritance Study in Tasmania, thereby creating one of the largest glaucoma biobanks in the world, that led to the discovery of the myocilin gene and its association with glaucoma. His group has also developed a model of cascade family screening for glaucoma.
The Twins Eye Study in Tasmania and Brisbane has characterised the heritability of many ocular measurements and Genome Wide Association Studies have identified genes for myopia, corneal thickness, intra-ocular pressure optic nerve size and glaucoma.
In 2007-8, he led the Norfolk Island Eye Study, examining 800 mixed race descendants of the Bounty Mutineers as part of a major genetic eye study.
In Western Australia, he has collected ocular and environmental data on 2000 20-year old Raine Cohort participants. A follow-up study of these participants at age 27 years has been funded by the NHMRC commencing in 2017. A new study begun in 2012 is examining the positive-negative effects of UV sun exposure.

Key research
Professor Mackey has devoted his career to decreasing blindness from optic nerve disorders. His work has revolutionised the management of two serious hereditary eye diseases, particularly clinical and molecular genetic aspects of:
• Hereditary Optic Atrophy (Leber and ADOA)
• Glaucoma
He also studies the genetic influences in the following eye diseases:
• Age-related macular degeneration, retinal dystrophies and retinal detachment
• Strabismus and Ptosis
• Corneal dystrophies, Keratoconus and Myopia
His research is focussed through several studies:
• Twins Eye Studies
• Glaucoma Inheritance Study in Tasmania
• Norfolk Island Eye Study
• Raine Cohort eye health study
• Busselton Healthy Aging Study
Publications
Professor Mackey has been an author on over 340 publications since 1989. ISI Web of Science has calculated his H Index at 50; a total of 8635 citations (without self-cites) at an average of 24.17 citations per article; and 21 publications with more than 100 citations.
Roles, responsibilities and expertise
Managing Director, Lions Eye Institute
Director & Professor of Ophthalmology, UWA Centre for Ophthalmology and Visual Science
Member, Faculty Research Committee, UWA Faculty of Medical and Health Sciences

2013-2015 Member, Medical & Dental Workforce Council, Western Australian Department of Health
2012-2015 Member, NHMRC Human Genetics Advisory Committee
2009-2010 Member, NHMRC Panel for the evidence based medicine guidelines for glaucoma
2016- Mentor, Leadership Development Program for Women in ARVO
2015- Member, RANZCO Leadership Development Program
2016 Regional Secretary (Australia & New Zealand), Asia-Pacific Academy of Ophthalmology
2012-2016 President, International Society for Genetic Eye Disease and Retinoblastoma
2015- Chair, Scientific Advisory Committee, Ophthalmic Research Institute Australia
2015- Member, Executive Committee, Glaucoma Research Society
2011- Member, Basic and Clinical Science Course (BCSC) Sect. 2 Subcommittee, Fundamentals and Principles of Ophthalmology, American Academy of Ophthalmology
2013- Member, Raine Study Executive Committee
2014- Member, Raine Study Genetics Advisory Subcommittee

Funding received
Since 1990 David Mackey has received over $22 million in funding, with continuous NHMRC funding since 2000. Over the past five years, he has been awarded almost $13M in research funding as a Chief Investigator. He is currently funded by the NHMRC as CIA on one CRE, one Partnership, one Project grant and CI on three other project grants. In addition he is CI on two Western Australian Government research grants.
Memberships
American Academy of Ophthalmology
American Society of Human Genetics
Association for Research in Vision & Ophthalmology (Silver Fellow)
Glaucoma Research Society
Human Genetics Society of Australia
International Society for Genetic Eye Disease and Retinoblastoma (Past President)
Ophthalmic Genetics Study Club
Honours and awards
Franceschetti Lecture, International Society for Genetic Eye Diseases and Retinoblastoma, 2017
Asia Pacific Academy of Ophthalmology Achievement Award 2016
Marshall M Parks Lecture, American Academy of Ophthalmology meeting, 2015.
American Academy of Ophthalmology Achievement Award 2015
Kevin Bell Churchill Fellowship Trust Award 2015
Elected Fellow of the Australian Academy of Health and Medical Sciences 2015
Harvard Club of Australia Nonprofit Fellowship Award: Strategic Perspectives in Nonprofit Management one week live-in course Boston 2014
RANZCO Excellence in Training Award 2012
Asia-Pacific Academy of Ophthalmology Distinguished Service Award 2011
Alcon Research Institute Award, 2010 for outstanding contribution to vision research
University Foundation Graduate Award, University of Tasmania, 2009
Prize for Best Poster RANZCO 2007.
Prize for the best scientific presentation at the European Glaucoma Society Meeting London June 2000.
Awarded prize for the best scientific presentation at the European Glaucoma Society Meeting Paris June 1996.
Kabi Pharmacia award for the best scientific paper at the 1993 at the Royal Australian College of Ophthalmologists, annual scientific meeting Hobart.
Founders Cup and £250 for the best scientific paper at the 1993 Oxford Ophthalmological Congress.
Rudin Prize (New York Academy of Medicine) for the best glaucoma paper published in the world in 1997.
Previous positions
2011-2016: Council Member: Royal Australian & New Zealand College of Ophthalmologists
2008- : Clinical Professor, University of Tasmania
2005-2009: Pfizer Australia Senior Research Fellow
1997- : Assoc Prof, University of Melbourne Dept of Ophthalmology
1995- : Ophthalmologist, Royal Hobart Hospital
1993-2009: Ophthalmologist, Dept of Ophthalmology, Royal Children's Hospital, Melbourne
1993-2009: Ophthalmologist-in-charge, Ocular-Diagnostic (Genetic) Clinic, Royal Victorian Eye and Ear Hospital, Melbourne
1998-2003: Associate, Murdoch Institute, University of Melbourne
1996-2004: Associate, Menzies Institute, University of Tasmania
1996: Convenor of the XI Symposium of the International Society for Genetic Eye Disease (ISGED) and the VIII Symposium of the Retinoblastoma Society, Hobart, Tasmania; March 10-14 1996.
1994-96: Senior Lecturer University of Melbourne Department of Paediatrics.
1993: Wellcome Research Fellow, Clinical Fellow in Hereditary eye diseases, with Alan Bird, Marcelle Jay and Anthony Moore, Moorfields Eye Hospital, Visiting Clinical Fellow in Paediatric Ophthalmology, Hospitals for Sick Children, Great Ormond St, London.
1991-93: Clinical Fellow in Ophthalmology, Johns Hopkins Center for Hereditary Eye Disease, Baltimore, MD, USA.
1990-1991: Clinical Research Fellow in Ophthalmology, Royal Children's Hospital, Melbourne, Vic.
1987-1989: Registrar Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Vic.
1986: Senior Resident Medical Officer (Surgery), Royal Hobart Hospital, Hobart, Tas.
1985: Junior Resident Medical Officer, Launceston General Hospital, Launceston, Tas.
1984: Intern, Launceston General Hospital, Launceston, Tas.
Teaching
Professor Mackey has supervised 29 Higher Degree students, including the following former PhD students:
Associate Professor Kathryn Burdon (now at UTas) Email: Kathryn.Burdon@utas.edu.au
Associate Professor Alex Hewitt (now at UTas) Email: hewitt.alex@gmail.com
Dr Paul Sanfillippo (now at UMelb) Email: prseye@gmail.com
Dr Seyhan Yazar (NHMRC CJ Martin early career Fellowship) Email: seyhanyazar@gmail.com
He coordinates weekly higher degree student group meetings, using a "6Rs" teaching framework to guide and develop the next generation of clinicians and scientists:
• Relevance (disease based projects)
• Rigour (sound science with tight timelines)
• Relationship (strong supervisory and mentoring program)
• Reading literature (journal clubs)
• ‘Riting and presenting work
• ‘Rithmatic (statistical genetics courses)
He also participates at the regular clinical ophthalmology teaching skills workshops held for UWA/Notre Dame medical students.



Current external positions
Board member: Ophthalmic Research Institute of Australia
Member: Basic and Clinical Science Course (BCSC) Sect. 2 Subcommittee, Fundamentals and Principles of Ophthalmology, American Academy of Ophthalmology
Current projects
Raine Eye Health Study
Busselton Healthy Aging Study
Western Australian Eye Protection Study
Twins Eye Study in Tasmania
Glaucoma Inheritance Study in Tasmania
Norfolk Island Eye Study
Consortium for Refractive Error and Myopia
International Glaucoma Genetics Consortium
RFCD
321016
Research profile
Research profile and publications
 

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Last updated:
Tuesday, 3 November, 2015 2:39 PM