Professor David Mackey
Managing Director and Chair of UWA Ophthalmology/Head of Genetics and Population Health/Associate Dean (Research)
Ophthalmology and Visual Science, Centre for (affiliated with the Lions Eye Institute)
- Contact details
- Centre for Ophthalmology and Visual Science (affiliated with the Lions Eye Institute)
The University of Western Australia
2 Verdun St
PERTH WA 6009
- +61 8 9381 0841
Head—Genetics and Population Health
COVS/Research Staff/Genetics and Population Health
- Contact details
- COVS/Research Staff/Genetics and Population Health
The University of Western Australia (M517)
35 Stirling Highway
CRAWLEY WA 6009
- +61 8 9381 0841
- MB BS Tas., MD Melb. FRANZCO, FRACS
- Professor David Mackey has achieved international recognition as a genetic ophthalmologist having spent 20 years studying the genetics of the eye. In 2005 he was awarded a Pfizer Australia Senior Research Fellowship and in 2010 was an Alcon Research Institute Awardee. Before moving to Western Australia in 2009, he was Associate Professor at the University of Melbourne’s Department of Ophthalmology and Clinical Professor at the University of Tasmania.
He coordinated an international consortium to establish the frequency of Leber’s Hereditary Optic Neuropathy mutations in 130 pedigrees. His work identified two of the three main mutations and established the phenotype-genotype correlations (in particular genetic and age risk for visual recovery).
In 1993 David initiated the Glaucoma Inheritance Study in Tasmania, thereby creating one of the largest glaucoma biobanks in the world, that led to the discovery of the myocilin gene and its association with glaucoma. His group has also developed a model of cascade family screening for glaucoma.
The Twins Eye Study in Tasmania and Brisbane has characterised the heritability of many ocular measurements and Genome Wide Association Studies have identified genes for myopia, corneal thickness, intra-ocular pressure optic nerve size and glaucoma.
In 2007-8, he led the Norfolk Island Eye Study, examining 800 mixed race descendants of the Bounty Mutineers as part of a major genetic eye study.
In Western Australia, he has collected ocular and environmental data on 2000 20-year old Raine Cohort participants. A new study begun in 2012 is examining the positive-negative effects of UV sun exposure.
- Key research
- Hereditary eye diseases, particularly clinical and molecular genetic aspects of:
- • Hereditary Optic Atrophy (Lebers and ADOA)
- • Glaucoma
- • Age-related macular degeneration, retinal dystrophies and retinal detachment
- • Strabismus and Ptosis
- • Corneal dystrophies, Keratoconus & Myopia
- • Twins Eye Studies
- • Norfolk Island Eye Study
- • Raine Eye Health Study
- • Busselton Healthy Aging Study
- 300 peer reviewed publications with 33 of these being cited over 100 times in other research publications.
- Australian Medical Association
American Academy of Ophthalmology
American Society of Human Genetics
Association for Research in Vision & Ophthalmology
Glaucoma Research Society
Human Genetics Society of Australia
International Society for Genetic Eye Disease and Retinoblastoma
Oxford Ophthalmological Congress
Ophthalmic Genetics Study Club
Australian Institute of Company Directors
- Honours and awards
- Marshall M Parks Lecture, American Academy of Ophthalmology meeting, 2015.
American Academy of Ophthalmology Achievement Award 2015
Regional Secretary (Australia & New Zealand), Asia-Pacific Academy of Ophthalmology 2015 – current.
Kevin Bell Churchill Fellowship Trust Award 2015
Elected Fellow of the Australian Academy of Health and Medical Sciences 2015
Harvard Club of Australia Nonprofit Fellowship Award: Strategic Perspectives in Nonprofit Management one week live-in course Boston 2014.
Member, NHMRC Human Genetics Advisory Committee 2012-2015
President, International Society for Genetic Eye Disease and Retinoblastoma 2012-16
RANZCO Excellence in Training Award 2012
Asia-Pacific Academy of Ophthalmology Distinguished Service Award 2011
Member, Basic and Clinical Science Course (BCSC) Sect. 2 Subcommittee, Fundamentals and Principles of Ophthalmology, American Academy of Ophthalmology (2011 – current)
Alcon Research Institute Award, 2010
University Foundation Graduate Award, University of Tasmania, 2009
Prize for Best Poster RANZCO 2007.
Prize for the best scientific presentation at the European Glaucoma Society Meeting London June 2000.
Awarded prize for the best scientific presentation at the European Glaucoma Society Meeting Paris June 1996.
Kabi Pharmacia award for the best scientific paper at the 1993 at the Royal Australian College of Ophthalmologists, annual scientific meeting Hobart.
Founders Cup and £250 for the best scientific paper at the 1993 Oxford Ophthalmological Congress.
Rudin Prize (New York Academy of Medicine) for the best glaucoma paper published in the world in 1997.
- Previous positions
- 2011-2016: Council Member: Royal Australian & New Zealand College of Ophthalmologists
2008- : Clinical Professor, University of Tasmania
2005-2009: Pfizer Australia Senior Research Fellow
1997- : Assoc Prof, University of Melbourne Dept of Ophthalmology
1995- : Ophthalmologist, Royal Hobart Hospital
1993-2009: Ophthalmologist, Dept of Ophthalmology, Royal Children's Hospital, Melbourne
1993-2009: Ophthalmologist-in-charge, Ocular-Diagnostic (Genetic) Clinic, Royal Victorian Eye and Ear Hospital, Melbourne
1998-2003: Associate, Murdoch Institute, University of Melbourne
1996-2004: Associate, Menzies Institute, University of Tasmania
1996: Convenor of the XI Symposium of the International Society for Genetic Eye Disease (ISGED) and the VIII Symposium of the Retinoblastoma Society, Hobart, Tasmania; March 10-14 1996.
1994-96: Senior Lecturer University of Melbourne Department of Paediatrics.
1993: Wellcome Research Fellow, Clinical Fellow in Hereditary eye diseases, with Alan Bird, Marcelle Jay and Anthony Moore, Moorfields Eye Hospital, Visiting Clinical Fellow in Paediatric Ophthalmology, Hospitals for Sick Children, Great Ormond St, London.
1991-93: Clinical Fellow in Ophthalmology, Johns Hopkins Center for Hereditary Eye Disease, Baltimore, MD, USA.
1990-1991: Clinical Research Fellow in Ophthalmology, Royal Children's Hospital, Melbourne, Vic.
1987-1989: Registrar Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Vic.
1986: Senior Resident Medical Officer (Surgery), Royal Hobart Hospital, Hobart, Tas.
1985: Junior Resident Medical Officer, Launceston General Hospital, Launceston, Tas.
1984: Intern, Launceston General Hospital, Launceston, Tas.
- Former PhD students
Associate Professor Kathryn Burdon (now at UTas) Email: Kathryn.Burdon@utas.edu.au
Associate Professor Alex Hewitt (now at UTas) Email: firstname.lastname@example.org
Dr Paul Sanfillippo (now at UMelb) Email: email@example.com
Dr Seyhan Yazar (NHMRC CJ Martin early career Fellowship) Email: firstname.lastname@example.org
- Current external positions
- Board member: Ophthalmic Research Institute of Australia
Member: Basic and Clinical Science Course (BCSC) Sect. 2 Subcommittee, Fundamentals and Principles of Ophthalmology, American Academy of Ophthalmology
- Current projects
- Raine Eye Health Study
Busselton Healthy Aging Study
Western Australian Eye Protection Study
Twins Eye Study in Tasmania
Glaucoma Inheritance Study in Tasmania
Norfolk Island Eye Study
- Research profile
Research profile and publications