The University of Western Australia

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Gavin Flematti

Dr Gavin Flematti

Senior Lecturer
Molecular Sciences, School of

Contact details
Address
School of Molecular Sciences
The University of Western Australia (M313)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 6488 4461
Fax
+61 8 6488 1005
Email
gavin.flematti@uwa.edu.au
Location
Room 417, Bayliss Building, Perth campus
Qualifications
PhD W.Aust.
Biography
Dr Gavin Flematti completed his undergraduate and PhD studies at UWA, followed by post-doctoral studies and a prestigious Australian Future Fellowship award at UWA. He currently holds a teaching and research position in the School of Chemistry and Biochemistry at UWA.
Key research
Natural Products and Chemical Ecology
The primary research interest in the Flematti Lab is the isolation and identification of bioactive natural products. The specific activity of these compounds ranges from antibacterial and anticancer activity, through to organism defence and chemical communication. As well as traditional natural product extraction and isolation, we make use of sophisticated analytical instruments including HPLC, GC-MS, HPLC-MS and more recently GC-EAD/MS, to aid in the detection and isolation of bioactive compounds, which are characterised using NMR spectroscopy and high resolution MS techniques. Depending on the structure and function, interesting compounds are confirmed through chemical synthesis.
Publications
Book Chapters

Flematti, G.R., Ghisalberti, E.L., Dixon, K.W., Trengove, R.D. Germination Stimulant in Smoke: Isolation and Identification in Bioactive Natural Products: Detection, Isolation and Structural Determination 2nd Edition CRC Press. Edited by Steven M. Colegate and Russell J. Molyneux (2008).

Selected Journal articles

Zhang Y, van Dijk ADJ, Scaffidi A, Flematti GR, Hofmann M, Charnikhova T, Verstappen F, Hepworth J, van der Krol S, Leyser O, Smith SM, Zwanenburg B, Al-Babili S, Ruyter-Spira C, Bouwmeester HJ. Rice cytochrome P450 MAX1 homologs catalyze distinct steps in strigolactone biosynthesis. Nature Chemical Biology, 10, 1028-1033, (2014).

Scaffidi A, Waters M, Sun YK, Skelton BW, Dixon KW, Ghisalberti EL, Flematti GR, Smith SM. Strigolactone hormones and their stereoisomers signal through two related receptor proteins to induce different physiological responses in Arabidopsis. Plant Physiology, 165, 1221-1232, (2014).

Bohman B, Phillips RD, Menz MHM, Berntsson BW, Flematti GR, Barrow RA, Dixon KW, Peakall RD. Discovery of pyrazines as pollinator sex pheromones and orchid semiochemicals: implications for the evolution of sexual deception. New Phytologist, 203, 939-952, (2014).

Waters MT, Scaffidi A, Flematti GR, Smith SM: The origins and mechanisms of karrikin signalling. Current Opinion in Plant Biology. 16, 667-673, (2013).

Flematti GR, Waters MT, Scaffidi A, Merritt DJ, Ghisalberti EL, Dixon KW, Smith SM: Karrikin and Cyanohydrin Smoke Signals Provide Clues to New Endogenous Plant Signaling Compounds. Molecular Plant, 6, 29-37. (2013).

Nelson D.C., Flematti G.R., Ghisalberti, E. L., Dixon K. W., Smith, S.M. Regulation of seed germination and seedling growth by chemical signals from burning vegetation. Annual Review of Plant Biology. 63, 107-130, (2012).

Flematti, G. R. Merritt, D. J., Piggott, M. J., Trengove, R. D., Smith, S. M., Dixon, K. W. Ghisalberti, E. L. Burning vegetation produces cyanohydrins that liberate cyanide and stimulate seed germination, Nature Communications, 2, 360, DOI:10.1038/ncomms1356, (2011).

Nelson, D. C., Scaffidi, A, Dun, E. A., Waters, M., Flematti, G. R., Dixon, K. W., Beveridge, C. A., Ghisalberti, E. L., Smith, S.M. The F-box protein MAX2 has dual roles in karrikin and strigolactone signaling in Arabidopsis thaliana, Proceedings of the National Academy of Science, USA, 108, 8897-8902, (2011).

Nelson, D. C., Flematti, G.R., Riseborough, J.A., Ghisalberti, E.L, Dixon, K. W., Smith, S.M. Karrikins enhance light responses during germination and seedling emergence in Arabidopsis thaliana. Proceedings of the National Academy of Science, USA, 107, 7095-7100 (2010).

Flematti, G.R., Goddard-Borger, E.D., Merritt, D.J., Ghisalberti, E.L., Dixon, K.W., Trengove, R.D. Preparation of 2H-furo[2,3-c]pyran-2-one derivatives and evaluation of their germination-promoting activity. Journal of Agricultural and Food Chemistry, 55, 2189-2194 (2007).

Flematti, G.R., Ghisalberti, E.L., Dixon, K.W., Trengove, R.D. Synthesis of the seed germination stimulant 3-methyl-2H-furo[2,3-c]pyran-2-one. Tetrahedron Letters, 46, 5719-5721, (2005)

Flematti, G.R., Ghisalberti, E.L., Dixon, K.W., Trengove, R.D. A compound from smoke that promotes seed germination. Science, 305, 977 (2004)
Funding received
ARC Discovery Grants
ARC Linkage Grant
ARC Future Fellowship
Memberships
Royal Australian Chemistry Institute
Honours and awards
2005 Royal Australian Chemistry Institute Cornforth Medal for Best PhD Thesis in the Chemical Sciences
Patents
Flematti, G.R., Ghisalberti, E.L., Dixon, K.W., Trengove, R.D. Vinylogous 4H-pyrones and their preparation and use in promoting plant growth. PCT International Application, WO 2005061515, (2005).
Teaching
CHEM2001 Core Chemical Concepts and Techniques
CHEM2003 Chemical Synthesis
MSCI4006 Advanced Techniques in Molecular Sciences
Current projects
Collaborators

Dr Kingsley Dixon, Kings Park and Botanic Garden
Dr David Merritt, Kings Park and Botanic Garden
Dr Jason Stephens, Kings Park and Botanic Garden
A/Prof Emilio Ghisalberti, Chemistry UWA
Prof Steven Smith, UWA
Dr David Nelson, University of Georgia, USA
A/Prof Rob Trengove, Murdoch University
Research profile
Research profile and publications
 

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Last updated:
Tuesday, 3 November, 2015 2:39 PM