The University of Western Australia

UWA Staff Profile

Ipsum Lorem

W/Prof Jiake Xu

Winthrop Professor/Head of Molecular Laboratory
Pathology and Laboratory Medicine

Contact details
Address
Pathology and Laboratory Medicine
The University of Western Australia (M504)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 6457 2739
Fax
+61 8 6457 2891
Email
jiake.xu@uwa.edu.au
Location
Room 1.4H, M Block, QEII Medical Centre, Nedlands

Head
Regenerative Biology

Contact details
Address
Regenerative Biology
The University of Western Australia (M504)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 6457 2739
Fax
+61 8 6457 2891
Email
jiake.xu@uwa.edu.au
Location
Room 1.4H, M Block, QEII Medical Centre, Nedlands
Qualifications
MB BS Guangzhou, PhD W.Aust.
Publications
Prof Xu has published over 160 SCI papers in journals; including Nature Medicine, Nature Communications, PNAS, Mol. Cell. Biol. , J Biol. Chem. , J Bone Miner Res. , Am J Pathol, and Endocrine Reviews. Recent selected publications include:
1. Feng H, Cheng T, Pavlos N, Yip KH, Seeber R, Eidne K, Zheng MH, Xu J (2008) Cytoplasmic terminus of a vacuolar type proton pump accessory subunit Ac45 is required for proper interaction with V0 domain subunits and efficient osteoclastic bone resorption. J Biol Chem. 9;283(19):13194-204.
2. Feng H, Cheng T, Steer JH, Joyce DA, Pavlos NJ, Leong C, Kular J, Liu J, Feng X, Zheng MH, Xu J. (2009) MEF2 and MITF cooperate with NFATC1 to transactivate the V-ATPase D2 promoter during RANKL-induced osteoclastogenesis. J Biol Chem. 22;284(21):14667-76.
3. Cheng T, Pavlos NJ, Wang C, Tan JW, Lin JM, Cornish J, Zheng MH, Xu J. (2009) Mutations within the TNF-like core domain of RANKL impair osteoclast differentiation and activation. Mol Endocrinol. 23(1):35-46.
4. Xu J, Wu HF, Ang ESM, Yip K, Woloszyn M, Zheng MH, Tan RX (2009) NF-kB modulators in osteolytic bone diseases. Cytokine Growth Factor Rev. 20(1):7-17.
5. Rea SL, Walsh JP, Ward L, Magno AL, Ward BK, Shaw B, Layfield R, Kent GN, Xu J, Ratajczak T. (2009) Sequestosome 1 Mutations in Paget's Disease of Bone in Australia: Prevalence, Genotype/Phenotype Correlation and a Novel Non-UBA Domain Mutation (P364S) Associated with Increased NF-kappaB Signaling Without Loss of Ubiquitin-Binding. J Bone Miner Res. 24(7):1216-23.
6. Pavlos NJ, Cheng TS, Qin A, Ng PY, Feng HT, Ang ES, Carrello A, Sung CH, Jahn R, Zheng MH, Xu J (2011) Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption. Mol. Cell. Biol 31(7):1551-64.
7. Chim SM, Qin A, Tickner J, Pavlos NJ, Davey T, Wang H, Guo Y, Zheng MH, Xu J. (2011) EGFL6 promotes endothelial cell migration and angiogenesis through the activation of ERK. J Biol Chem. 286(25):22035-46.
8. Guo J, Ren F, Wang Y, Li S, Gao Z, Wang X, Ning H, Wu J, Li Y, Wang Z, Chim SM, Xu J, Chang Z. (2012) miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression. J Bone Miner Res. 2012 Mar 9.
9. Thomas E, Lee-Pullen T, Rigby P, Hartmann P, Xu J, Zeps N. (2012) Receptor Activator of NF-κB Ligand Promotes Proliferation of a Putative Mammary Stem Cell Unique to the Lactating Epithelium. Stem Cells. 30(6):1255-64.
10. Rea SL, Walsh JP, Layfield R, Ratajczak T, Xu J. (2013) New insights into the role of Sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone. Endocrine Reviews. 34(4):501-24 (IF 19.75).
11. Liang C, Guo B, Wu H, Shao N, Li D, Liu J, Dang L, Wang C, Li H, Li S, Lau W, Yang Z, Lu C, He X, Au DWT, Pan X, Zhang B, Lu C, Zhang H, Yue K, Qian A, Shang P, Xu J, Xiao L, Bian Z, Tan W, Liang Z, He F, Zhang L, Lu A, Zhang G. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat Med. 2015 Mar;21(3):288-94.
12. Kular J, Tickner JC, Pavlos NJ, Viola HM, Abel T, Lim BS, Yang X, Chen H, Cook R, Hool LC, Zheng MH, Xu J. Choline Kinase Beta Mutant Mice Exhibit Reduced Phosphocholine, Elevated Osteoclast Activity and Low Bone Mass. J Biol Chem. 2015 Jan 16;290(3):1729-42.


Research profile
Research profile and publications
 

The University of Western Australia

This Page

Last updated:
Tuesday, 3 November, 2015 2:39 PM