The University of Western Australia

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Kevin Croft

Professor Kevin Croft

Professorial Fellow
Medicine and Pharmacology, School of, Royal Perth Hospital Unit

Contact details
School of Medicine and Pharmacology Royal Perth Hospital Unit
The University of Western Australia (M570)
35 Stirling Highway
+61 8 9224 0275
+61 8 9224 0246
BAppChem Curtin, PhD W.Aust.
Professorial Fellow in the School of Medicine and Pharmacology.
Key research
Nutrition and cardiovascular disease. Antioxidants and oxidative stress.
Arachidonic acid metabolism by CYP450 pathway,
ethothelial function, blood pressure.
Biomarkers of oxidative damage.
Dietary polyphenol metabolism.
>275 peer reviewed publications, examples of recent publications include;
Waddington E, Puddey IB, Croft KD. Red wine polyphenolic compounds inhibit atherosclerosis in apolipoprotein E-deficient mice independent of effects on lipid peroxidation. Am J Clin Nutr. 79: 54-61, 2004.
Ward NC, Rivera J, Hodgson JH, Puddey IB, Beilin LJ,Falck JR, Croft KD. Urinary 20-Hydroxyeicosatetraenoic Acid is Associated with Endothelial Dysfunction in Humans. Circulation 110: 438-443, 2004.
Wu J, Hodgson JM, Ward NC, Clarke MW, Puddey IB, Croft KD. Nitration of -tocopherol prevents its oxidative metabolism by HepG2 cells. Free Radic Biol Med 39: 483-494, 2005.
Clarke MW, Ward NC, Wu JHY, Hodgson JM, Puddey IB, Croft KD. Supplementation with mixed tocopherols increases serum and blood cell gamma-tocopherol, but does not alter biomarkers of platelet activation in subjects with type 2 diabetes. Am J Clin Nutr 83: 95-102, 2006.
Ward NC, Wu J, Clarke MW, Puddey IB, Burke V, Croft KD, Hodgson JM. The effects of Vitamin E on blood pressure in individuals with type 2 diabetes. A randomised, double-blind, placebo controlled trial. J Hypertension 25: 227-234, 2007.
Wu JHY, Ward N, Indrawan AP, Almeida CA, Hodgson JM, Proudfoot JM, Puddey IB, Croft KD. Effects of α-tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetes. Clinical Chemistry 53: 511-519, 2007.
Datla S, Dusting GJ, Mori TA, Taylor CJ, Croft KD, Jiang F. Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase-derived oxidative stress. Hypertension 50: 636-642, 2007.
Tsai IJ, Beilin LJ, Puddey IB, Croft KD, Barden A, Impaired ex vivo leukotriene B4 production characterizes the metabolic syndrome and is improved after weight reduction. J Clin Endocrinology & Metabolism 92: 4747-4752, 2007.
Loke WM, Proudfoot JM, Stewart S, McKinley AJ, Needs PW, Kroon PA, Hodgson JM, Croft KD. Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: Lack of association between antioxidant and lipoxygenase inhibitory activity. Biochem Pharmacol. 75: 1045-1053, 2008.
Ward NC, Tsai IJ, Barden A, van Bockxmeer FM, Puddey IB, Hodgson JM, Croft KD. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and BP. Hypertension 51: 1393-1398, 2008.
Woodward M, Croft KD, Mori TA, Headlam H, Wang XS, Suarna C, Raftery MJ, MacMahon SW, Stocker R. The association between both lipid and protein oxidation and the risk of fatal or non-fatal coronary heart disease in a human population. Clin Sci. 116: 53-60, 2009.
Loke WM, Hodgson JM, Proudfoot JM, McKinley AJ, Puddey IB, Croft KD. Pure dietary flavonoids, quercetin and (-) epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy human volunteers. Am J Clin Nutr 88: 1018-1025, 2008.
Loke WM, Proudfoot JM, Hodgson JM, McKinley AJ, Hime N, Magat M, Stocker R, Croft KD. Specific dietary Polyphenols attenuate atherosclerosis in apoE-knockout mice by alleviating inflammation and endothelial dysfunction. Arterioscl Throm Vasc Biol 30: 749-757, 2010.
Hodgson JM, Croft KD. Tea flavonoids and cardiovascular health. Mol Aspects Med 31: 495-502, 2010.
Hodgson, JM; Puddey IB; Woodman RJ; Mulder T; Fuchs D; Scott K; Croft KD. Effects of black tea on blood pressure: a randomized controlled trial. Archives of Internal Medicine 172: 186-188, 2012.
Mubarak A , Bondonno CP, Liu A, Rich L, Considine MJ, Mas E, Hodgson JM, Croft KD. Acute effects of chlorogenic acid on nitric oxide status, endothelial function and blood pressure in healthy men and women. J Ag Food Chem 60: 9130-9136, 2012.
Yang X, Bondono CP, Hodgson JM, Croft KD. An improved mass spectrometry based measurement of NO metabolites in biological fluids. Free Rad Biol Med. 56: 1-8, 2013.
Yu Shen, Ward N, Hodgson JM, Puddey IB, Wang Y, Zhang D; Maghzal GJ, Stocker R, Croft KD. Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1. Free Rad Biol Med 65: 908-915, 2013.
Barden AE, Mas E, Croft KD, Phillips M, Mori TA. Short-Term n-3 Fatty Acid Supplementation but not Aspirin Increases Plasma Proresolving Mediators of Inflammation. J Lipid Research 55: 2401–2407, 2014.
Ivey KL, Hodgson JM, Croft KD, Lewis JR, Prince RL. Flavonoid intake and all-cause mortality. Am J Clin Nutr 101: 1012-1020, 2015.
Bondonno CP, Liu AH, Croft KD, Ward NC, Shinde S, Moodley Y, Lundberg J, Puddey IB, Woodman RJ, Hodgson JM. Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomised controlled trial. Am J Clin Nutr 102: 368-375, 2015.
Bondonno CP, Liu AH, Croft KD, Ward NC, Shinde S, Moodley Y, Lundberg J, Puddey IB, Woodman RJ, Hodgson JM. Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomised controlled trial. Am J Clin Nutr 102: 368-375, 2015.
Jiang R, Mas E, Hodgson JM, Croft KD, Ward NC. Chlorogenic acid improves ex vivo vessel function and protects endothelial cells against HOCl-induced oxidative damage, via increased production of nitric oxide and induction of Hmox-1. J Nutr Biochem 27: 53-60,2016.
Roles, responsibilities and expertise
Professorial Fellow and Director of the Biomedical Mass Spectrometry facility.
Chair of the Animal Ethics Committee of Royal Perth Hospital. Editor-in Chief of the Royal Society of Chemistry journal Food and Function.
Future research
Dietary polyphenols and cardiovascular risk.
Role of CYP450 metabolites of arachdonic acid in control of endothelial function and blood pressure.
Mechanism of nitric oxide regulation by dietary flavonoids.
Funding received
National Health and Medical Research Council.
National Heart Foundation of Australia.
Australian Research Council Linkage Grants.
Industrial relevance
Food and agricultural products.
Bioassays for new drug development.
Clinical trials.
Australasian Society for Free Radical Research.
Australian Atherosclerosis Society.
Australian Society for Medical Research.
Fellow of the Royal Society of Chemistry
Honours and awards
International Atherosclerosis Society Fellowship
Research Unit coordinator of the MD scholarly activity program
Current external positions
Visiting Professor Kobe University
Current projects
Several projects on bioactive dietary polyphenols in human and mice models. Biomarkers of oxidative stress.
Development of new mass spectrometry based assays.
Research profile
Research profile and publications

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Last updated:
Tuesday, 3 November, 2015 2:39 PM