The University of Western Australia

UWA Staff Profile

Ipsum Lorem

Assoc/Prof Lindy Fitzgerald

Principal Research Fellow
Biological Sciences, School of

Contact details
Address
School of Biological Sciences
The University of Western Australia (M317)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 6488 2353
Fax
+61 8 6488 1029
Email
lindy.fitzgerald@uwa.edu.au
Personal homepage
http://www.uwa.edu.au/people/lindy.fitzgerald
Qualifications
BSc PhD W.Aust.
Publications
Research Articles
1.Griffiths, M. and Keast, D. (1990). The effect of glutamine on murine splenic leukocyte responses to T and B cell mitogens. Immunol. and Cell Biol. 68, 405-408. Impact factor: Not available, Number of citations: 2.
2.Griffiths, M. and Keast, D. (1991). The effects of a leukaemia controlling dose of acivicin on murine splenic lymphocytes in vitro and in vivo. Immunol. and Cell Biol. 69, 395-402. Impact factor: Not available, Number of citations: 21.
3.Griffiths, M., Keast, D., Crawford, G.P.M. and Palmer, NT. (1993). The role of glutamine and glucose analogues in metabolic inhibition of human myeloid leukaemia in vitro. Int. J. Biochem. 25(12), 1749-1755. Impact factor: Not available, Number of citations: 9.
4.Fitzgerald, M., Anderson, K.E. and Woodcock, E.A. (1994) Inositol (1,4,5) trisphosphate [Ins(1,4,5)P3] and Ins(1,4,5)P3 receptor concentrations in heart tissues. Clin. Exp. Pharm. Physiol., 21, 257-260. Impact factor: Not available, Number of citations: 4.
5.Fitzgerald, M., Anderson, K.E. and Woodcock, E.A. (1994) Inositol (1,4,5) trisphosphate receptor function in neonatal cardiomyocytes. European J. Pharmacol., Molecular Pharmacol. Section, 268, 275-278. Impact factor: 2.477, Number of citations: 5.
6.Griffiths, M. and Keast, D. (1994) Fab fragments from the monoclonal antibody ML30 bind to treated human myeloid leukaemia cells. FASEB J. 8, 259-261. Impact factor: 7.064, Number of citations: 7.
7.Fitzgerald, M., Neylon, C.B., Marks, A. and Woodcock, E.A. (1994). Reduced ryanodine receptor content in isolated neonatal cardiomyocytes compared with the intact tissue. J. Mol. Cell. Cardiol. 26, 1261-1265. Impact factor: 3.872, Number of citations: 12.
8.Graham, L.D., Hayward, I.P., Fitzgerald, M., Whitelock, J.M., Bingley, J.A., Campbell, J.H. and Underwood, P.A. (1997) Inhibition of phenotypic modulation, growth, and migration of vascular smooth muscle cells by a guanosine-rich 30-mer phosphorothioate oligodeoxynucleotide. Cell Biol Int. 21(9):585-94. Impact factor: 1.194.
9.Stathakis, P., Fitzgerald, M., Matthias, L.J., Chesterman, C.N. and Hogg P.J. (1997). Generation of angiostatin by reduction and proteolysis of plasmin. J. Biol. Chem. 272, 20641-20645. Impact factor: 5.854, Number of citations: 164.
10.Fitzgerald, M., Hayward, I.P., Thomas, A.C., Campbell, G.R. and Campbell, J.H. (1999). Matrix metalloproteinases can facilitate the heparanase-induced promotion of phenotypic change in vascular smooth muscles. Atherosclerosis. 145(1):97-106. Impact factor: 3.777, Number of citations: 53.
11.Jiang XM, Fitzgerald M, Grant CM, Hogg PJ. (1999) Redox control of exofacial protein thiols/disulfides by protein disulfide isomerase. J Biol Chem. 274(4):2416-23. Impact factor: 5.854, Number of citations: 148.
12.Stathakis P, Lay AJ, Fitzgerald M, Schlieker C, Matthias LJ, Hogg PJ. (1999) Angiostatin formation involves disulfide bond reduction and proteolysis in kringle 5 of plasmin. J Biol Chem. 274(13):8910-6. Impact factor: 5.854, Number of citations: 100.

CAREER DISRUPTION

13.Fitzgerald, M., Nairn, P., Bartlett, C.A., Chung, R.S., West, A.K., Beazley, L.D. (2007). Metallothionein-IIA promotes neurite growth via the megalin receptor. Exp. Brain Res. 183(2): 171-180. Impact factor: 1.959, Number of citations: 39
14.Chung RS, Penkowa M, Dittman J, King CE, Bartlett CA, Hidalgo J, Carrasco J, Dunlop SA, Fitzgerald M, Beazley LD, Vickers J, West AK. (2008). Metallothionein is an injury-dependent, astrocyte-derived promoter of axonal regeneration in the CNS. J Biol Chem. 283(22): 15349-58. Impact factor: 5.808, Number of citations: 95
15.Fitzgerald M, Lukehurst SS, Dunlop SA, Beazley LD, Rodger J. (2008). Neurite responses to ephrin-A5 modulated by BDNF: evidence for TrkB-EphA interactions. BBRC. 374(4): 625-30. Impact Factor: 2.749, Number of citations: 7
16.Fitzgerald, M., Evill, L., Banz, K., Carroll, S., Rodger, J. Mineralocorticoids restore quiescent morphology and reduce VEGF receptor expression in inflamed choroidal endothelial cells in vitro. (2009). Ophthalmic Research. 41: 44-52. Impact factor: 1.010
17.Fitzgerald, M., Bartlett, C.A., Evill, L., Rodger, J., Harvey, A.R. and Dunlop, S.A. (2009) Secondary degeneration of the optic nerve following partial transection: the benefits of lomerizine. Experimental Neurology. 216(1): 219-230. Impact Factor: 3.9 Number of citations: 38
18.Fitzgerald, M, Payne, S.C., Bartlett, C.A., Evill, L., Harvey, A.R. and Dunlop, S.A. (2009) Secondary retinal ganglion cell death and the neuroprotective effects of the calcium channel blocker, lomerizine. IOVS. 50(11): 5456-62. Number of citations: 44
19.Fitzgerald, M*, Bartlett, C.A., Harvey, A.R., Dunlop, S.A*. (2010) Early events of secondary degeneration after partial optic nerve transection: an immunohistochemical study. J. Neurotrauma 27: 439-452, Number of citations: 38 *note equal contribution by these authors
20.Selt, M, Bartlett, C.A., Harvey, A.R., Dunlop, S.A. and Fitzgerald, M. (2010) Restoration of Visual Function after Partial Optic Nerve Injury; a Time Course Study Using the Calcium Channel Blocker Lomerizine. Brain Research Bulletin 81: 467-471. Number of citations: 9
21.Arnall, S., Cheam, L.Y., Smart, C., Rengel, A., Fitzgerald, M., Thivierge, J-P., Rodger, J. (2010) Behavioural Brain Research 209: 109-113
22.Fitzgerald M, Bartlett C.A., Payne S.C., Hart N., Rodger J, Harvey A.R. and Dunlop S.A. (2010) Near Infra-red Light Reduces Oxidative Stress and Preserves Function in CNS Tissue Vulnerable to Secondary Degeneration Following Partial Optic Nerve Transection J Neurotrauma 27: 2107-2119 Number of citations: 26
23.Ho D., Fitzgerald M., Bartlett C.A., Zdyrko B., Luzinov I.A., Dunlop S.A*, and Iyer K.S * (2011) The Effects of Concentration-Dependent Morphology of Self-assembling RADA16 Nanoscaffolds on Mixed Retinal Cultures Nanoscale 3: 907-910. Number of citations: 2
24.Payne S.C., Bartlett C.A., Harvey A.R., Dunlop S.A. and Fitzgerald M. (2011) Chronic swelling and abnormal myelination during secondary degeneration of the optic nerve. J Neurotrauma 28: 1077-88 Number of citations: 12
25.Clemons T, Evans C, Zydrko, B, Luzinov I, Fitzgerald M, Dunlop S, Harvey A, Iyer K.S, Stubbs K. (2011) Multifunctional nanoadditives for the thermodynamic and kinetic stabilization of enzymes Nanoscale 3: 4085-4087
26.Evans CW, Fitzgerald M, Clemons TD, House MJ, Padman BS, Shaw JA, Saunders M, Harvey AR, Zdyrko B, Luzinov IA, Silva GA, Dunlop SA and Iyer KS. (2011) Multimodal analysis of PEI-mediated endocytosis of nanoparticles in neural cells. ACS Nano 5(11): 8640-8648, Number of citations: 33
27.Wells J, Kilburn M.R., Shaw J.A., Bartlett C.A., Harvey A.R., Dunlop, S.A. and Fitzgerald M. (2012) Early in vivo changes in calcium ions, oxidative stress markers and ion channel immunoreactivity following partial injury to a central nervous system tract.
J Neuroscience Research 90: 606-618
28.Harrison J, Bartlett CA, Cowin G, Nicholls PK, Evans CW, Clemons TD, Zdyrko B, Luzinov IA, Harvey AR, Iyer KS, Dunlop SA and Fitzgerald M. (2012) In vivo imaging and biodistribution of multimodal polymeric nanoparticles delivered to the central nervous system. Small 8(10): 1579-89, IF=8.349. Number of citations: 20
29.Evans. C.W., Latter, M.J., Ho, D., Clemons, T.D., Fitzgerald, M, Dunlop, S.A, and Iyer, K.S. (2012) Multimodal and Multifunctional Stealth Block Copolymer Nanospheres for Sustained Drug Delivery. New Journal of Chemistry 36: 1457-62
30.Martin, A.D. , Houlihan, E., Morellini, N., Eggers, P.K, James, E., Stubbs, K.A. , Harvey, A.R., Fitzgerald, M, Raston, C.L., Dunlop, S.A. (2012) Synthesis and Toxicology of p-Phosphonic acid calixarenes and O-Alkylated Analogues as Potential Calixarene-based Phospholipids. ChemPlusChem 77(4): 256-8
31.Eggers, P.K, Becker, T., Melvin, M.K, Boulos, R., James, E., Morellini, N., Harvey, A.R, Dunlop, S.A, Fitzgerald, M, Stubbs, K.A and Raston, C.L. (2012) Composite fluorescent vesicles based on ionic and cationic amphiphilic calix[4]arenes RSC Advances 2: 6250-57
32.Evans, C.W., Viola, H., Ho, D., Hool, L., Dunlop, S.A., Fitzgerald, M., Iyer, K.S. (2012) Nanoparticle-mediated internalisation and release of a calcium channel blocker. RSC Advances 2: 8587-90
33.Dev, S., Toster, J., Prasanna, V., Fitzgerald, M., Iyer, K.S., Raston, C. Suppressing Regrowth of microfluidic generated drug nanocrystals using polyelectrolyte coatings (2013) RSC Advances 3: 695-698.
34.Payne S.C, Bartlett, C.A, Harvey, A.R, Dunlop, S.A, and Fitzgerald, M. (2012) Myelin sheath decompaction, axon swelling and functional loss during chronic secondary degeneration in rat optic nerve Investigative Ophthalmology and Visual Science 138(5): 865-70
35.Payne, S.C., Harvey, A.R., Dunlop, S.A and Fitzgerald, M (2013) Early proliferation does not prevent chronic depletion of oligodendrocyte progenitor cells during secondary degeneration of a CNS white matter tract PLoS ONE 8(6): 1-10 e65710
36.Clemons, T.D, Fitzgerald, M., Dunlop, S.A., Harvey, A.R., Swaminathan Iyer, K, and Stubbs. K.A. (2013) An improved methodology for the spectrophotometric determination of chondroitinase ABC activity New Journal of Chemistry 37, 1944-1949
37.*Szymanski, C*., Chiha, C*., Morellini, N*., Cummins, N., Bartlett, C.A., Savigni, D.L., Payne, S.C., Harvey, A.R., Dunlop, S.A., Fitzgerald, M. (2013) Treating secondary degeneration with 670 nm light: reduced oligodendrocyte reactive oxygen species and paranode lengthening, with preservation of visual function PLoS ONE 8(6) e66448
38.James, E., Eggers, P.K., Harvey, A.R., Dunlop, S.A., Fitzgerald, M., Stubbs, K.A., and Raston, C.L. (2013) Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems Organic & Biomolecular Chemistry 11, 6108-6112
39.*Savigni, D.L.*, O’Hare Doig, R.L.*, Szymanski, C.R., Bartlett, C.A., Lozić, I., Smith, N.M., Fitzgerald, M. (2013) Three Ca2+ channel inhibitors in combination reduce chronic secondary degeneration following neurotrauma Neuropharmacology, 75: 380-390 IF=5.1
DOI: 10.1016/j.neuropharm.2013.07.034
40.Cummins, N., Bartlett, C.A., Archer, M., Bartlett, E., Hemmi, J.M., Harvey, A.R., Dunlop, S.A., Fitzgerald, M. (2013) 670nm irradiation limits changes to mitochondrial ultrastructure in optic nerve vulnerable to secondary degeneration in vivo BMC Neuroscience, 14:98. DOI: 10.1186/1471-2202-14-98
41.Challenor, M., Gong, P., Lorenser, D., Fitzgerald, M., Dunlop, S. A., Sampson, D.D., Iyer, K.S. Iron Oxide-Induced Thermal Effects on Solid State Upconversion Emission in NaYF4:Yb3+,Er3+ Nanocrystals (2013) ACS Applied Materials and Interfaces 5(16):7875-80
42.Lozić, I., Bartlett, C.A., Shaw, J.A., Swaminathan Iyer, K., Dunlop, S.A., Kilburn, M.R. and Fitzgerald, M. Direct quantification of Ca microdomain dynamics in specific cell types of white matter vulnerable to secondary degeneration, using NanoSIMS (2014) Metallomics 6(3): 455-64
43. Fitzgerald, M. Strategies to limit dysmyelination during secondary degeneration following neurotrauma (2014) Neural Regeneration Research 9: 1-4
44.O’Hare Doig, R.L., Bartlett, C.A., Maghzal, G.J., Lam, M., Archer, M., Stocker, R., Fitzgerald, M. Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration (2014) Exp Neurol 261: 136-146
45.Giacci, M.K., Wheeler, L., Lovett, S., Dishington, E., Majda, B., Bartlett, C.A., Thornton, E., Harford-Wright, E., Leonard, A., Vink, R., Harvey, A.R., Provis, J., Dunlop, S.A., * Hart, N.S., * Hodgetts, S., * Natoli, R., * Van Den Heuvel, C., Fitzgerald, M. Differential effects of 670 and 830nm red near infrared irradiation therapy: a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury (2014) PLOS ONE 9(8): 1-15 e104565
46.Challenor, M., Gong, P., Lorenser, D., House, M.J., Woodward, R.C., St. Pierre, T., Fitzgerald, M., Dunlop, S.A., Sampson, D.D., Swaminathan Iyer, K. The Influence of Size/Phase in Multimodality of Co-encapsulated Magnetic Photon-Upconverting Polymeric Nanoparticles (2014) Dalton Transactions 43: 16780-16787 IF 4.09
47.Stephens E.K., Tauran, Y. Coleman, A. and Fitzgerald M. Structural requirements for anti-oxidant activity of calix[n]arenes and their associated anti-bacterial activity (2015) Chem. Comm. 51: 851. IF=6.8
48.*Giacci, M.K., Hart, N.S., Hartz, R.V., Harvey, A.R., Hodgetts, S., Fitzgerald, M. Method for the assessment of effects of a range of wavelengths and intensities of red/near-infrared light therapy on oxidative stress in vitro (2015) JoVE March 21 Issue 97; doi: 10.3791/52221
49.Challenor, M., O’Hare Doig, R., Fuller, P., Giacci, M., Bartlett, C.A., Hool, L. Dunlop, S.A., Iyer, K.S., Rodger, J. and Fitzgerald, M. Prolonged glutamate excitotoxicity increases GluR1 protein but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro. (2015) Biochimie 112: 160-171
50.Meloni, B.P., Milani, D., Edwards, A., Anderton, R., O’Hare Doig, R.L., Fitzgerald, M., and Knuckey, N.W. Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties (2015) Pharmacology and Therapeutics 153: 36-54
51.Lozić, I., Hartz, R.V, Bartlett, C.A., Shaw, J.A., Archer, M, Naidu, P.S.R., Smith, N.M., Dunlop, S.A., Swaminathan Iyer, K., Kilburn, M.R. and Fitzgerald, M. Enabling Dual Targeting of Polymeric Nanoparticles to Macrophages and Astrocytes for Treatment of Neurotrauma. (2016) Biomaterials 75: 58-70
52. Lozić, I., Hartz, R.V, Bartlett, C.A., Shaw, J.A., Archer, M, Naidu, P.S.R., Smith, N.M., Dunlop, S.A., Swaminathan Iyer, K., Kilburn, M.R. and Fitzgerald, M. Characterisation of Polymeric Nanoparticles for Treatment of Partial Injury to the Central Nervous System. (2016) Data in Brief http://dx.doi.org/10.1016/j.dib.2016.02.019
53.Smith, N.M., Gachulincova1, I., Ho, D., Bailey, C., Bartlett, C.A., Norret, M., Murphy, M., Buckley, A., Rigby, P.J., House, M.J., St. Pierre, T., Fitzgerald, M., Iyer, K.S.* & Dunlop, S.A. An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenous Nanoparticles Sci. Rep. 6, 22595; doi: 10.1038/srep22595
54.Ashworth, B.E., Stephens, E., Bartlett, C.A., Serghiou, S., Giacci, M.K., Williams, A., Hart, N.S., Fitzgerald, M. Comparative assessment of phototherapy protocols for reduction of oxidative stress in partially transected spinal cord slices undergoing secondary degeneration (2016) BMC Neuroscience 17, 21
55.Smith, N.M., Ho, D., House, M.J., Dunlop, S.A., Fitzgerald, M. and Iyer, K.S. Poly(glycidyl methacrylate) Coated Dual Mode Upconverting Nanoparticles For Neuronal Cell Imaging (2016) New J Chem. 40 6692-6696
56.Clemons, T., Challenor, M., Fitzgerald, M., Dunlop, S.A., Smith, N. and Iyer, K.S. Balancing surface charges and stealth behavior of nanoparticles using mixed polymer brushes (2016) ACS Macro Lett. 5: 1132−1136
57.Krishnan, V.S., White, Z., McMahon, C.D., Hodgetts, S.I., Fitzgerald, M., Shavlakadze, T., Harvey, A.R. and Grounds, M.D. A neurogenic perspective of sarcopenia: time course study of sciatic nerves from aging mice (2016) J. Neuropath & Experimental Neurol. In Press, accepted April 2016
58.Hart, N.S. and Fitzgerald, M A new perspective on delivery of red-near-infrared light therapy for disorders of the brain (2016) Discovery Medicine. In Press, accepted May 2016
59.Halstrom, A., MacDonald, E., Neil, C., Arendts, G., Fatovich, D. and Fitzgerald, M. Elevation of Oxidative Stress Indicators in Plasma Following Traumatic Brain Injury. J Clin Neurosci. In Press, accepted September 2016
60.O’Hare Doig, R.L., Bartlett, C.A., Smith, N.M., Hodgetts, S.I., Dunlop, S.A., Hool, L. and Fitzgerald, M. Specific combinations of Ca2+ channel inhibitors reduce excessive Ca2+ influx and increase neuronal and glial cell viability Neuroscience. In Press
61.Yates, N.J., Giacci, M.K., O’Hare Doig, R.L., Chiha, W., Ashworth, B.E., Kenna, J., Bartlett, C.A. and Fitzgerald, M. The effects of delaying treatment of secondary degeneration using a combination of Ca2+ channel inhibitors: possible confounding effects of seromas. Neural Regeneration Research. In Press

Reviews
62.O’Hare Doig, R.L and Fitzgerald, M. Novel combinations of ion channel inhibitors for treatment of neurotrauma (2015) Discovery Medicine 19(102): 41-47
63.Fitzgerald, M., Hodgetts, S., Van Den Heuvel, C., Natoli, R., Hart, N.S., Valter, K., Harvey, A.R., Vink, B., Provis, J., and Dunlop, S.A. (2013) Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders Reviews in the Neurosciences 24(2): p205-26
64.Fitzgerald, M. The complex contribution of the astrocyte scar (2016) Neural Regeneration Research. 11(7): 1052–1053
65.Fehily, B. and Fitzgerald, M. (2016) Cell Transplantation. Invited review In Press, accepted July 2016

Book Chapter
66.Eells, J.T., Gopalakrishnan, S., Salzman, M., Valter, K., Provis, J., Natoli, R., Mitrofanis, J., Stone, J. and Fitzgerald, M. Low Level Light Therapy (LLLT) for the Treatment of Injury and Disease in the Visual System (2016) In Press: Handbook of Low Level Laser Therapy Eds - Hamblin, M.R., Agrawal, T. and de Sousa, M. Publisher - Pan Stanford Publishing, Singapore.

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Tuesday, 3 November, 2015 2:39 PM