The University of Western Australia

UWA Staff Profile

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Matthew Linden

Assoc/Prof Matthew Linden

Associate Professor
Pathology and Laboratory Medicine

Contact details
Pathology and Laboratory Medicine
The University of Western Australia (M504)
35 Stirling Highway
+61 8 6457 1050
PhD W.Aust.
After earning his PhD in haematology at The University of Western Australia in 2003, Matthew undertook a prestigious postdoctoral fellowship and then junior faculty research position at The Centre for Platelet Function Studies at The University of Massachusetts Medical School, which became The Centre for Platelet Research at Harvard Medical School. Matthew returned to Australia in 2007 as a senior academic at RMIT University's School of Medical Sciences. He returned to the University of Western Australia as Associate Professor and Head of Cytometry in the Centre for Microscopy, Chatacterisation and Analysis in 2012, before joining the School of Pathology and Laboratory Medicine (now the School of Biomedical Sciences) as Associate Professor of Haematology in 2015.
Key research
Matthew's research focus is in the study of blood platelets. His research has three key themes. His contribution to the understanding of mechanisms of underlying platelet hyper-reactivity and its relationship to antiplatelet therapy resistance has improved the diagnosis and management of this condition. Through broad collaborations, Matthew has led the development of new antiplatelet therapies with novel therapeutic targets. Finally, Matthew has begun to unravel the role of platelets in immunity and aging, particularly through their interactions with blood monocytes and neutrophils.
Google Scholar Profile:

10 most recent of 104 Scholar entries

Haynes A, Linden MD, et al. Acute impact of conventional and eccentric cycling on platelet and vascular function in patients with chronic heart failure. J App Physiol 2017;122(6),1418-24.

Cerezo MI, Linden MD, Agusti S. Flow cytometry detection of planktonic cells with polycyclic aromatic hydrocarbons sorbed to cell surfaces. Marine Pollution Bulletin 2017;118(1),64-70

Haynes A, Linden MD, et al. Relationship between monocyte‐platelet aggregation and endothelial function in middle‐aged and elderly adults. Physiol Rep 2017;5(10),e13189.

Hui H, Fuller KA, Erber WN, Linden MD. Imaging flow cytometry in the assessment of leukocyte-platelet aggregates. Methods 2017;112,46-54.

Haynes A, Linden MD, et al. Impact of commonly prescribed exercise interventions on platelet activation in physically inactive and overweight men. Physiol Rep 2016;4(20),e12951.

Fuller K, Linden MD, et al. An active, collaborative approach to learning skills in flow cytometry. Adv Physiol Educ 2016;40(2),176-85.

Burchall GF, Piva T, Linden MD, et al. Comprehensive assessment of the hemostatic system in polycystic ovarian syndrome. Semin Thromb Haemost 2016;42(1),55-62.

Kekäläinen J, Larma I, Linden MD, Evans JP. Lectin staining and flow cytometry reveals female-induced sperm acrosome reaction and surface carbohydrate reorganization. Nat Sci Rep 2015;5,15321.

Yip C, Linden MD, et al. Platelets from children are hyper‐responsive to activation by thrombin receptor activator peptide and adenosine diphosphate compared to platelets from adults. Br J Haem. 2015;168(4),526-32.

Cini C, Yip C, Attard C, Karlaftis V, Monagle P, Linden MD, Ignjatovic V. Differences in the resting platelet proteome and platelet releasate between healthy children and adults. J Proteom 2015;123,78-88.
Roles, responsibilities and expertise
Matthew is Associate Professor of Haematology at The School Biomedical Sciences. He leads the development and delivery of haematology coursework in the Master of Clinical Pathology, supports undergraduate teaching in the Bachelor of Science (Pathology and Laboratory Medicine Major), and forms part of the School's research program in haematology. Matthew also leads a program of research which focuses on the role of platelets and platelet interactions in health and disease.
Funding received
2016 NHMRC Project Grant (APP1129317 CIF) $1,113,385
2016 Australian Research Council Discovery Project (DP170104832 CIC) $372,500
2014 Australian Research Council LIEF (LE150100066 CIE) $440,000
2014 WA Department of Health (CIA) $75,000
2014 Ada Bartholomew Trust (CIA) $28,471
2013 Perpetual Trustees & Ronald Geoffrey Arnott Foundation (CIA) $65,000
2013 The Ian Potter Foundation (CIA) $25,000
2013 NHMRC Equipment Allocation (CIA) $50,000
2012 Diabetes Australia Research Trust (CIA) $58,407.
2011 Helen McPherson Research Trust (CIC) $24,700.
2011 RMIT University Scheme for Teaching and Learning Research (CIC) $6,924.
2010 Carlton Football Club (CIB) $25,255.
2009 Ian Potter Foundation (CIA) $100,000.
Industrial relevance
Matthew works closely with biopharmaceutical industry partners in the development of new antiplatelet therapies with novel therapeutic targets, and to characterise the effect of other investigational agents on platelet function. He also works closely with industry partners in the development of new laboratory methods for the assessment of platelet function and monitoring the effectiveness of antiplatelet therapy.
American Heart Association Council on Atherosclerosis, Thrombosis and Vascular Biology.
International Society for the Advancement of Cytometry
American Society of Hematology
International Society on Thrombosis and Haemostasis
Australasian Cytometry Society (Chair, 2015 conference organising committee)
Honours and awards
2017 UWA Student Guild "Student's Choice" Teaching Award - Health & Medical Sciences
2016 ISAC Marylou Ingram Scholar
2016 UWA FMDHS Teaching Award (Nominee)
2011 RMIT College of Science, Engineering and Health Teaching Award (Student Choice)
2011 RMIT School of Medical Sciences Good Teaching Award
2011 RMIT School of Medical Sciences Grant Success Recognition Award
2010 RMIT College of Science, Engineering and Health Teaching Excellence Award
2010 RMIT School of Medical Sciences Good Teaching Award
2010 RMIT School of Medical Sciences Grant Success Recognition Award
2008 RMIT University Emerging Researcher Award
Previous positions
2012 - 2015 Associate Professor and Head (Cytometry), University of Western Australia
2008 - 2012 Senior Lecturer and Director of Flow Cytometry, RMIT University
2007 - 2008 Research Officer, RMIT University School of Medical Sciences
2005 - 2007 Research Instructor, University of Massachusetts Medical School Department of Emergency Medicine
2003 - 2007 Postdoctoral Fellow, University of Masscahusetts, Department of Pediatrics
PATH5161 - Unit Coordinator
PATH5162 - Unit Coordinator
PATH5142 - Laboratory
PATH5122, IMED2002, PATH3307, MICR5831 - Lectures
Current external positions
Monash University Department of Epidemiology and Preventative Medicine (Honoary Adjunct Senior Lecturer)
Current projects
Treasurer, CYTO Asia Organising Committee
Chair, "WA Flow" The Western Australian Flow Cytometry Interest Group.
Research profile
Research profile and publications

The University of Western Australia

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Last updated:
Tuesday, 3 November, 2015 2:39 PM