The University of Western Australia

UWA Staff Profile

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Michael Paech

Professor Michael Paech

Chair of Obstetric Anaesthesia
Medicine and Pharmacology, School of, Pharmacology, Pharmacy and Anaesthesiology Unit

Contact details
Address
School of Medicine and Pharmacology - Pharmacology, Pharmacy and Anaesthesiology Unit
The University of Western Australia (M510)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 9340 2200
Email
michael.paech@health.wa.gov.au
Qualifications
MB BS Adel., DM W.Aust., DA, DRCOG, FRCA, FANZCA, FFPMANZCA, FRANZCOG
Biography
Professor Mike Paech has a Chair of Obstetric Anaesthesia in the Pharmacology and Anaesthesiology Unit of the School of Medicine and Pharmacology, the University of Western Australia. He trained in South Australia and the UK and has longstanding interests in obstetric anaesthesia, pain medicine, undergraduate and postgraduate teaching and clinical research, having directed departmental research at Royal Perth and King Edward Memorial Hospitals.
He is an editor of the journal Anaesthesia and Intensive Care and on the editorial boards of several journals, including two international obstetric anaesthesia journals. He has represented the Australian and New Zealand College of Anaesthetists as a member of the Research, Examinations and WA Regional Committees, chair and executive member of the Obstetric Anaesthesia Special Interest Group, scientific co-convenor of the ANZCA Annual Scientific Congress 2012, various working parties and the National Advisory Committee on Maternal Mortality. He has represented the Australian Society of Anaesthetists on the National Scientific Congress sub-committee and was scientific program convenor for the 2007 annual congress; and on the World Federation of Societies of Anaesthesiology Obstetric Committee. He is a past-President of the Asian and Oceanic Society of Regional Anaesthesia and Pain Medicine.

Key research
Research interests are predominantly in clinical anaesthesia and analgesia, with a focus on clinical pharmacology but including applied basic research. Research at King Edward Memorial Hospital for Women relates especially to regional (spinal and epidural) anaesthesia during pregnancy and to acute pain management, with special interests in the application of patient-controlled epidural analgesia and innovative drug delivery technologies; the efficacy and safety of intraspinal analgesic drugs; the complications of central neural block; consumer satisfaction; and the pharmacology of drugs administered during lactation (in collaboration with Emeritus Professor Ken Ilett).
Other research areas of interest (also at Royal Perth Hosiptal) include day-care anaesthesia, postoperative pain relief and perioperative outcome, for example the impact of anaesthesia on postoperative morbidity and the prevention of postoperative nausea and vomiting. Collaborations exist with the Australian and New Zealand College of Anaesthetists Trials Group and with colleagues in Australasia and overseas.
Publications
Books (n=2)Handbook of Obstetric Anesthesia. Palmer C, D’Angelo R, Paech M (eds) 2002 Bios Publishers, Oxford

Obstetric Anesthesia Palmer C, D’Angelo R, Paech M (eds). Oxford University Press, New York (2011)
Book Chapters & Gazetted Materials (n=15)

Review Articles, Clinical Practice Guidelines and Editorials (n=37)
Book Chapters (n=17)
Peer-reviewed Journal Articles (n=136)
Lettersand post-publication reviews(n=27)
Last 12-

Leslie K, Myles PS, Chan MT, Forbes A, Paech MJ, Peyton P, Silbert BS, Williamson E. Nitrous oxide and long-term morbidity and mortality in the ENIGMA Trial. Anesth Analg 2011;112:387-393 PubMed PMID:20861416.

Sinha A, Paech MJ, Thew ME, Rhodes M, Luscombe K, Nathan E. A randomised, double-blinded, placebo-controlled study of acupressure wristbands for the prevention of nausea and vomiting during labour and delivery. Int J Obstet Anesth 2011;20:110-117 PubMed PMID: 21194921.

Al-Tamimi Y, Ilett KF, Paech MJ, O’Halloran SJ, Hartmann PE. Estimation of infant dose and exposure to pethidine and norpethidine via breast milk following patient-controlled epidural pethidine for analgesia post caesarean delivery. Int J Obstet Anesth 2011;20:128-134

Salmon S, Sy SKB, Ilett KF, Page-Sharp M, Paech MJ. Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk. Euro J Clin Pharm 2011;67:899-908 PubMed PMID:21394525.

Paech MJ, Doherty DA, Christmas T, Wong CA; Epidural Blood Patch Trial Group. The volume of blood for epidural blood patch in obstetrics: A randomized, blinded clinical trial. Anesth Analg 2011;113:126-133 PubMed PMID: 21596867.

Hillyard SG, Bate TE, Corcoran TB, Paech MJ, O'Sullivan G. Extending epidural analgesia for emergency Caesarean section: a meta-analysis. Br J Anaesth 2011;107:668-678. PubMed PMID: 21997149.

Barden AE, Corcoran TB, Mas E, Durand T, Galano JM, Roberts LJ, Paech M,Muchatuta NA, Phillips M, Mori TA. Is there a role for isofurans and
neuroprostanes in pre-eclampsia and normal pregnancy? Antioxid Redox Signal 2012;16:165-169.PubMed PMID: 21827297.

Leslie K, Myles PS, Halliwell R, Paech MJ, Short TG, Walker S. Beta-blocker management in high-risk patients presenting for non-cardiac surgery: before and after the POISE Trial. Anaesth Intensive Care 2012;40:319-327

Paech MJ, Salman S, Ilett KF, O’Halloran SJ, Muchatuta NA. Infant dose and exposure to parecoxib and its primary active metabolite valdecoxib via transitional breastmilk following intravenous parecoxib use after cesarean delivery. Anesth Analg 2012;114:837-844

Schug S, Lim CB, Sunderland B, Paech MJ, Liu Y. A phase I pharmacokinetic and bioavailability study of a sublingual fentanyl wafer in healthy volunteers. Anesth Analg 2012:115;554-9

Sakalidis VS, Williams TM, Hepworth AR, Garbin CP, Hartmann PE, Paech MJ, Al-Tamimi Y, Geddes DT. A comparison of early sucking dynamics during breastfeeding after cesarean section and vaginal birth. Breastfeeding Med 2012 DOI: 10.1089/bfm.2012.0018
Roles, responsibilities and expertise
With colleagues Professor Stephan Schug and Professor Thomas Ledowski I am responsible for undergraduate teaching and training of 4th, 5th and 6th year medical students. I mentor medical students and supervise several higher degree students. I am actively involved in the Australian and New Zealand College of Anaesthetists postgraduate training in areas such as teaching and training; simulation; curriculum development and assessment. I am frequently called on to teach at local, national and international meetings and scientific congresses. I peer-review for more than 35 medical journals, and am an editor of the Australasian anaesthetic journal. I have chaired international obstetric and regional anaesthesia groups and been a member of other similar organisations.
My research responsibilities include directorship of a small but active research team based at King Edward Memorial Hospital for Women and in the past a similar role at Royal Perth Hospital. I have been on several hospital research and ethics committees and am a long-standing member of the College of Anaesthetists Research and Trials Committees.
My clinical expertise lies in anaesthesia and analgesia for the pregnant woman and in acute pain management. I am viewed as an international expert in specific topics within these fields of practice.
Future research
My current and planned research trials are:

Nitrous oxide anaesthesia and cardiac events after major surgery (ENIGMA II)
The influence of antiemetic doses of dexamethasone on postoperative lymphocyte sub-populations after abdominal surgery
A non-inferirity trial of metaraminol and phenylephrine to prevent hypotension at spinal anaesthesia for caesarean section
Wellbeing after intervention with neostigmine and glycopyrrolate or sugammadex: a randomised trial (the WINGS study)
Methylnaltrexone to prevent intrathecal morphine-induced pruritus after caesarean delivery: a randomised clinical trial. (The MEAN ITCH Trial)
POISE-2: A large, international, placebo-controlled, factorial trial to assess the
impact of clonidine and aspirin in patients undergoing noncardiac surgery who are
at risk of a perioperative cardiovascular event
Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery (The RELIEF Trial)
Funding received
In total I have attracted research grant funding to the tune of several million dollars.
My grants in the past 5 years are listed -

The Australian Society of Anaesthetists / Abbott Australia 2008
Comparison of the EpiSure™ Autodetect™ syringe with the Portex loss-of-resistance syringe: a randomised controlled trial
$40,000

Women and Infants Research Foundation 2008
Epidural Pethidine after Caesarean Section. A Pilot Study of Initiation of lactation, Plasma and Milk Levels of Pethidine and Norpethidine and the Behaviour of Breast-fed Infants (The EPACS Study)
$15,000

Women and Infants Research Foundation 2008
Determination of equipotent infusion doses of metaraminol and phenylephrine to prevent hypotension at spinal anaesthesia for caesarean section
$13,000

Pfizer Pharmaceuticals Investigator-initiated grant 2009
Celecoxib, paracetamol or their combination for analgesia after caesarean section
$35,844
Neurotrauma Research Program (NRP)2009
Neuroprostanes Reflect Ongoing Neurological Injury
$89,944.

Western Australian Department of Health (SHRAC)2009
Electronic support systems for preoperative assessment and management – improved quality and reduced cost
$150,000

The Jackson Rees Research Grant, Australian Society of Anaesthetists 2009
Pre-Epidural Rapid Ultra Sound Assessment of Anatomical Landmarks, Observational Pilot Study
$15,000

Australian and New Zealand College of Anaesthetists 2009
Determination of equipotent infusion doses of metaraminol and phenylephrine to prevent hypotension at spinal anaesthesia for caesarean section
$10,000

National Health & Medical Research Council of Australia 2011-15
POISE-2: A large, international, placebo-controlled, factorial trial to assess the
impact of clonidine and aspirin in patients undergoing noncardiac surgery who are
at risk of a perioperative cardiovascular event
$1,136,310

Australian and New Zealand College of Anaesthetists 2012
Methylnaltrexone to prevent intrathecal morphine-induced pruritus after caesarean delivery: a randomised clinical trial. (The MEAN ITCH Trial)
$40,273
Industrial relevance
I am involved in research of innovative approaches to analgesic drug delivery although to date this has not been commercialised. I have been or am a consultant to a number of pharmaceutical and medical equipment companies.
Languages
I am English speaking only.
Memberships
Australian and New Zealand College of Anaesthetists1986-

Faculty of Pain Medicine, Australian and New Zealand College of Anaesthetists1999-

Australian Society of Anaesthetists1988-

Society of Obstetric Anesthesia and Perinatology1996-

Perinatal Society of Australian and New Zealand1998-

Obstetric Anaesthetists’ Association2005-

Australian Medical Association1998-

Society of Obstetric Medicine of Austalia and New Zealand2004-

Asian and Oceanic Society of Regional Anaesthesia and Pain Medicine1999-
Honours and awards
The Boots / Australian Society of Anaesthetists Young Investigator Award 1988

The Dr. John Boyd Craig / College of Anaesthetists Annual Award1991 &2003

Honorary Research Fellow, Women and Infants Research Foundation, WA1996-

The Australian Society of Anaesthetists “Australasian Visitor”
and the 2nd Kester Brown Lecturer, Dunedin NZ 1998

Clinical Associate Professor, University of Western Australia 1999-

Honorary Fellowship of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists 2006

Lennard Travers Professor, ANZCA 2007

Magill Lecturer, Imperial College London 2010

Mundipharma ANZCA Research Award 2012
Previous positions
Visiting Specialist Anaesthetist
Royal Perth Hospital, Perth, Western Australia 2000-

Head, Department of Anaesthesia
King Edward Memorial Hospital for Women, Perth, Western Australia 1993-1996

Staff Specialist Anaesthetist
King Edward Memorial Hospital for Women, Perth, Western Australia 1988-2002

Part-time Clinical Lecturer in Anaesthesia
Department of Surgery, University of Western Australia 1988-1999

Staff Specialist Anaesthetist
National Womens' and Auckland Hospitals, Auckland, New Zealand 1986-87
Patents
Nil
Teaching
The topics I am most frequently asked to teach are: any aspect of obstetric anaesthesia; pain relief in labour and pregnancy; postoperative pain relief; complications of epidural and spinal anaesthesia; intraspinal analgesics; management of obstetric haemorrhage and preeclampsia; postoperative nausea and vomiting; anaesthesia and perioperative outcome and clinical research.
Current external positions
Nil
New and noteworthy
My latest textbook was publsihed in 2011. New NHMRC funding has been received for 2013-2015 and I have joined the ANZCA new training curriculum Scholar Role Committee. Invited speaker invitations in 2013 are to congresses in Sydney, England and Malaysia.
Current projects
A number of research trials and book chapters.
Research profile
Research profile and publications
 

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Tuesday, 3 November, 2015 2:39 PM

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