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Ipsum Lorem

Ming-Hao Zheng

Professor Ming-Hao Zheng

Associate Dean (International)
Health and Medical Sciences, Faculty of

Contact details
Address
Faculty of Health and Medical Sciences
The University of Western Australia (M508)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 6457 3213
Fax
+61 8 6457 3210
Email
minghao.zheng@uwa.edu.au

Professor
Surgery

Contact details
Address
Surgery
The University of Western Australia (M508)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 6457 4050
Fax
+61 8 6457 3210
Email
minghao.zheng@uwa.edu.au
Qualifications
MB BS Shantou, DM PhD W.Aust., FRCP, ARCPA
Biography
Prof. Ming-Hao Zheng is the Winthrop Professor and Director of Research at the Translational Orthopaedic Research Centre, Sir Charles Gairdner Hospital, Perth and the Associate Dean (International) of the Faculty of Medicine, Dentistry and Health Sciences, the University of Western Australia. He is also the Chung Kong Scholar Lecturing Professor and the Deputy Director of Australia-China Cooperative Research Centre for Biotherapeutics and Regenerative Medicine at the Zhejiang University, China, Director for UWA-Nanjing Bone and Joint Research Centre at Nanjing University. He has served on the editorial board member for numbers of Orthopaedics, stem cell and Pathology journals.
He has focused on the development of an academic career in bone and joint research and regenerative medicine. His productivity is evidenced by the quality of publications and patents, and his ability to transform laboratory research into clinical practice. He has published over 140 peer-reviewed papers in journals including Nature Medicine, Annals of Internal Medicine, Journal of Clinical Investigation, Molecular Cellular Biology, Journal of Biological Chemistry, American Journal of Pathology and Journal of Bone and Mineral Research.
His major achievements include studies in the molecular and cellular biology of the osteoclast, clinical and laboratory evaluation of cellular therapies, human bone allograft, development of cell-scaffold technology for cartilage, tendon and bone regeneration and regulatory framework in human tissue and cellular products. His work on Giant Cell Tumour of bone (GCT) has been used by WHO for classification of bone tumours and has been recorded in the textbook “Ackermans Surgical Pathology”.
He has 7 patents in the field of Orthopaedics and has introduced the concept and technology of autologous biotherapy in orthopaedics. His research results in the development of autologous stem cell and progenitor cell therapy in bone, cartilage and tendon. He has transformed the benchwork of Matrix-induced Autologous Chondrocyte Implantation (MACI) and Autologous Tencoyte Therapy (ATT) into clinical practices. In 2009, he received an honour from by Genzyme in Boston for his leadership, commitment and dedication to the advancement of MACI. To date, more than 120 hospitals across Australia and over 8000 patients in the world have used MACI for the treatment of cartilage defects.
Prof. Zheng has actively supervised and nursed quality postgraduate students and postdoctoral fellows with 24 PhD and 15 Master of Medical sciences students completing their degree in the last 15 years. Many of them have won awards at the national and international meetings for their research work and become high profile independent researchers.
Key research
Molecular and cellular biology of the osteoclast, with focus on interacellular vesicle trafficking and V-ATPase;
Clinical trials and laboratory evaluation of cellular therapies in orthopaedics;
Human bone allograft –validation and process characterisation;
Development of cell-scaffold technology for cartilage, tendon and bone regeneration
Development of bioreactors for mechanical sense tissues
Publications
Top 10 publications
1)Wang T, Lin Z, Day RE, Gardiner B, Landao-Bassonga E, Rubenson J, Kirk TB, Smith DW, Lloyd DG, Hardisty G, Wang A, Zheng Q, Zheng MH. Programmable mechanical stimulation influences tendon homeostasis in a bioreactor system. Biotechnol Bioeng. 2013 May;110(5):1495-507. (Recommended to Faculty 1000).
2)Ng PY, Cheng TS, Zhao H, Ye S, Sm Ang E, Khor EC, Feng HT, Xu J, Zheng MH, Pavlos NJ. Disruption of the dynein-dynactin complex unveils motor-specific functions in osteoclast formation and bone resorption. J Bone Miner Res. 2013 Jan;28(1):119-34.(cover page)
3)Qin A, Cheng TS, Lin Z, Pavlos NJ, Jiang Q, Xu J, Dai KR, Zheng MH, (2011) Versatile Roles of V-ATPases Accessory Subunit Ac45 in Osteoclast Formation and Function. PLoS One Vol 6 (11) e27155.
4)Mackie KE, Zhou Z, Robbins P, Bulsara M, Zheng MH (2011) Histopathology of Femoral Head Donations: A Retrospective Review of 6161 Cases. J Bone Joing Surg Am. 93:1500-9.(recommended to Faculty 1000).
5)Chen J, Yu Q, Wu B, Pavlos N, Xu J, Ouyang H, Wang A, Zheng MH, (2011) Autologous Tenocyte Therapy for Experimental Achilles Tendinopathy in a Rabbit Model. Tissue Engineering Part A. (cover page).
6) Pavlos NJ, Cheng TS, Qin A, Ng PY, Feng HT, Ang ESM, Carrello A, Sung CH, Jahn R, Zheng MH, Xu J. (2011) Tctex-1, A novel interaction partner of RAB3D is required for osteoclastic bone resorption. Molecular Cellular Biology. Molecular and Cellular Biology, 25:1551-1564.7 (15-16):2037-48.
7)Qian Y, Lin Z, Chen J, Fan Y, Davey T, Cake M, Day R, Dai K, Xu J, Zheng MH (2009) Natural bone collagen scaffold combined with autologous enriched bone marrow cells for induction of osteogenesis in an ovine spinal fusion model. Tissue Eng Part A. 15(11):3547-58.
8)Feng H, Cheng T, Steer JH, Joyce DA, Pavlos NJ, Leong C, Kular J, Liu J, Feng X, Zheng MH, Xu J (2009) Myocyte enhancer factor 2 and microphthalmia-associated transcription factor cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis. J Biol Chem. 2009, 22;284(21):14667-76.
9)Yao F, Seed C, Wood D, Zheng MH (2008) Prevalence and Incidence of Viral Infections Among Musculoskeletal Tissue and First-Time Blood. Annals of Internal Medicine 148:792-794
10)Zheng MH, Willers C, Kirilak L, Yates P, Xu J, Wood D, Shimmin A (2007) Matrix-Induced Autologous Chondrocyte Implantation (MACI ): Biological and Histological Assessment. Tissue Engineering 13 (4): 737-746.
Research profile
Research profile and publications
 

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Last updated:
Tuesday, 3 November, 2015 2:39 PM