The University of Western Australia

UWA Staff Profile

Ipsum Lorem

Nathan Pavlos

Assoc/Prof Nathan Pavlos

Associate Professor
Orthopaedic Research Unit

Contact details
Address
Orthopaedic Research Unit
The University of Western Australia (M508)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 6457 2083
Fax
+61 8 6457 3210
Email
nathan.pavlos@uwa.edu.au
Qualifications
BSc PhD W.Aust.
Biography
Dr Nathan Pavlos is currently an Associate Professor and Head of the Cellular Orthopaedics Laboratory at the Centre for Orthopaedic Research, School of Surgery at the University of Western Austrlia. He completed his undergraduate and PhD studies at UWA. In 2007 Dr Pavlos was awarded a NHMRC CJ Martin (Biomedical) Overseas Research Fellowship and carried out his postdoctoral training at the Max-Planck-Institute (MPI) for Biophysical Chemistry, Germany, from 2007-2009 with Prof Reinhard Jahn where he worked on membrane trafficking. In 2010 Dr Pavlos returned to UWA to start up his own laboratory within the Centre of Orthopaedic Research.
Key research
Dr Pavlos’s current research interest focuses on deciphering core molecular machinery of bone-resorbing osteoclasts, the major cellular protagonists underlying a number of highly debilitating orthopaedic-related diseases including osteoporosis, Paget's disease and tumour-mediated bone loss. To achieve this, he employs several high-through-put screens for candidate components of the osteoclastic resorptive machinery including integrative genomic, quantitative proteomic and phenomic screens. Along with his focus on osteoclasts and bone biology, he also have a long-standing interest into the molecular mechanisms regulating intracellular membrane trafficking.
Publications
i)Original Peer Reviewed Articles:
1.Ang ESM, Pavlos NJ, Chim SM, Feng HT, Scaife RM, Steer J, Zheng MH and Xu J. Paclitaxel inhibits osteoclast formation and bone resorption via influencing mitotic cell cycle arrest and RANKL-induced activation of NF-κB and ERK. J Cell Biochem (Accepted Oct 17) (2011)

2.Ye S, Fowler TW, Pavlos NJ, Ng PY, Feng Y, Zheng MH, Manolagas SC and Zhao H. LIS1 Regulates Osteoclast Formation and Function through Its Interactions with Dynein/Dynactin and Plekhm1 PLoS One (Accepted Oct 13) (2011)

3.Qin A*, Cheng TS*, Lin Z, Pavlos NJ, Jiang Q, Xu J, Dai KR and Zheng MH. Versatile roles of V-ATPase accessory subunit Ac45 in osteoclast formation and function. PLoS One (Accepted Oct 11) (2011)

4.Lin Z, Solomon KL, Zhang X, Pavlos NJ, Abel T, Willers C, Dai K, Xu J, Zheng Q, Zheng M. In vitro evaluation of natural marine sponge collagen as a scaffold for bone tissue engineering, Int J Biol Sci. 7(7):968-77 (2011)

5.Hodge JM, Collier FM, Pavlos NJ, Kirkland MA and Nicholson GC, M-CSF Potently Augments RANKL-Induced Resorption Activation in Mature Human Osteoclasts. PLoS One 6 (6):e21462. Epub Jun 29 (2011)

6. Chim SM, Qin A, Tickner J, Pavlos NJ, Davey T, Wang H, Guo Y, Zheng MH and Xu J. EGFL6 promotes endothelial cell migration and angiogenesis through the activation of ERK J Biol Chem, Epub April 29 (2011)

7.Chen J, Qian Y, Wu B, Pavlos NJ, Xu J, Ouyang H, Wang A and Zheng MH. Autologous Tenocyte therapy for Experimental Achilles Tendinopathy in a Rabbit Model. Tissue Eng Part A, Epub April 15 (2011)

8. Pavlos NJ, Cheng TS, Qin A, Ng PY, Feng HT, Ang ES, Carello A, Sung CH, Jahn R, Zheng MH and Xu J. Tctex-1, a Novel Interaction Partner of Rab3d, Is Required for Osteoclastic Bone Resorption. Mol Cell Biol 31(7):1551-64. Epub Jan 24 (2011)
9. Pavlos NJ, Gronborg M, Riedel D, Chua JJ, Boyken J, Kloepper TH, Urlaub H, Rizzoli SO and Jahn R.Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. J Neurosci 30:13441-53 (2010)

10. Grønborg M, Pavlos NJ, Brunk I, Chua JE, Münster- Wandowski, A, Riedel D, Ahnert-Hilger G, Urlaub H and Reinhard Jahn, Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein J Neurosci 6;30(1):2-12 (2010)

11. Feng H, Cheng T, Steer JH, Joyce DA, Pavlos NJ, Leong C, Kular J, Liu J, Feng X, Zheng MH, Xu J Myocyte enhancer factor 2 and microphthalmia-associated transcription factor cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis. J Biol Chem 284:14667-14676 (2009)

12. Pavlos NJ*, Cheng T*, Wang C, Tan JW, Lin JM, Cornish J, Zheng MH, Xu J. Mutations within the TNF-like core domain of RANKL impair osteoclast differentiation and activation. Mol Endocrinol 23:35-46 (2009) (*Equal contribution)

13. Ang ES, Pavlos NJ, Chai LY, Qi M, Cheng TS, Steer JH, Joyce DA, Zheng MH, Xu J. Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL-induced NF-kappaB and NFAT activity. J Cell Physiol 221:642-649 (2009)

14. Ang E, Pavlos NJ, Rea SL, Qi M, Chai T, Walsh JP, Ratajczak T, Zheng MH, Xu J. Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades. J Cell Physiol 220:450-459 (2009)

15. Feng H*, Cheng T*, Pavlos NJ, Yip KH, Carrello A, Seeber R, Eidne K, Zheng MH, Xu J. Cytoplasmic terminus of vacuolar type proton pump accessory subunit Ac45 is required for proper interaction with V(0) domain subunits and efficient osteoclastic bone resorption. J Biol Chem 283:13194-13204 (2008) (Equal contribution)

16.Zhen L, Pavlos NJ, Cake MA, Wood DJ, Xu J, Zheng MH. Evidence that human cartilage and chondrocyte do not express calcitonin receptor. Osteoarthritis and Cartilage, (2007)

17. Zheng MH, Hinterkeuser K, Solomon K, Kunert V, Pavlos NJ and Xu J. Collagen-Derived Biomaterials in Bone and Cartilage Repair Macromol Symp 253, 179–185 (2007)

18. Yip KHM, Feng H, Pavlos NJ, Zheng MH, Xu J. p62 UBA domain mediated RANKL-induced osteoclast formation: a new insight into the pathogenesis of Paget’s disease of bone. Am J Path 169(2):503-14 (2006)

19. Partsalis T, Chan LYS, Hurworth M, Willers C, Pavlos N, Kumta N, Wood D, Xu J, Kumta S, Lo YMD, Zheng MH. Evidence of circulating donor genetic material in bone allotransplantation. Int J Mol Med 17(6):1151-5 (2006)

20.Pavlos NJ*, Laird RK*, Xu J, Brankov B, White B, Fan Y, Papadimitriou JM,Wood DJ, Zheng MH. Bone Allograft Non-Union is Related to Excessive Osteoclastic Bone Resorption: A Sheep Model Study. Histo Histopathol 21(12):1277-85 (2006) (*equal contributor)

21.Pavlos NJ*, Kirilak* Y, Willers CR, Han R, Feng H, Xu J, Asokananthan N,Stewart GA, Henry P, Wood D, Zheng MH. Fibrin sealant promotes migration and proliferation of human articular chondrocytes: possible involvement of thrombin and protease-activated receptors. Int J Mol Med 17(4):551-8 (2006) (*equal contributor)

22. Pavlos NJ, Xu J, Riedel D, Yeoh SG, Teitelbaum SL, Papadimitriou JM, Jahn R, Ross FP, Zheng MH. Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption. Mol Cell Biol 25(12):5253-69 (2005)

23. Xu J, Wang, C, Han R, Pavlos NJ, Phan T, Steer JH, Bakker AJ, Joyce DA, Zheng MH. Evidence of reciprocal regulation between the high extracellular calcium and RANKL signal transduction pathways in RAW cell derived osteoclasts. J Cell Physiol 202(2):554-562 (2005).

24. Xu J, Feng HT, Wang C, Yip KH, Pavlos NJ, Papadimitriou JM, Wood D, Zheng MH. Effects of Bafilomycin A1: An inhibitor of vacuolar H (+)-ATPases on endocytosis and apoptosis in RAW cells and RAW cell-derived osteoclasts. J Cell Biochem 88:1256-64 (2003)

25. Liu D, Xu JK, Figliomeni L, Huang L, Pavlos NJ, Rogers M, Tan A, Price P, Zheng MH. Expression of RANKL and OPG mRNA in periodontal disease: Possible involvement in bone destruction. Int J Mol Med 11:17-21 (2003)

26. Pavlos NJ, Xu J, Papadimitriou JM, Zheng MH. Molecular cloning of the mouse homologue of Rab3c. J Mol Endocrinology 27:117-122, (2001)

27. Zheng MH, Xu J, Robbins P, Pavlos NJ, Wysocki S, Kumta SM, Wood DJ, Papadimitriou JM. Gene expression of vascular endothelial growth factor in giant cell tumours of bone. Hum Pathol 31:804-812 (2000)

ii)Invited Reviews (Peer Reviewed)
1. Pavlos NJ, Jahn R. Distinct yet overlapping roles of Rab GTPases on synaptic vesicles. Small GTPases 2(2): 77-84 (2011)

2. Xu J, Cheng T, Feng HT, Pavlos NJ, Zheng MH. Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis. Histo. Histopathol. 22(4):443-54 (2007)

4. Millar A, Pavlos NJ, Xu J, Zheng MH Rab3D: a regulator of exocytosis in non- neuronal cells. Histo Histpathol, 17:929-36 (2002).
Roles, responsibilities and expertise
Dr Pavlos is Treasurer-elect for the Australian & and New Zealand Society for Orthopaedic Research and a member of the Program Organising Committee for The Australian & New Zealand Bone and Mineral Society. He is also an active reviewer for the National Health & Medical Research Council (NHMRC)and reviewer for several scientific journals
Funding received
NHMRC-Project Grants
NHMRC-CJ Martin (Overseas) Training Fellowship
NHMRC-Equipment Grant
Department of Health WA-NIRISA
Ramaciotti Establishment Grant-Perpetual Funding
Raine Foundation
The CASS Foundation
Sir Charles Gairder Group-Research Grants
UWA Research Grants Scheme
Memberships
Australian & New Zealand Orthopaedic Research Society (ANZORS)
Australian & New Zealand Bone and Mineral Society (ANZBMS)
American Society for Cell Biology (ASCB)
American Society for Bone and Mineral Research (ASBMR)
Honours and awards
2011-New Independent Researcher Infrastructure Support Award (NIRIS) Award
2011-Sir Charles Gairdner Group Research Foundation Best Poster Award
2011-The CASS (Contributing to Australian Scholarship and Science) Foundation Travel Award
2010-Australian and New Zealand Bone and Mineral Society (ANZBMS)Travel Award
2007-American Society for Bone and Mineral Research (ASBMR) Travel Award- For Oral Presentation
2007-International Chinese Hard Tissue Society Young Investigator Prize- For best publication
2006-Raine Research Prize- For best publication
2006-Sol Posen Research Award (ANZBMS)- For best publication in the field of bone and mineral research
2006-University of Western Australia Graduate Research School Publication Prize in Biological Sciences
2002-Christopher & Margie Nordin Young Investigator Award (ANZBMS)- For best poster
2002-Australian and New Zealand Orthopaedic Research Society (ANZORS) Student Presentation Award
2001-Australian and New Zealand Orthopaedic Research Society (ANZORS) Travel Award.
2001-Australian and New Zealand Society for Cell and Developmental Biology Incorporated (ANZSCDBI) Prize-For best poster
2000-Roger Merlick Young Investigator Award (ANZBMS)- For best oral presentation
2000-Australian and New Zealand Bone and Mineral Society Travel Award
1999-Pfizer Prize, For best oral presentation
Previous positions
2007-2009 NHMRC CJ Martin Fellow- Max-Planck-Institute for Biophysical Chemistry, Goettingen, Germany
Teaching
PATH3311 Biotherapeutics and Regenerative Medicine (Unit Co-ordinator)
PATH3302 Pathology: Human Oncobiology
PATH2201 Introduction to Human Disease (Past)

Supervision: Principal and co-supervisor of successfully completed Honours, Masters and PhD students.
New and noteworthy
Invited Speaker-"Resorptive Machinery of Bone-resorbing Osteoclasts", Australian Health and Medical Research Congress (AHMRC), Melbourne, VIC (2010)

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Research profile
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