The University of Western Australia

UWA Staff Profile

Ipsum Lorem

Nicole Smith

Dr Nicole Smith

Research Associate
Molecular Sciences, School of

Contact details
School of Molecular Sciences
The University of Western Australia (M313)
35 Stirling Highway
PhD W.Aust.
NHMRC Research Fellow
Honorary NRP Research Fellow

B.Science (Chemistry & Biochemistry), The University of Sydney, NSW, Australia

PhD (Chemistry), The University of Western Australia (2010), WA, Australia

Postdoc, The Australian National University (2011-2012), Canberra, ACT, Australia

Agence Nationale de la Recherché Postdoctoral Fellow, Institut Européen de Chimie et Biologie (2010-2011), Bordeaux, France
Key research
> Unusual nucleic acid structures in Breast Cancer and Fibrosis
> Targeting G-quadruplex DNA as a novel therapeutic strategy for Alzheimer’s and Frontotemporal Dementia
>Novel mechanism-based enzyme inhibitors for the treatment of Neurotrauma
33. A. Munshi, M. Shi, S. P. Thomas, M. Saunders, M. A. Spackman, K. S. Iyer, N. M. Smith. Magnetically recoverable Fe3O4@Au-coated nanoscale catalysts for the A3-coupling reaction. Dalton Trans., 2017, 46, 5133

32. Nurul Izzy Taib, Vipul Agarwal, Nicole M. Smith, Robert C. Woodward, Timothy G. St. Pierre and K. Swaminathan Iyer. Direct correlation of PNIPAM thermal transition and magnetic resonance relaxation of iron oxide nanoparticles. Mater. Chem. Front., 2017, doi:10.1039/C7QM00202E

31. Naidu PSR, Norret M, Smith NM, Dunlop SA, Taylor NL, Fitzgerald M, Iyer KS. Preferential Enrichment of a range of Proteins Distinguishes the Corona of PEGylated poly(glycidyl methacrylate) Nanoparticles. Langmuir, 2017, doi:10.1021/acs.langmuir.7b02568

30. Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey, and Melinda Fitzgerald. Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma. BMC Neurosci. 2017; 18: 62.

29. R. Singh, D. Ho, L. Y. Lim, K. S. Iyer, N. M. Smith. A colloidal polymeric platform for facile click-assisted ligand functionalization and receptor targeting. ACS Omega, 2016, 1, 1114.

28. C. W. Evans, K. S. Iyer, N. M. SMITH Electrostatic Self-assembly of Nanoparticles Comprehensive Supramolecular Chemistry II, Vol 9, 2016, Elsevier.

27. R. L. O'Hare Doig, C. A. Bartlett, N. M. Smith, S. L. Hodgetts, S. A. Dunlop, L. Hool, M. Fitzgerald. Specific combinations of Ca2+ channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro. Neuroscience, 2016, 339, 450.

26. B. Li, T. D. Clemons, V. Agarwal, J. Kretzmann, M. Bradshaw, P. Toshniwal, N. M. SMITH, S. Li, M. Fear, F. M. Wood, K. S. Iyer. Regulation of collagen expression using nanoparticle mediated inhibition of TGF-b activation. New J. Chem., 2016, 40, 1091-1095.

25. T. D. Clemons, M. Challenor, M. Fitzgerald, S. A. Dunlop, N. M. Smith and K. Swaminathan Iyer. Manipulating Cellular Interactions of Poly(glycidyl methacrylate) Nanoparticles Using Mixed Polymer Brushes. ACS Macro Lett., 2016, accepted; 10.1021/acsmacrolett.6b00613

24. I. Lozic; R. Hartz; C. Bartlett; J. Shaw; M. Archer; P. Naidu; N. M. SMITH; S. Dunlop; S. Iyer; M. Kilburn; M. Fitzgerald. Characterisation of Polymeric Nanoparticles for Treatment of Partial Injury to the Central Nervous System. Data in Brief, 2016, 7, 152-156.

23. Alaa M. Munshi, Vipul Agarwal, Dominic Ho, Colin L. Raston, Martin Saunders, Nicole M. Smith, and K. Swaminathan Iyer. Magnetically Directed Assembly of Nanocrystals for Catalytic Control of a Three-Component Coupling Reaction (2016) Cryst. Growth Des., DOI: 10.1021/acs.cgd.6b00582

22. N M. Smith, D Ho, A Munshi, M. J. House, S. A. Dunlop, M. Fitzgerald, and K. S. Iyer. Poly(glycidyl methacrylate) Coated Dual Mode Upconverting Nanoparticles For Neuronal Cell Imaging (2016) New Journal of Chemistry, 40, 6692

21. N. M. Smith, I. Gachulincova, D. Ho, C. Bailey, C. A. Bartlett, M. Norret, J. Murphy, A. Buckley, P. J. Rigby, M. J. House, T. St. Pierre, M. Fitzgerald, K. S. Iyer and S. A. Dunlop An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles Scientific Reports (2016), 4;6:22595. doi: 10.1038/srep22595.

20. V Agarwal, D Ho, D Ho, Y Galabura, F. M. D. Yasin, P Gong, W Ye, R Singh, A Munshi, M Saunders, R. C. Woodward, T St. Pierre, F. M. Wood, M. Fear, D. Lorenser, D. D. Sampson, B. Zdyrko, I. Luzinov, N. M. Smith and K. S. Iyer A Functional Reactive Polymer Electrospun Matrix ACS Applied Materials and Interface (2016), 8, 4934-4939

19 R. Singh, M. Norret, M. J. House, Y. Galabura, M. Bradshaw, D. Ho, R. C. Woodward, T. St. Pierre, I. Luzinov, N. M. Smith, L. Y. Lim, K. S.
Iyer Dose Dependent Therapeutic Distinction between Active and Passive Targeting Revealed Using Transferrin Coated PGMA Nanoparticles Small (2016), 12, 351-9

18 Vipul Agarwal, Priyanka Toshniwal, Natalie E. Smith, Nicole M. Smith, Binbin Li, Tristan D. Clemons, Lindsay T. Byrne, Foteini Kakulas, Fiona M. Wood, Mark Fear, Ben Corry and K. Swaminathan Iyer, "Enhancing the Efficacy of Cation-Independent Mannose 6- Phosphate Receptor Inhibitors by Intracellular Delivery" Chem. Comm., 2015, DOI: 10.1039/C5CC06826F

17 I Lozić, RV Hartz, CA Bartlett, JA Shaw, M Archer, PSR Naidu, NM Smith, SA Dunlop, K Swaminathan Iyer, MR Kilburn, M Fitzgerald, "Enabling Dual Cellular Destinations of Polymeric Nanoparticles for Treatment Following Partial Injury to the Central Nervous System" Biomaterials, 2015, doi: 10.1016/j.biomaterials.2015.10.001

16. Ka-Heng Loh, Nicole M. Smith, Hideki Onagi, Stephen F. Lincoln, Christopher J. Easton, "A Cyclodextrin-Based Photoresponsive Molecular Gate that Functions Independently of Either Solvent or Potentially Competitive Guests” Chem. Asian J., 2015, DOI: 10.1002/asia.201500696.

15. N. K. Tangudu, V. K. Verma, T. D. Clemons, S. S. Beevi, T. Hay, G. Mahidhara, M. Raja, R. Nair, L. Alexander, A. Patel, J. Jose, N. M. Smith, B. Zdyrko, A. Bourdoncle, I. Luzinov, S. Iyer, A. R. Clarke, L. D. Kumar, "RNA Interference using c-Myc-Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models” Mol Cancer Ther., 2015, DOI: 10.1158/1535- 7163.MCT-14-0970.

14. Ho, Dominic; Zou, Jianli; Chen, Xianjue; Munshi, Alaa; Smith, Nicole M.; Agarwal, Vipul; Hodgetts, Stuart; Plant, Giles; Bakker, Anthony; Harvey, Alan; Luzinov, Igor; Iyer, K, “Hierarchical patterning of multifunctional conducting polymer nanoparticles as a bionic platform for topographic contact guidance” ACS Nano., 2015, 9(2), 1767-1774.

13. Naviin Hardy, Helena Viola, Vicky PA Johnstone, Tristan D Clemons, Henrietta Cserne Szappanos, Ruhani Singh, Nicole M Smith, K Swaminathan Iyer, Livia C Hool, "Nanoparticle-Mediated Dual Delivery of an Antioxidant and a Peptide against the L-type Ca2+ Channel Enables Reduction of Cardiac Ischemia-Reperfusion Injury" ACS Nano., 2015, 9(1), 279-289.

12. Gully, B.S., Shah, K.R., Lee, M., Shearston, K., Smith, N.M., Sadowska, A., Blythe, A.J., Bernath-Levin, K., Stanley, W.A., Small, I.D. “The design and structural characterization of a synthetic pentatricopeptide repeat protein” Acta Cryst. Sect. D., 2015, 71, 196-208.

11. Xianjue Chen, Nicole M. Smith, K. Swaminathan Iyer, Colin L. Raston, "Controlling nanomaterial synthesis, chemical reactions and self assembly in dynamic thin films" Chem. Soc. Rev., 2014,43, 1387-1399.

10. Nicole M. Smith, K. Swaminathan Iyer, Ben Corry, "The Confined Space Inside Carbon Nanotubes can Dictate the Stereo- and Regioselectivity of Diels-Alder reactions" Phys. Chem. Chem. Phys., 2014, 16(15), 6986-6989.

9. Jeremiah Toster, Qin Lin Zhou, Nicole M. Smith, K. Swaminathan Iyer, Federico Rosei, Colin L. Raston, "In situ coating of diatom frustules with silver nanoparticles" Green Chem., 2013, 15, 2060-2063.

8. Donna Savigni, Ryan L O'Hare Doig, Charis R Szymanski, Carole A Bartlett, Ivan Lozic, Nicole Smith, Melinda Fitzgerald, "Three Ca2+ channel inhibitors in combination reduce chronic secondary degeneration following neurotrauma" Neuropharmacology, 2013, 75C, 380-390

7. Nicole M. Smith, Samir Amrane, Frédéric Rosu, Valérie Gabelica, Jean-Louis Mergny, "Mercury-Thymine interaction with a chair type G-quadruplex architecture" Chem. Commun., 2012, 48, 11464-11466.

6. Ben Corry and Nicole M. Smith, "The role of thermodynamics and kinetics in ligand binding to G-quadruplex DNA" Chem. Commun., 2012, vol. 48, pp. 8958-8960.

5. N M Smith, Gaëlle Labrunie, Ben Corry, Phong Lan Thao Tran, Marck Norret, Mojgan Djavaheri-Mergny, Colin L Raston, Jean-Louis Mergny, "Unraveling the relationship between structure and stabilization of triarylpyridines as G-quadruplex binding ligands" Org Biomol Chem., 2011, vol. 9, pp. 6154-6162.

4. Loic Stefan, Aurore Guédin, Samir Amrane, Nicole Smith, Franck Denat, Jean-Louis Mergny, David Monchaud, "DOTASQ as a prototype of nature-inspired G-quadruplex ligand" Chem. Commun., 2011, 47, 4992-4994.

3. N M Smith, B Corry, K Swaminathan Iyer, M Norret, C L Raston, "A microfluidic platform to synthesise a G-quadruplex binding ligand" Lab Chip, 2009, 9, 2021-2025.

2. Nicole Maria Smith, Pengkai Soh, Nithiananthan Asokananthan, Marck Norret, Geoffrey A. Stewart, Colin Llewellyn Raston, "Immunomodulatory effects of functionalised chalcones on pro-inflammatory cytokine release from lung epithelial cells" New J. Chem.,2009, 33, 1793-1980.

1. Nicole M. Smith, Colin L. Raston, Christopher B. Smith, Alexandre N. Sobolev, "PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines" Green Chem., 2007, 9, 1185 - 1190.
Roles, responsibilities and expertise
PhD Students

Pari Tackle - Co-supervised with Ryan Lister and Swaminatha Iyer

Ruhani Singh (Completed) - Co-supervised with Swaminatha Iyer and Lee Yong Lim

Masters Students

2017-2018 - Sara Tai - co-supervised with Swaminatha Iyer

Honours Students

2017-2018 Amy Kretzmann, co-supervised with Archa Fox, Iyer Swaminatha

2017-2018 Chloe Gray, co-supervised with Melinda Fitzgerald

2017-2018 Nikolas Gavriel, co-supervised with Melinda Fitzgerald

2016-2017 Michelle Nguyen, co-supervised with Sarah Dunlop and Lindy Fitzgerald - Awarded 1st Class Honours

Exchange students

2017-2018 Abigail Egid - 3rd Year B.Sc (Hons) student from the University of Bath, UK.

2017-2018 Melanie Grigg - 3rd Year B.Sc (Hons) student from the University of Bath, UK.

2015-2016 Daniella Zimmerman - 3rd Year B.Sc (Hons) student from the University of Bath, UK. Co-supervised with Sarah Dunlop.

2014-2015 Charlotte Bailey– 3rd Year B.Sc (Hons) student from the University of Bath, UK. Co-supervised with Sarah Dunlop.

2013-2014 Ivana Gachulincová – 3rd Year B.Sc (Hons) student from the University of Bath, UK, (Won 1st place in the Bath Student Exchange Program). Co-supervised with Sarah Dunlop.

2013-2014 Andressa Finkler Staudt - pharmacy student from the Universidad Federal do Rio Grande do Sul, (Won 1st Place in the Science Without Borders Program for her final research presentation). Co-supervised with Sarah Dunlop

Undergraduate students:

2015 Saiuj Bhat - Perkins Vacation Scholarship from the Harry Perkins Institute of Medical Research. Co-supervised with Pilar Blancafort and Ryan Lister.

CHEM1004 - Biological Chemistry
MSCI4098/MSCI4099 - Seminar Appraisal and Presentation


Faculty of Science Consumer and Community Engagement Committee

School of Molecular Sciences Consumer and Community Engagement Committee

Funding received
2017 NHMRC Boosting Dementia Research Leadership Fellowship

2017 Neurotrauma Research Program Fellowship

2017 National Breast Cancer Foundation Innovator Grant CI: Smith, Lister, Clark, AI: Hurley, Redfern, Saunders

2017 Australian Synchrotron Beamtime. CIs: Hackett, Smith, Fitzgerald

2017 Cancer Council WA, Collaborative Cancer Grant Scheme CI: Smith, Evans, Tang, Sorolla, AI: Lister, Hurley

2017 UWA Research Collaboration Award – “Developing a 3D mimic of the brain” – CIs: Iyer, Fitzgerald, Choi, Smith, Evans, Thordarson, Martin, Franz, Davies

2016 Neurotrauma Research Program, CI: Smith, AI: Hurley, Fitzgerald and Dunlop - Targeting four-stranded DNA conformations to enable axonal regeneration following neurotrauma

2015 National Health and Medical Research Council, CIs: Fitzgerald, Dunlop, Iyer, Smith - Targeted nanoparticles to deliver novel combinatorial treatments for secondary degeneration following neurotrauma

2015 Neurotrauma Research Program, CI: Smith AI: Dunlop, Iyer, House, Feindel - Using nanotechnology to prevent localised, as well as remote, inflammation and breakdown of the blood brain barrier following neurotrauma

2015 The Raine Medical Research Foundation Healy Research Collaboration award, CI: Smith PI: Hurley (University of Arizona, Tetragene Ltd (Salt Lake City) - Targeting epigenetic markers to modulate G-quadruplex DNA topology as a novel therapeutic strategy for cancer

2014 Neurotrauma Research Program, CI: Smith AI: Dunlop, Iyer, House - Crossing the Blood Brain Barrier: Towards intravenous delivery of theranostic nanoparticles for targeted therapy following neurotrauma
Honours and awards
2017 - NHMRC Boosting Dementia Research Leadership Fellowship
2017 - Neurotrauma Research Program Fellowship
2015 - Finalist Woodside Early Career Scientist of the Year, WA Premier's Science Awards
2015 - The Raine Medical Research Foundation Healy Research Collaboration award
2010-2011 Agence Nationale de la Recherche postdoctoral research fellowship
2010 - Best research presentation award - XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids Conference
2008 - UWA Travel Scholarship
CHEM1004 - Biological Chemistry
MSCI4098/MSCI4099 - Seminar Appraisal and Presentation
Research profile
Research profile and publications

The University of Western Australia

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Last updated:
Tuesday, 3 November, 2015 2:39 PM