The University of Western Australia

UWA Staff Profile

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Stuart Hodgetts

Dr Stuart Hodgetts

Senior Lecturer/Senior Research Fellow
Anatomy, Physiology and Human Biology, School of

Contact details
Address
School of Anatomy, Physiology and Human Biology
The University of Western Australia (M309)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 6488 8642
Fax
+61 8 6488 1051
Email
stuart.hodgetts@uwa.edu.au

Scientific Coordinator
SymbioticA, The Centre of Excellence in Biological Arts

Contact details
Address
SymbioticA, The Centre of Excellence in Biological Arts
The University of Western Australia (M309)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 6488 8642
Email
stuart.hodgetts@uwa.edu.au

Director
Spinal Cord Repair Laboratory, The

Contact details
Address
The Spinal Cord Repair Laboratory
The University of Western Australia (M309)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Phone
+61 8 6488 8642
Email
stuart.hodgetts@uwa.edu.au
Qualifications
BSc PhD Essex
Biography
Dr. Stuart Hodgetts has extensive knowledge and expertise in cell based transplantation therapies and has been devoted to this area of research since 1998. Previous postdoctoral work includes, 2.5yrs at the Oklahoma Medical Research Foundation, USA (immunological gene transcription), 7yrs in the Muscle Research Team at the School of Anatomy & Human Biology, (ANHB) at UWA (myoblast transfer therapy for Duchenne muscular dystrophy). In 2003, through collaboration with Giles Plant, SH has changed fields to apply his expertise to spinal cord repair using adult mesenchymal human bone marrow stromal stem cells.
Key research
Spinal Cord Repair
Bone Marrow Stromal Cells
Immunotherapy
Tissue Engineering
Publications
1) Buchanan, K.L., Hodgetts, S.I., Byrnes, J. and Webb, C.F. (1995). “Differential Transcription Efficiency of Two Ig VH Promoters In Vitro.” Journal of Immunology 155: 4270-4277. Impact Factor=6.068
2) Hodgetts, S.I., Buchanan, K.L., Byrnes, J. and Webb, C.F. (1995). “Differential Interaction of Nuclear Matrix Proteins with Regulatory Sequences Upstream of Immunoglobulin Heavy Chain Promoters.” Journal of Cellular Biochemistry Supplement 19D. Impact Factor=3.381
3) Lancaster, M.U., Hodgetts, S.I., Mackenzie, J.S. and Urosevic, N. (1997). “Characterisation of Viral Defective RNA Produced During Persistent Infection of Vero Cells with Murray Valley Encephalitis Virus.” Journal of Virology 72(3): 2474-82. Impact Factor=5.332
4) Hodgetts, S.I., Davies, M., Smythe, G.M., Fan, Y., Beilharz, M.W. and Grounds, M.D. (1998). "Quantitation of Donor Male Myoblast Survival in Cell Transplantation Experiments in Dystrophic Mice." Muscle & Nerve Supp. 7 S126 Impact Factor=2.458
5) Urosevic, N., Silvia, O., Sangster, M.Y., Mansfield, J.P., Hodgetts, S.I., Shellam, G.R. (1999). "Development and Characterisation of New Flavivirus-resistant Mouse Strains Bearing Flvr-like and Flvmr Alleles from Wild or Wild-derived Animals." Journal of General Virology 80: 897-906. Impact Factor= 3.12
6) Hodgetts,S.I. and Grounds, M.D. (1999). "Isolation of Mouse Skeletal Muscle Myoblasts with Blendzyme 3". Roche Molecular Biochemicals Website http://www.collagenase.com/prodinfo_fst.htm?/
7) Hodgetts, S.I., Beilharz, M.W., Scalzo, A.A. and Grounds, M.D. (2000). "Why Do Cultured Transplanted Myoblasts Die In Vitro? DNA Quantification Shows Enhanced Survival of Donor Male Myoblasts in Host Mice Depleted of CD4+ and CD8+ or NK1.1+ Cells." Cell Transplantation 9(4): 489-502. Impact Factor=3.871
8) Smythe GM, Hodgetts SI, Grounds MD. (2000). "Immunobiology and the Future of Myoblast Transfer Therapy". Molecular Therapy. 1(4): 304 -313. [see http:www.apnet.com/moltherapy]. Impact Factor=5.862
9) Stuart I Hodgetts and Miranda D Grounds. (2001) "Complement and myoblast transfer therapy: Donor myoblast survival is enhanced following depletion of host complement C3 using cobra venom factor, but not in the absence of C5". Immunology and Cell Biology 79 (3): 231-239. Impact Factor=3.03
10) Smythe GM, Hodgetts SI, Grounds MD. (2001). INVITED REVIEW: "Problems and Solutions in Myoblast Transfer Therapy". Journal of Cellular and Molecular Medicine 5(1): 33-47. Impact Factor=6.8
11) Stuart I. Hodgetts, and Miranda D. Grounds. (2001). "Natural Killer Cells and the Death of Donor Myoblasts in Myoblast Transfer Therapy." Cell Transplantation 10 (6) p512. Impact Factor= 3.871
12) Sammels, L., C. Fragall, C., Hodgetts, S.I., Grounds, M.D. and Beilharz, M. (2002). "Myoblast transfer therapy (MTT): CFSE Labelling of Donor Myoblasts to Track Their Fate in Recipient Mdx Mice". Journal of Neurological Sciences 199, Supp 1 P-043
13) Hodgetts,S.I. Spencer, M. and Grounds, M.D. (2003) "A Role for Natural Killer Cells in the Rapid Death of Cultured Donor Myoblasts After Transplantation " Transplantation 75: p863-871. Impact Factor= 3.64
14) Hodgetts,S.I. and Grounds, M.D. (2003). "Irradiation of dystrophic host tissue prior to Myoblast Transfer Therapy enhances initial (but not long-term) survival of donor myoblasts." Journal of Cell Science 116: p4131-4146. Impact Factor=6.383
15) Bosio, E. Pullen, T.F., Fragall, C.T. Beilharz, M.W., Bennett, A.L., Grounds, M.D. Hodgetts, S.I., and Sammels, L. (2004). “A comparison between real-time quantitative PCR and DNA hybridisation for quantitation of male DNA following myoblast transplantation”. Cell Transplantation. 13(7-8):817-821. Impact Factor=3.871
16) Miranda D. Grounds, Marilyn Davies, Jo Torrisi, Jason White, Stuart Hodgetts (2005). "Silencing TNF activity using Remicade® or Enbrel® blocks inflammation in whole muscle grafts: an in vivo bioassay to assess the efficacy of anti-cytokine drugs in mice." Cell and Tissue Research 320 (3):509-15. Impact Factor= 2.62
17) Hodgetts, S., Radley H, Davies M, Grounds MD (2006). "Reduced necrosis of dystrophic muscle by depletion of host neutrophils, or blocking TNFalpha function with Etanercept in mdx mice." Neuromuscular Disorders 16:p591-602.
Impact Factor=2.667
18) Cui, Q*., Hodgetts, SI*, Y. Hu, J-M Luo, Harvey, A. (2007). "Strain Specific Differences in the effects of Cyclosporin A and FK506 on the survival and regeneration of axotimised retinal ganglion cells in adult rats." (Neuroscience 146: 986-999). Note: * - Co-1st Author Impact Factor=3.4
Roles, responsibilities and expertise
SH is also Director of Tissue Culture Facilities at ANHB (UWA), Treasurer UWA Research Staff Association, Executive Committee Member (ANHB), Assistant Health & Safety Officer (ANHB), Focus Group member for research restructure, (ANHB), and Founding committee member of the Biology Society, Essex University, UK.
Funding received
SH has been CI on grants totalling $1,424,781 since 2001-2007. He currently is funded by the Victorian Neurotrauma Initiative and the Neurotrauma Research Program (NRP) of WA.
Teaching
•Assistant lecturer and demonstrator for 325 Neurobiology undergraduates at the School of Anatomy and Human Biology, University of Western Australia, Nedlands, Western Australia (2006-2008)
•Tissue Engineering Workshop (Collaboration with Oron Catts & Ionat Zurr – Symbiotica) AV06 Festival, United Kingdom, 2006
•325 Neuroscience (for final year Human Biology undergraduates at the School of Anatomy and Human Biology, University of Western Australia, Nedlands, Western Australia) (2005-present)
•Lecturer and demonstrator in 313 Molecular Biology (DNA/RNA isolation and purification, Southern and Northern blotting, RFLP analysis, plasmid construction, PCR and sequencing) and 313 Tissue Culture (primary and established cell line culture, monoclonal antibody production) for final year Human Biology undergraduates at the School of Anatomy and Human Biology, University of Western Australia, Nedlands, Western Australia (1998-present). SPOT tested.
•Lecturer and demonstrator in 308 Developmental Biology for final year undergraduates at the School of Anatomy and Human Biology, University of Western Australia, Nedlands, Western Australia (Jan 2003 and 2004).
•Lecturer and demonstrator in Developmental Biology and Reproduction. Biological Sciences final year undergraduates and Nursing students at Essex University, U.K. (1993).
•Special tutor/examiner for overseas student for the University Overseas Department in Biology (Oct 1991-March 1992).
•Assistant lecturer. Immunology Conference, British Society of Immunology, University of Essex, U.K. (1990).
Current projects
Human Bone Marrow Stromal Cells in spinal cord repair
Research profile
Research profile and publications
 

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Last updated:
Tuesday, 3 November, 2015 2:39 PM