The University of Western Australia

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Wayne Davies

Dr Wayne Davies

Future Fellow
Animal Biology, School of

Contact details
Address
School of Animal Biology
The University of Western Australia (M092)
35 Stirling Highway
CRAWLEY WA 6009
Australia
Email
wayne.davies@uwa.edu.au
Personal homepage
http://www.scoreexchange.com/profiles/wayneldavies
Biography
Wayne I. L. Davies received his PhD from Cambridge University, UK. Professionally linked to many internationally renowned research institutions, Wayne Davies is currently an Australian Research Council Future Fellow and an Associate Professor at the School of Animal Sciences, University of Western Australia, Australia. His main research interests broadly encompass the molecular evolution and functional characterisation of gene families, and the mechanisms that regulate gene expression. Specifically, A/Prof. Davies investigates the evolutionary origins, molecular ecology, function and spectral tuning of photopigments that mediate chordate visual and non-visual light detection, and their phototransduction cascades. His work also extends to determining genetic mutations in retinal and neurological diseases. Other interests include tissue-specific regulation of ABC transporters, in particular the cystic fibrosis (CFTR) gene, novel mechanisms of gene regulation (e.g. post-transcriptional regulation and non-coding RNA networks of gene expression), and the phylogenetic relationships that exist between and across large protein superfamilies (e.g. GPCRs, ABC transporters, ion channels).
Key research
Molecular evolution of image-formation, colour vision and phototransduction.
Functional genomics of non-visual sensory systems.
Circadian photobiology.
Retinal disease and circadian dysfunction.
Gene evolution, expression and regulatory mechanisms (e.g. post-transcriptional regulation and non-coding RNA networks).
Next-generation sequencing and transcriptomes (RNA-Seq).
ABC transporters and ion channels (e.g. cystic fibrosis and the CFTR gene).
Structure/function of GPCRs and optogenetics.
Publications
42 peer-reviewed published articles (top 12 are listed below):

Davies, W.I. (2014) Challenges using diagnostic next-generation sequencing in the clinical environment for inherited retinal disorders. Personalized Medicine 11: 99–111.

Davies, W.I., Tay, B.H., Zheng, L., Danks, J.A., Brenner, S., Foster, R.G., Collin, S.P., Hankins, M.W., Venkatesh, B. & Hunt, D.M. (2012) Evolution and Functional Characterisation of Melanopsins in a Deep-Sea Chimaera (Elephant Shark, Callorhinchus milii). PLOS ONE 7: e51276.

Davies, W.I., Downes, S.M., Fu, J.K., Shanks, M.E., Copley, R.R., Lise, S., Ramsden, S.C., Black, G.C., Gibson, K., Foster, R.G., Hankins, M.W. & Németh, A.H. (2012) Next-generation sequencing in health-care delivery: lessons from the functional analysis of rhodopsin. Genetics in Medicine 14: 891-899.

Davies, W.I., Collin, S.P. & Hunt, D.M. (2012) Molecular ecology and adaptation of visual photopigments in craniates. Molecular Ecology 21: 3121-3158.

Davies, W.I., Zheng, L., Hughes, S., Tamai, T.K., Turton, M., Halford, S., Foster, R.G., Whitmore, D. & Hankins, M.W. (2011) Functional diversity of melanopsins and their global expression in the teleost retina. Cellular and Molecular Life Sciences 68: 4115-4132.

Halford, S., Pires, S.S., Turton, M., Zheng, L., González-Menéndez, I., Davies, W.L., Peirson, S.N., García-Fernández, J.M., Hankins, M.W. & Foster, R.G. (2009) VA opsin-based photoreceptors in the hypothalamus of birds. Current Biology 19: 1396-1402.

Davies, W.L., Cowing, J.A., Bowmaker, J.K., Carvalho, L.S., Gower, D.J. & Hunt, D.M. (2009) Shedding light on serpent sight: the visual pigments of henophidian snakes. Journal of Neuroscience 29: 7519-7125.

Davies, W.L., Collin, S.P. & Hunt, D.M. (2009) Adaptive gene loss reflects differences in the visual ecology of basal vertebrates. Molecular Biology and Evolution 26: 1803-1809.

Davies, W.L., Carvalho, L.S., Tay, B.H., Brenner, S., Hunt, D.M. & Venkatesh, B. (2009) Into the blue: gene duplication and loss underlie colour vision adaptations in a deep-sea chimaera, the elephant shark Callorhinchus milii. Genome Research 19: 415-426.

Davies, W.L., Carvalho, L.S., Cowing, J.A., Beazley, L.D., Hunt, D.M. & Arrese, C.A. (2007) Visual pigments of the platypus: a novel route to mammalian colour vision. Current Biology 17: R161-R163.

Davies, W.L., Vandenberg, J.I., Sayeed, R.A. & Trezise, A.E. (2004) Cardiac expression of the cystic fibrosis transmembrane conductance regulator involves novel exon 1 usage to produce a unique amino-terminal protein. Journal of Biological Chemistry 279: 15877-15887.

Collin, S.P., Knight, M.A., Davies, W.L., Potter, I.C., Hunt, D.M. & Trezise, A.E. (2003) Ancient colour vision: multiple opsin genes in the ancestral vertebrates. Current Biology 13: R864-865.
Roles, responsibilities and expertise
Australian Research Council (ARC) Future Fellow.

Associate Editor for Frontiers in Ecology and Evolution: Frontiers in Behavioral and Evolutionary Ecology.

Academic Editor for PLOS ONE.

Editorial Board Member for the Journal of Clinical Research and Ophthalmology.

Editorial Board Member for the HSOA Journal of Ophthalmology and Clinical Research.

Editorial Board Member for Dataset Papers in Science: Genetics.
Funding received
Australian Research Council (ARC) Future Fellowship (2011-2016): "Investigating the molecular mechanisms underlying non-visual photoreception and their implications in the
treatment of human neurological disease."

ARC Discovery Project Grant (2014-2017) [Lead CI]: "Transcriptome Sequencing & Functional Characterisation of Craniate Non Visual Sensory Systems & their Adaptation to Diverse Light Environments."

ARC Linkage Infrastructure, Equipment and Facilities (LIEF) Grant (2014) [co-CI]: "Western Australian Zebrafish Facility."
Languages
English.
Honours and awards
Australian Research Council (ARC) Future Fellowship.
Previous positions
Senior Research Associate: University of Oxford (2008-2012).

Senior Research Associate: University College London (2005-2008).

Senior Post-doctoral Research Scientist: University of Cambridge (2005).

Post-doctoral Research Scientist: University of Queensland (2002-2004).
Teaching
Honours and PhD teaching.
Current projects
Molecular evolution of image-formation, colour vision and phototransduction.

Functional genomics of non-visual sensory systems.

Circadian photobiology.

Retinal disease and circadian dysfunction.

Gene evolution, expression and regulatory mechanisms (e.g. post-transcriptional regulation and non-coding RNA networks).

Next-generation sequencing and transcriptomes (RNA-Seq).

ABC transporters and ion channels (e.g. cystic fibrosis and the CFTR gene).

Structure/function of GPCRs and optogenetics.
 

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Last updated:
Tuesday, 3 November, 2015 2:39 PM