The University of Western Australia

UWA Staff Profile

Ipsum Lorem

Dr Andrea Holme

Senior Lecturer (Cytometry, CMCA@Perkins)
Microscopy, Characterisation and Analysis, Centre for (CMCA)

Contact details
Centre for Microscopy, Characterisation and Analysis (CMCA)
The University of Western Australia (M519)
35 Stirling Highway
+61 8 6151 1009
Dwyer, A.R., Ellies, L.G., Holme, A.L., Pixley, F.J., 2016, A three-dimensional co-culture system to investigate macrophage-dependent tumor cell invasion, J Biol Methods, 3(3):e49

Lopez-Orozco, J., Pare, J.M., Holme A.L., Chaulk, S.G., Fahlman, R.P., Hobman, T.C., 2015, Functional analyses of phosphorylation events in human Argonaute 2, RNA, 21(12): 2030-8

Mellier G., Liu D., Bellot G., Holme A.L., Pervaiz S., 2013, Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27, Cell Death Dis., 4: e890

Pervaiz, S., Holme, A.L., 2009, Resveratrol: its biologic targets and functional activity,
Antioxid Redox Signal., 11(11):2851-97

Kwajah M.M .S., Mustafa N., Holme A.L., Pervaiz S., Schwarz H.J., 2011, Biphasic activity of CD137 ligand-stimulated monocytes on T cell apoptosis and proliferation, Leukoc Biol., 89(5):707-20

Holme, A.L., Kumar Yadav, S., Pervaiz, S., 2007, Automated Laser Scanning Cytometry: A Powerful Tool For Multi-parameter Analysis of Drug-induced Apoptosis, Cytometry A., 71(2):80-6

Koo., M.K., Oh, C.H, Holme,A.L., Pervaiz, S., 2007, Simultaneous Analysis of Steady-state Intracellular pH and Cell Morphology by Automated Laser Scanning Cytometry, Cytometry A., 71(2):87-93

Holme, A.L., Pervaiz, S., 2007, Resveratrol in cell fate decisions, J Bioenerg. Biomembr., 39(1):59-63

Fry, F.H.*, Holme, A.L.*, Giles. N.M., Giles. G.I., Collins. C., Holt. K., Pariagh. S., Gelbrich. T., Hursthouse. M.B., Gutowski. N.J., Jacob. C., 2005, Multifunctional redox catalysts as selective enhancers of oxidative stress, Org Biomol Chem., 3(14):2579-87, *joint first authors

Collins, C.A., Fry, F.H, Holme, A.L., Yiakouvaki, A., Al-Qenaei, A., Pourz, C., Jacob, C., 2005, Towards multifunctional antioxidants: synthesis, electrochemistry, in vitro and cell culture evaluation of compounds with ligand/catalytic properties, Org Biomol Chem., 3(8):1541-6

Pariagh, S., Tasker, K.M., Fry, F.H., Holme, A.L., Collins, C.A., Okarter, N., Gutowski, N.,
Jacob, C., 2005, Asymmetric organotellurides as potent antioxidants and building blocks of protein conjugates, Org Biomol Chem., 3(6):975-80

Jacob, C., Holme A.L., Fry, F.H., 2004, The sulfinic acid switch in proteins, Org Biomol Chem., 2(14):1953-6

Giles, G.I., Fry, F.H., Tasker, K.M., Holme, A.L., Peers C., Green K.N., Klotz L.O., Sies H., Jacob, C., 2003, Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential, Org Biomol Chem., 1(23):4317-22

Holme, A., Daniels, M., Sassoon, J., Brown, D.R., 2003, A novel method of generating neuronal cell lines from gene-knockout mice to study prion protein membrane orientation, Eur J Neurosci., 18(3):571-9

Cui, T., Holme, A., Sassoon, J., Brown, D.R., 2003, Analysis of doppel protein toxicity,
Mol Cell Neurosci., 23(1):144-55

Book Chapter:

Holme, A.L., Pervaiz, S., 2009, Neurohormetic Properties of the Phytochemical Resveratrol, In Micronutrients and brain health (eds. Lester Packer, Helmut Sies, Manfred Eggersdorfer, Enrique Cadenas, CRC Press Taylor and Francis Group LLC)

Pervaiz, S., Holme, A.L., 2005, Apoptotic activity of resveratrol, In Resveratrol in Health and Disease, (eds. Bharat Aggarwal, Shishir Shishodia, CRC Press Taylor and Francis Group LLC)

Roles, responsibilities and expertise
Academic Senior Lecturer in Cytometry,
Head of Cytometry Core
Funding received
Advancing single-cell analysis and isolation in Western Australia
Prof Ryan Lister; Prof Michael Berndt; Prof Shaun Collin; Prof Alistair Forrest; Dr Elin Gray; Dr Joel GUMMER; Dr Andrea Holme; Dr Garth Maker; Dr Navid Moheimani; Prof Ian Small; Dr Janina Tirnitz-Parker; Prof Mel Ziman, LE170100225 ARC 2017, Awarded: $410,000

Super Sampler for time of flight mass cytometer and Coulter Counter Z, 2 Lead CI: Dr Andrea Holme, NHMRC Equipment Grant 2015, Awarded: $44,502
International Society for Advancement of Cytometry
Member of the ISAC elearning Educational Delivery Task Force
Honours and awards
ISAC Marylou Ingram Scholar (2008-2013)
ISAC Best Published Paper Award (2008)
Method of decontaminating, disinfecting or sterilizing of an article by means of an electrolytic system or by reactive oxygen species Inventor: Jacob Claus; Fry Fiona; Holme Andrea Patent Nr. WO2005039653
CMCA Cytometry Theory Course
CMCA Cytometry one-on-one training
Useful links
CMCA Cytometry:
Research profile
Research profile and publications

The University of Western Australia

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Last updated:
Tuesday, 3 November, 2015 2:39 PM